I-Wisepowder inoluhlu olupheleleyo lwezixhobo zokuguga kunye nokuguga, kwaye inenkqubo epheleleyo yolawulo lomgangatho.

Ibonisa i-1-4 yeziphumo ezingama-13

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Ukwaluphala kunye nokuGuga (Ukuchasana nokuguga)

Ukuguga yinto esiyenzayo sonke kodwa siyiqonda kancinci malunga nayo. Ingqondo yakho ithatha utshintsho njengoko uneminyaka yobudala enokuba neziphumo ezincinci kwimemori yakho okanye kwizakhono zokucinga Kulula ukwenza uluhlu lwazo zonke iinguqu eziza nobudala - ukulahleka kwememori, imibimbi, ukulahleka kwemisipha.
Ukulwa nokwaluphala (anti-ukuguga) kunokuba sisihloko esinzima ukujongana naso: umlo ngoku ulwelwa ngaphezulu kwentsingiselo yegama kuphando kunye nonyango, nanjengemveliso kwiimveliso ngamandla kwaye zihlala zinobuqhophololo.
Ukulwa nokwaluphala (Anti-ukwaluphala) ngoku ineentsingiselo ezininzi ezahlukileyo kunye nezinxulumene.
-Kuluntu lwezenzululwazi lokulwa nokwaluphala (anti anti) uluntu lubhekisa kuphela ekucothiseni, ukunqande, okanye ekubuyiseni kwinkqubo yokwaluphala. Ngelixa ikamva likhangeleka lithembisa kakhulu, okwangoku akukho teknoloji iqinisekisiweyo kwaye ikho ekhoyo ethi icothise okanye ibuyisele abantu ukuguga ebantwini.
-Kwezoluntu kunye noluntu oluneshishini olululo, iyeza lokulwa ukwaluphala lithetha ukufunyanwa kwangoko, ukuthintela kunye nokunyanga izifo ezinxulumene nobudala. Oku kwahluke kakhulu ekujonganeni nenkqubo yokwaluphala uqobo, kwaye uluhlu olubanzi lweendlela kunye nonyango ziyafumaneka ngoku. Umzekelo unyango lwe-Alzheimer, isifo esinxulumene nokwaluphala.
-Kuluntu olubanzi lweshishini- olubandakanya uninzi lwenkohliso okanye amashishini angenamsebenzi - ukulwa nokuguga luphawu oluxabisekileyo kunye nendlela ebonakalisiweyo yokwandisa ukuthengisa.

Ukusetyenziswa komgubo wokuguga

Kule meko, iimveliso ezichasene nokwaluphala ziya ngokuya zithandwa. Isicelo somgubo wokuguga kubandakanya:
Iimveliso zokukhathalela abantwana
Iimveliso zezempilo
-Iziselo ezilandelanayo
Imveliso yeParmaceutical
Ukwaluphala kunye nonyango lwe-Alzheimer
Isifo sengqondo esixhalabisayo siba yinto eqhelekileyo kubudala. Phantse iipesenti ezi-3 zabantu abaphakathi kweminyaka engama-65 nengama-74, iipesenti ezingama-19 phakathi kwama-75 nama-84, kwaye phantse isiqingatha sabo baneminyaka engaphezu kwama-85 ubudala banesifo sengqondo esixhalabisayo. izifo zesifo sika-Alzheimer, isifo se-cerebrovascular, isifo sika-Parkinson kunye nesifo sikaLou Gehrig.
Ukwaluphala yeyona nto iphambili kwisifo sika-Alzheimer. Isifo i-Alzheimer luhlobo lwesifo sengqondo esixhalabisa ingqondo, ukucinga nokuziphatha. Iimpawu ze-Alzheimer zihlala zikhula kancinci kwaye ziya zisanda ngokuhamba kwexesha, ziba nzima ngokwaneleyo ukuba zingaphazamisa imisebenzi yemihla ngemihla. "Siyazi ukuba ubudala yeyona nto inegalelo kakhulu kwi-Alzheimer's, ngoko ke ayimangalisi into yokuba sifumene iziyobisi ekuthiwa ziyaluphala."
I-FDA ikwamkelwe njengeNamzaric, indibaniselwano yaseNamenda (memantine) kunye neAricept, kunyango lokumodareyitha kwesesifo i-Alzheimer's.
INamendais (memantine) ekukholelwa ukuba isebenza ngokulawula ubushushu, ikhemikhali yobuchopho ebalulekileyo. Xa iveliswe kakhulu, glutamate inokukhokelela ekufeni kweseli yobuchopho. Ngenxa yokuba abachasi be-NMDA basebenza ngokwahlukileyo kwi-inhibitors ye-cholineterase, ezi ntlobo zimbini zamachiza zinokumiselwa ngokudibeneyo.
Iimveliso ezininzi ezintsha ziyaziwa ukuba ziluncedo ekunyangeni isifo se-Alzheimer's. Njenge-J-147 powder, CMS121 powder.

Imveliso yokuguga emgubo

J-147 powder (1146963-51-0)I-J147 yinto ye-elixir yanamhlanje yobomi, ibonakalisiwe ukunyanga isifo se-Alzheimer kunye nokuguqula ukuguga kwiimpuku kwaye sele ilungele uvavanyo lwezonyango ebantwini.Iqela sele lenza izifundo ezongezelelweyo kwiimolekyuli eziguqulwe yimpembelelo ye-J147 i-mitochondrial ATP synthase-enokuthi yona ibe ziithagethi zamachiza amatsha. I-J147 igqibile ukuvavanywa kwe-FDA-efunekayo kwi-toxicology kwizilwanyana.
I-Alpha-lipoic acid powder (1077-28-7): I-alpha-lipoic acid yimichiza efana nevithamini ebizwa ngokuba yi-antioxidant, ethetha ukuba inokuthi ikhusele kwingqondo phantsi kweemeko zomonakalo okanye zokonzakala.
I-alpha-lipoic acid ibonakala inceda ukukhusela iintlobo ezithile zomonakalo weseli emzimbeni, kwaye iphinde ibuyisele amanqanaba eevithamini anjengevithamini E kunye nevithamin C. Kukho ubungqina bokuba i-alpha-lipoic acid inokuwuphucula umsebenzi kunye nohambo lwee-neurons kwiswekile.
Ukulahleka kwememori kukukhathazeka okuqhelekileyo phakathi kwabantu abadala.Ukholelwa ukuba umonakalo ovela kuxinzelelo lwe-oxidative udlala indima ebalulekileyo ekulahlekelweni yimemori.
Ngenxa yokuba i-alpha-lipoic acid ine-antioxidant enamandla, uphononongo luvavanye amandla alo okucothisa ukuqhubela phambili kokuphazamiseka okubonakaliswa kukulahleka kwememori, njengesifo se-Alzheimer's.
Igwele, isibindi, izintso, isipinatshi, i-broccoli, kunye neetapile yimithombo elungileyo ye-alpha-lipoic acid.
I-CMS121 powder (1353224-53-9): Ii-Geroprotectors zizinto ezinokubakho ukucothisa inqanaba lesilwanyana xa sijolise kwinkqubo yokuguga. Isifundo esitsha sivavanya inani leekhompawundi kwaye sichonga ezinye ezikhusela ii-neurons kwingozi ngokunciphisa inkqubo yokuguga; Abaphandi bathiye ezi khompawundi ziigeroneuroprotectors.
Ngokusebenzisa ezi komxokelelwane njengesiseko, abaphandi badale abagqatswa beziyobisi abathathu beAlzheimer ebizwa ngokuba yiCMS121, CAD31, neJ147; basebenzise ifisetin kunye ne-curcumin ngqo. Iqela libonise ukuba zonke ezi zinto zihlanganisiweyo zinciphise i-biomarkers yokwaluphala, yonyusa ixesha lokuphila kweempuku kunye neempukane, kwaye yanciphisa iimpawu zesifo sengqondo esixhalabisayo.

Ukuvela kokwaluphala

Ukuguga yimpembelelo yexesha emzimbeni womntu, kwaye kwenzeka ngokwamanqanaba amaninzi:
-Cellular ukuguga. Iiseli ubudala ngokusekelwe kwinani lamaxesha abaziphindileyo. Iseli inokuphindaphinda kangangezihlandlo ezingama-50 ngaphambi kokuba izinto zofuzo zingabi namandla okukhutshelwa ngokuchanekileyo, ngenxa yokunqunyulwa kwetelomeres. Owona monakalo mkhulu owenziwe kwiiseli zii-radicals zasimahla kunye nezinye izinto, iiseli ezininzi kufuneka ziphindaphindwe.
-Ukuguga kweHormonal. AmaHlala adlala indima enkulu ekwaluphaleni, ngakumbi ngexesha lokukhula komntwana kunye nokuqina komntwana. Amanqanaba ama-Horm ayatshintsha kubomi. Ukufikisa kuzisa amabala kunye neepores ezinkulu. Njengoko sisaluphala, iinguqu zehomoni zikhokelela kulusu olomileyo kunye nokuya esikhathini.
Umonakalo ogqityiweyo. Umonakalo odibeneyo ungaphandle onke. Ukubonakaliswa yityhefu, ilanga, ukutya okuyingozi, ungcoliseko kunye nomsi kuthintela umzimba. Ixesha elingaphezulu, ezi zinto zangaphandle zingakhokelela ekonakaleni kwezicubu kwaye umzimba ubuye umva kwisakhono sawo sokugcina nokulungisa iiseli, izicubu namalungu.
-Ukuguga kweMetabolic. Njengoko uqhubeka malunga nomhla wakho, iiseli zakho zihlala ziguqula ukutya kube ngamandla, okuvelisa i-byproducts enokuba yingozi. Inkqubo yokwenza imetabolism kunye nokwakha iziphumo zamandla kumonakalo womzimba ngokuhamba kwexesha. Abanye bakholelwa ukuba ukunciphisa isantya se-metabolic ngenkqubo efana nokuthintela ikhalori kunokucothisa ukuguga ebantwini.
Iimpawu zokuziphatha eziqhelekileyo zeAlzheimer zibandakanya ukungalali, ukuzula, ukuqaqanjelwa, ukuxhalaba, ukulwa, ukungaxhamli kunye nokudakumba. Izazinzulu ziyafunda ukuba kutheni le nto zivela kwaye zifundisa unyango olutsha — iziyobisi kunye nondrug- ukululawula.

Imbekiselo:

  1. Mortimer RK, Johnston JR (1959). "Ubomi bexesha leeseli zomntu ngamnye". Indalo. 183 (4677): 1751-1752. Ikhowudi: 1959Natur.183.1751M. ikhonkco: 10.1038 / 1831751a0. I-hdl: 2027 / mdp.39015078535278. IINKCUKACHA:
  2. Uvavanyo olujolise kwiziyobisi lwesifo i-Alzheimer lubonisa iziphumo ezichasene nokwaluphala ”(Ukhuphelo lweendaba). IZiko leSalk. 12 Novemba 2015. Ibuyiswe ngo-Novemba 13, 2015.
  3. Abaphandi bachonga i-molekyuli ekujolise kuyo ye-J147, ekufutshane nezilingo zonyango ukunyanga isifo se-Alzheimer ”. Ifunyenwe ngo-2018-01-30.
  4. Ukulungelelaniswa kwesifo seAlzheimer Isifo seNeuropathologic kunye neMeko yokuqonda: Uphengululo loncwadi uPeter T. Nelson, u-Irina Alafuzoff, u-Eileen H. Bigio, uConstantin Bouras, uHeiko Braak, uNigel J. Cairns, uRudolph J. Castellani, uBarbara J. Crain, uPeter UDavies, uKelly Del Tredici, uCharles Duyckaerts, uMateyu P. Frosch, uVahram Haroutunian, uPatrick R. Hof, uChristine M. Hulette, uBradley T.Hyman, uTakeshi Iwatsubo, uKurt A. Jellinger, uGregory A. Jicha, uEnikö Kövari, uWalter A UKukull, uJames B. Leverenz, uSeth Love, u-Ian R. Mackenzie, uDavid M. Mann, uEliezer Masliah, u-Ann C. McKee, uThomas J. Montine, uJohn C. Morris, uJulie A. Schneider, uJoshua A. Sonnen, uDietmar R. Thal, John Q. Trojanowski, Juan C. Troncoso, Thomas Wisniewski, Randall L. Woltjer, Thomas G. Ibhantshi J Neuropathol Exp Neurol. Umbhalo obhaliweyo; ifumaneka kwi-PMC 2013 Jan 30. Ipapashwe kwifom yokugqibela ehleliweyo njengo: J Neuropathol Exp Neurol. 2012 Meyi; 71 (5): 362--381. ikhonkco: 10.1097 / NEN.0b013e31825018f7