iimveliso

Urolithin B umgubo (1139-83-9)

I-Urolithin B yimetabolite yendalo ye-ellagitannin ekhoyo kwiirharnati kunye nezinye iziqhamo kunye namandongomane. Yaziwa ngoososayensi njengechiza elichasene nokwaluphala, ukulawulwa ngomlomo kunokubuyisela i-mitochondria kunye nokuguqula ukuguga kwemisipha, kwaye yimetabolite yamathumbu emathumbu.

Ukuvelisa: Imveliso yeBatch
ipakethe1KG / ibhegi, 25KG / igubu
Umgubo wobulumko unamandla okuvelisa nokubonelela ngobuninzi. Yonke imveliso phantsi kwemeko ye-cGMP kunye nenkqubo engqongqo yokulawula umgangatho, onke amaxwebhu okuvavanya kunye nesampuli ekhoyo.

Urolithin B ulwazi lwesiseko somgubo

igama Urolithin B Umgubo
CAS 1139-83-9
Ukungcola 98%
Igama leKhemikhali I-3-Hydroxy-6H-dibenzo [b, d] ipyran-6-inye
Iintetho ezifanayo AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR
I-Molecular Formula C13H8O3
Isisindo somzimba 212.2 g / mol
Indawo yokunyibilika 247 ° C
InChI Key I-WXUQMTRHPNOXBV-UHFFFAOYSA-N
imo solid
Kubonakala Umgubo onsundu omdaka
Ubomi obulicla /
Umzimba i-soluble5mg / mL, icacile (ifudumele)
yoGcino Imeko 2-8 ° C
isicelo I-Urolithin B yiyimathumbu yentsholongwane yezibalo ze-ellagitannis kwaye ibonisa isenzo esinamandla se-anti-oxidant kunye ne-pro-oxidant kuxhomekeka kwinkqubo kunye neemeko. I-Urolithin B inokubonakalisa kwakhona i-estrogenic kunye / okanye imisebenzi echasene ne-estrogenic.
UXwebhu loVavanyo iyafumaneka

 

I-Urolithin B powder Inkcazo ngokubanzi

I-Urolithin B yi-urolithin, luhlobo lwezinto ezixutywe kwi-gut yomntu emva kokufakwa kweellagitannins-enokutya okufana nepomegranate, amagwebu, iidpons ezibomvu, iialnuts okanye i-oak-ubudala ebomvu yeewayini. I-Urolithin B ifumaneka kumchamo ngendlela ye-urolithin B glucuronide.

I-Urolithin B yenye yeentsholongwane zesisu ze-ellagitannins, kwaye ineziphumo ezichasayo zokuvuvukala kunye ne-antioxidant. I-Urolithin B inqanda umsebenzi we-NF-κB ngokunciphisa i-phosphorylation kunye nokuthotywa kwe-IcyBcy, kwaye icinezela i-phosphorylation ye-JNK, i-ERK, ne-Akt, kwaye iphucula i-phosphorylation ye-AMPK. I-Urolithin B ikwangumlawuli wemithambo yethambo. I-Urolithin B inokubonakalisa kwakhona i-estrogenic kunye / okanye imisebenzi echasene ne-estrogenic.

 

Imbali yomgubo we-Urolithin B

I-Urolithin B inokusetyenziswa njengechiza le-antitumor kunye ne-anticancer. I-Urolithin B (CAS NO: 1139-83-9) yi-urolithin, ikwaveliswa emathunjini omntu emva kokufakwa kwe-ellagitannins kwipomegranate. I-Urolithin B inokunciphisa ukonakala kwemisipha ngexesha lokuzilolonga kakhulu kwaye ikhusele izihlunu ngokuchasene noxinzelelo olubangelwa kukutya okunamafutha aphezulu.

I-Urolithin B powder nayo i-intestinal microbial metabolite ye-ellagitannis kwaye ibonisa i-anti-oxidant kunye ne-pro-oxidant activies ngokuxhomekeke kwinkqubo ye-assay kunye neemeko. I-Urolithin B inokubonisa i-estrogenic kunye / okanye i-anti-estrogenic. Ineziphumo ezichasene nokudumba kunye ne-antioxidant. I-Urolithin B ikwasetyenziselwa ukuba ibe sisilawuli semithambo yemisipha.

Kwaye i-Urolithin B ibonakalisiwe ukuba inqumle isithintelo segazi lobuchopho, kwaye inokuba nayo inkqubo yokhuselo Iziphumo ezichasene nesifo se-Alzheimer's.

 

Urolithin B powder Uphando olongezelelweyo

I-Urolithin B inokunciphisa ukonakala kwemisipha ngexesha lokuzilolonga kakhulu kwaye ikhusele izihlunu ngokuchasene noxinzelelo olubangelwa kukutya okunamafutha aphezulu. Uphando lwezonyango kwi-Urolithin B kwiimpuku lufumanise ukuba luphucula ukukhula kwe-myotubes kunye nokwahlula-hlula ngokwanda kweprotein synthesis. Ibonakalise amandla okuthintela indlela ye-ubiquitin – proteasome (UPP), indlela ephambili yeprotein catabolism. Ikwanyanzelise imisipha yehypertrophy kunye nokunciphisa i-muscle atrophy.

Xa kuthelekiswa ne testosterone, Urolithin B xa ithathwa kwi-15 uM yonyusa umsebenzi we-androgen receptor nge-90% ngelixa i-testosterone yayikwazi ukufeza kuphela umsebenzi owandayo we-50% kwi-100uM. Oku kuthetha ukuba kuthatha i-Urolithin B engaphantsi kakhulu ukunyusa umsebenzi we-androgen ngokukuko emva koko inani eliphezulu le-testosterone elonyusa umsebenzi we-androgen kancinci.

Ngaphaya koko, i-15uM esebenzayo kakhulu ye-Urolithin B yamandla aphambili emisipha nge-96% xa kuthelekiswa ne-100uM ye-insulin, eyakha inkqubo yemisipha yeproteni ngokusebenzisa kakhulu ama-61%. Inkolelo kukuba kuthatha ixesha elide kakhulu ukuba i-Urolithin B inyuse ukwandiswa kweprotheni yemisipha ngomgangatho ophezulu wokusebenza.

Olu phononongo lubonisa ukuba i-Urolithin B inokuyithintela i-protein catabolism ngelixa ngaxeshanye yandise ukwakheka kweprotein, sisithako sendalo esinceda ukwakha umsipha obuthathaka ngelixa uthintela ukuchitheka kwemisipha.

 

Isalathiso se-Urolithin B Powder 1139-83-9

  1. 1. UKallio, T., et al: J. Agr. Ukutya Chem., 61, 10720 (2013); I-Nealmongkol, P., et al: I-Tetrahedron, 69, 9277 (2013); ILarrosa, M., et al: J. Agr. Ukutya Chem., 54, 1611 (2006); IBialonska, D., okqhubekayo: J. Agr. Ukutya Chem., 57, 10181 (2009)
  2. URodriguez J, okqhubekayo. Urolithin B, umlawuli osanda kuchongwa wesisipha samathambo. J Imisipha yeCachexia Sarcopenia. Ngo-2017 Agasti; 8 (4): 583-597.
  3. IBialonska D, iKasimsetty SG, uKhan SI, uFerreira D (11 ngoNovemba 2009). "I-Urolithins, i-intestinal microbial metabolites ye-Pomegranate ellagitannins, ibonisa umsebenzi onamandla we-antioxidant kwisilingo esisekelwe kwiseli". J Agric Ukutya Chem. 57 (21): 10181-6.

 

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