iimveliso

I-Urolithin A Powder

I-Urolithin A, i-gut-microbial metabolite ye-ellagic acid, ine-anti-inflammatory, antiproliferative kunye ne-antioxidant. I-Urolithin A induces autophagy kunye neapoptosis, icinezela ukuqhubekeka komjikelo weseli, kwaye inqanda ukuhlanganiswa kweDNA. I-Urolithin A ayaziwa ukuba ifumaneka nakweyiphi na indawo yokutya. Ukufumaneka kwayo kokufumaneka ikakhulu kuxhomekeke kubume be-microbiota, kuba ziibacteria ezithile kuphela ezikwaziyo ukuguqula ii-ellagitannins zibe zii-urolithins.

Ukuvelisa: Imveliso yeBatch
ipakethe1KG / ibhegi, 25KG / igubu
Umgubo wobulumko unamandla okuvelisa nokubonelela ngobuninzi. Yonke imveliso phantsi kwemeko ye-cGMP kunye nenkqubo engqongqo yokulawula umgangatho, onke amaxwebhu okuvavanya kunye nesampuli ekhoyo.

Urolithin A powder Base Information

igama I-Urolithin A Powder
CAS 1143-70-0
Ukungcola 98%
Igama leKhemikhali I-3,8-Dihydroxybenzo [c] chromen-6-inye
Iintetho ezifanayo 3,8-dihydroxy-6H-dibenzo (b, d) ipyran-6-nye; I-3,8-DIHYDROXYDIBENZO- (B, D) IPYRAN-6-INYE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-inye; Umbala weCastoreum I; Urolithin A; I-6H-Dibenzo (B, D) i-pyran-6-nye, i-3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-nye); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) ipyran-6-inye
I-Molecular Formula C13H8O4
Isisindo somzimba 228.2
Indawo yokunyibilika > 300 ° C
InChI Key I-RIUPLDUFZCXCHM-UHFFFAOYSA-N
imo ziqinile
Kubonakala Umgubo oKhanyayo oMthubi
Ubomi obulicla
Umzimba I-soluble kwi-DMSO (3 mg / mL).
yoGcino Imeko Okomileyo, omnyama kunye no-0 ukuya ku-4 C okwexesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).
isicelo I-Urolithin A yintsholongwane ye-ellagitannin; Ii-Intermediates zamayeza
UXwebhu loVavanyo iyafumaneka

 

I-Urolithin A Powder Inkcazelo ngokubanzi

I-Urolithin A powder ngumxube we-metabolite ngenxa yokuguqulwa kwe-ellagitannins yi-gut gut bacteria kwaye i-inducer ye-mitophagy. I-Urolithin A ishenxisa i-mitochondria ukusuka kwi-CI- ukuya kwi-CII eqhutywa kukuphefumla, yandisa ixesha lokuphila kunye nokuphucula ukusebenza kwemisipha. Yeyeklasi yeekhompawundi eziphilayo ezibizwa ngokuba yi-benzo-coumarins okanye i-dibenzo-α-pyrones. Izanduleli zayo - i-ellagic acid kunye nee-ellagitannins- zikho kuyo yonke indawo kwindalo, kubandakanya nezityalo ezityiwayo, ezinje ngeerharnate, amaqunube, irasibheri kunye nama walnuts. Ukusukela nge-2000s, i-urolithin A ibisoloko iphantsi kwezifundo zokuqala ngokubhekisele kwiziphumo zebhayiloji.

I-Urolithin A powder inokuphucula umgangatho kunye nokusebenza kwe-mitochondria, kwaye yonyuse amandla kunye nonyamezelo lwezihlunu ezindala. Yiyo kuphela imveliso yendalo eqinisekisiweyo yokuqalisa kwakhona i-mitochondrial autophagy kunye nokuguqula ukuguga kwemisipha.

Ii-Urolithins zii-microflora metabolites zomntu zokutya ezivela kwi-ellagic acid, ezifana ne-ellagitannins. Ziveliswa kwifayile ye-

isisu somntu, kwaye safunyanwa kumchamo ngohlobo lwe-urolithin B glucuronide emva kokufakwa kokutya okune-ellagitannins

ipomegranate, i-strawberries, i-raspberries ebomvu, i-walnuts okanye i-oak ebomvu yewayini ebomvu.

Ngexesha le-metabolism yamathumbu ngamabhaktheriya, i-ellagitannins kunye ne-punicalagins ziguqulwa zaba yi-urolithins, ezingaziwayo

Umsebenzi webhayoloji kwi vivo ebantwini. Ii-Urolithins metabolites zerharnate ye-ellagitannins yendawo ngokukhethekileyo kwi

i-prostate gland, ikholoni, kunye namathumbu emathumbu emathumbu.

I-Ellagitannins ibonisa ukungabikho kwe-bioavailability esezantsi kwaye iguqulwa emathunjini iye kwi-ellagic acid kunye ne-microbiota metabolites yayo.

Ii-Urolithins zifumaneka kwi-plasma ubukhulu becala njenge-glucuronides kwiindawo eziphantsi.

Imveliso ye-Urolithins ixhomekeke kwi-gut microbiome enterotype. Abantu abavelisa ii-urolithin babonisa ubuninzi obuphezulu kakhulu

yeqela leClostridium leptum leFirmicutes phylum kuneBacteroides okanye iPrevotella

 

Urolithin Imbali yomgubo

Kwizifundo zebhubhoratri, i-urolithin A powder yaboniswa ukuba ifake i-mitophagy, eyona nto ikhethiweyo yokuphinda isebenze kwakhona ye-mitochondria nge-autophagy, inkqubo ecoca i-mitochondria enesiphene emva komonakalo okanye uxinzelelo, kwaye ihlala ingasebenzi kakuhle ngexesha lokuguga. [14] Esi siphumo siye saqwalaselwa kwiintlobo ezahlukeneyo zezilwanyana (iiseli ezanyisayo, iimpuku kunye no-elegans).

 

Urolithin A umgubo Isicelo

I-Urolithin I-powder yenzelwe ukusetyenziswa njengesithako ekukhetheni ukutya okanye ekusebenziseni ukutya okukhethekileyo kwimveliso yokutshintsha ukutya ngokusekwe kwimisebenzi yayo yesondlo ekuxhaseni impilo ye-mitochondrial jikelele.

 

Urolithin A powder Uphando olungakumbi

I-Urolithin A ayaziwa ukuba ifumaneka nakweyiphi na into yokutya. Ifom njengesiphumo sotshintsho lwe-ellagic acid kunye ne-ellagitannins sisisu se-microflora ebantwini. I-ellagic acid ngokwayo ibangelwa yi-hydrolysis yee-ellagitannins emathunjini phambi kwamanzi. [Ucaphulo]

Imithombo yeellagitannins zezi: iirharnate, amandongomane, amanye amajikijolo (iirisibisi, amaqunube, amaqunube amnyama, amaqunube), iti, iidiliya zemiscadine, iziqhamo ezininzi ezikweleenjiko, kunye newayini endala ye-oki (itheyibhile engezantsi).

Ukuguqulwa kwee-asidi ze-ellagic kwi-urolithin A kuxhomekeke kubume be-microflora nganye kwaye bunokwahluka kakhulu.

 

Urolithin A Powder Reference

  1. UPaller CJ, uPantuck A, uCarducci MA. Uphengululo lweerharnate kumhlaza webele. Umhlaza wedlala lobudoda Prostatic Dis. 2017 uMatshi 25. ikhonkco: 10.1038 / pcan.2017.19. [Epub phambi kokuprinta] Uphengululo. Ipapashwe kwi-PMID: 28440320.
  2. Ito H.Metabolites ye-ellagitannin geraniin kunye nemisebenzi yabo yokulwa ne-antioxidant. IPlanta Med. NgoJulayi 2011; 77 (11): 1110-5. ikhonkco: 10.1055 / s-0030-1270749. Epub 2011 Feb 3. Uphengululo. I-PMID epapashiweyo: 21294073.
  3. Ishimoto H, et al. Kwi-vivo iipropathi ezichasene nokudumba kunye ne-antioxidant ye-ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. Ngo-2011 ngo-Oktobha 1; 21 (19): 5901-4.

 

Amanqaku aKhanyayo