I-Orlistat powder (96829-58-2)

I-Orlistat powder (i-96829-58-2) ividiyo

 

I-Orlistat powder (96829-58-2) Ulwazi olusisiseko

igama	Orlistat
CAS	96829-58-2
Ukungcola	98%
Igama leKhemikhali	Orlistat
Iintetho ezifanayo	I-Tetrahydrolipstatin Xenical Alli
I-Molecular Formula	C29H53NO5
Isisindo somzimba	495.7 g / mol
Indawo yokunyibilika	/
InChI Key	AHLBNYSZXLDEJQ-FWEHEUNISA-N
imo	solid
Kubonakala	Umgubo omhlophe
Ubomi obulicla	Iiyure ezi-1-2
Umzimba	Ukunyibilika kwamanzi: Ngokukodwa ngokunganyibiliki
yoGcino Imeko	Gcina kwisitya esitywiniweyo somoya, gcina umoya ungaphandle, ukhuselekile kubushushu, ukukhanya kunye nokufuma.
isicelo	Sebenzisa ukunciphisa umzimba okanye uneengxaki zonyango ezinxulumene nobunzima
UXwebhu loVavanyo	iyafumaneka

 

I-Orlistat powder (96829-58-2) Inkcazo ngokubanzi

I-Orlistat powder sisiyobisi esenzelwe ukunyanga ukukhuluphala. Kuthengiswa njengeyeza elikhuselweyo njengelichiza phantsi kwegama lokurhweba ngeXenical nguRoche kumazwe amaninzi, kwaye kuyathengiswa ngaphezulu kwikhawuntara njengeAlli nguGlaxoSmithKline e-United Kingdom nase-United States.Its Umsebenzi oyintloko ukuthintela ukufakwa kwamafutha ku Ukutya komntu ngokusebenza njenge-lipase inhibitor, ngaloo ndlela kunciphisa umthamo we-caloric. Yenzelwe ukusetyenziswa ngokudibeneyo nomboneleli wokhathalelo wezempilo-ogadwe yinciphisa-ikhalori yokutya.

I-Orlistat powder sisithambiso esigciniweyo se-lipstatin, inhibitor yendalo enamandla e-pancreatic lipases esekwe kwi-bacterium Streptomyces toxytricini.However, ngenxa yobulula bayo kunye nokuzinza, i-orlistat powder yakhethwa ngaphezulu kwe-lipstatin yokuphuhliswa njengechiza elichasene nokukhuluphala.

 

I-Orlistat powder (96829-58-2) Imbali

I-Orlistat powder isetyenziselwa ukunceda ukunciphisa umzimba, okanye ukunceda ukunciphisa umngcipheko wokubuyisa ubunzima esele belahlekile. Eli liyeza kufuneka lisetyenziswe kunye nokutya okunekhalori okuncitshisiweyo. I-Orlistat yeyokusetyenziswa kuphela kubantu abadala.

 

I-Orlistat powder (96829-58-2) I-Mechanism of Action

I-Orlistat powder yinto eguqukayo enhibitor ye-lipases. Inika umsebenzi wayo wonyango kwi-lumen yesisu kunye namathumbu amancinci ngokwenza umdibaniso odibeneyo kunye nendawo esebenzayo ye-serine ye-gastric kunye ne-pancreatic lipases. Ii-enzymes ezingasebenziyo azifumaneki kumanqatha okutya e-hydrolyze ngendlela ye-triglycerides kwii-acids zamafutha asimahla kunye ne-monoglycerides. Njengoko i-triglycerides engafakwanga ingafakwanga, umphumo wekhalori onesiphumo unokuba nefuthe lokulawula ubunzima.

 

I-Orlistat powder (96829-58-2) Isicelo

I-Orlistat powder isetyenziswe ngovavanyo oluvunyiweyo ngugqirha, utshintsho lokuziphatha, kunye nenkqubo yokutya encinci yeekhalori zokukunceda ukunciphisa umzimba. Isetyenziswe ngabantu abathile abatyebileyo, njengabo batyeba kakhulu okanye baneengxaki zonyango ezinxulumene nobunzima. Ukuthatha i-orlistat kunokukunceda ukuba ungazukubuyisa isisindo esilahlekileyo. Ukuphulukana nobunzima kunye nokuwugcina kude kunganciphisa umngcipheko omkhulu wezempilo oza nokukhuluphala, kubandakanya isifo sentliziyo, isifo seswekile, uxinzelelo lwegazi oluphezulu, kunye nobomi obufutshane.

 

I-Orlistat powder (96829-58-2) Olunye uphando

Abantu banokucela "i-Dose Orlistat iyasebenza ngokwenene?".

Ukuba isetyenziswe kunye neqhinga elongezelelweyo lokulahleka kwesisindo, i-Orlistat ibonakalisiwe ukuba iyasebenza ekuncedeni ukunciphisa umzimba.

Olunye uphononongo lufumanise ukuba abantu abathathe i-Orlistat kwaye baqhubeka nokutya okune-calorie ephantsi baphulukene ne-1.25 yelitye (8.1kg) ngonyaka, eyayiyi-6lb (2.8kg) ngaphezulu kwabo bangazange bathathe i-Orlistat ngexesha elinye.

Olunye uphononongo lufumanise ukuba abaguli abangama-743 abatyebileyo abathatha i-Orlistat yokunciphisa umzimba baye baphulukana nomndilili we-10.3kg ubunzima emva konyaka. Oku kuthelekiswa nezigulana ezi-6.1kg ezingathathi i-Orlistat elahlekileyo.

Olunye uphononongo luye lwafumanisa ukuba abantu abalandela le khosi yonyango banokuphulukana ukuya kwi-10% yobunzima bomzimba wabo ngonyaka.

Njengamayeza amaninzi, kukho ezinye zeziphumo ze-Orlistat. Iziphumo eziqhelekileyo ezirekhodiweyo ze-Orlistat zokuthatha i-Orlistat zihlangabezana nentloko.

 

I-Orlistat powder (96829-58-2) Isalathiso

[1] I-Orlistat i-120mg capsule blister pack ". TGA. 11 Epreli 2000. Ibuyisiwe nge-18 ku-Epreli 2018.

[2] JA Menendez; L. Vellon; R. Lupu (2005). "Izenzo ze-Antitumoral ze-anti-obesity drug orlistat (i-Xenical TM) kwiiseli zomhlaza wamabele: ukuvinjelwa kokuqhubela phambili komjikelo weseli, ukukhuthaza ukubhubha kweseli kwe-apoptotic kunye ne-PEA3-mediated transcriptional transcriptional ye-Her2 / neu (erbB-2) oncogene". Izibhengezo zeOncology. 16 (8): 1253-1267. ikhonkco: 10.1093 / annonc / mdi239. IINKCUKACHA:

[3] ”I-FDA ivuma i-Orlistat yoSetyenziso oluNgaphezulu kweye-Counter” (Imithombo yeendaba). Ulawulo lwezoKutya kunye noLawulo lweziyobisi (FDA). Nge-7 kaFebruwari 2007. Ibuyisiwe nge-7 kaFebruwari 2007.

[4] USawule, uStephanie (7 ngoFebruwari 2007). "Amachiza okuThoba umzimba athengiswe ngaphezulu kweKhawuntari". INew York Times. Ukufunyanwa kwe-10 kaFebruwari 2007.