I-Galantamine powder (69353-21-5)

I-Galantamine inokhuphiswano kwaye iphinda ibangele i-acetylcholinesterase, ngaloo ndlela yandise uxinzelelo kunye nokunyusa isenzo se-acetylcholine (Ach).

Ukongeza, i-galantamine ligand ye-nicotinic acetylcholine receptors, enokuthi inyuse ukukhutshwa kwe-presynaptic ye-Ach kunye nokuvula ii-receptors ze-postynaptic.

Le arhente inokuthi iphucule umsebenzi we-neurocognitive kwisifo sika-Alzheimer esithambileyo kwaye esilinganiselweyo kwaye inokunciphisa iimpawu zokuthintela ukungakwazi ukuzikhupha emzimbeni ezikhuthaza ukubuyela umsi ngokutshaya.

I-Galantamine Hydrobromide powder yindlela ye-hydrobromide yetyuwa ye-galantamine, ialkaloid yomhlaba efunyanwa ngokuxutywe okanye ngokwemvelo ukusuka kwiibhulethi kunye neentyatyambo zikaNarcissus kunye nolunye uhlobo lwendlu ye-Amaryllidaceae yosapho ene-anticholinesterase kunye nemisebenzi eyandisa i-neurocognitive.

I-Galantamine yi-alkaloid ye-phenan mukomae kunye ne-reetyible, ekhuphisayo ye-acetylcholinesterase inhibitor.

Ayidibani nolwakhiwo kunye nezinye i-acetylcholinesterase inhibitors. Indlela yokusebenza kaGalantamine ecetywayo yesenzo ibandakanya ukubuyela umva kwe-acetylcholinesterase, ethintela i-hydrolysis ye-acetycholine, ekhokelela ekunyukeni kwengcinezelo ye-acetylcholine kwi-cholinergic synapses.

I-Galantamine ikwadibanisa konke kunye ne-nicotinic acetylcholine receptors kwaye inokubangela isenzo se-agonists (njenge-acetylcholine) kwezi receptors.

I-Galanthamine Hydrobromide esetyenziselwa ikakhulu i-myasthenia gravis, inqanaba le-poliovirus quiescent level kunye ne-sequela, ikwakhona kwi-polyneuritis, funiculitis kunye nesithintelo sensorimotor esibangelwa sisifo senkqubo ye-nervous system okanye i-traumatism.

Isetyenziswe kakhulu kwisifo se-Alzheimer, inomsebenzi ophambili wokudumba kunye ne-dysmnesia ebangelwa ngumonakalo wobuchopho.

I-Galantamine hydrobromide ichiza elichasene ne-anticholinesterase ngokusebenzisa isithintelo segazi-nengqondo, yindima yenkqubo ye-nervous system.

I-Galantamine hydrobromide ingasetyenziselwa abantwana abanesifo sokuqaqamba kwamalungu omzimba, umvandedwa wokuva ubunzima emzimbeni, iproperneuritis kunye ne-radiculitis, njl.

IAAA

• I-1, [Ukuphendula okukhulu kwe-cutaneous kwi-galantamine hydrobromide (Reminyl® kunye ne-generics)]. Schmutz JL et al. UAnn Dermatol Venereol. (2016)
• I-2, i-Galantamine-elayishwe ngokuqinileyo-lipid nanoparticles ukulungiselela ukuhanjiswa kwengqondo: ulungiselelo, umlinganiso, in vitro kunye novavanyo lwe-vivo. I-Misra S et al. Ukusetyenziswa kwesiyobisi. (2016)
• I-3, I-membrane ye-PVC, i-wire coated, kunye ne-carbon-paste ion-electrodes ezikhethiweyo zokumisela potentiometric ye-galantamine hydrobromide kulwelo lomzimba. UAdel-Haleem FM et al. Mater Sci Eng C Mater Biol Appl. (2018)
• I-4, Izifo zeParkinson. UShimohama S, Kawamata J. Ku: Akaike A, Shimohama S, Misu Y, abahleli. I-Nicotinic Acetylcholine Receptor Signaling kwi-Neuroprotection [kwi-Intanethi]. ESingapore: Springer; 2018. Isahluko 8. 2018 Aprili 4. PMID: 31314416