I-Galantamine powder (69353-21-5)

Ividiyo yeGalantamine Hydrobromide yomgubo

 

Ulwazi lweSiseko seGalantamine Hydrobromide

igama	I-Galantamine Hydrobromide powder
CAS	69353-21-5
Ukungcola	98%
Igama leKhemikhali	69353-21-5 5-Methoxy-9-methyl-2,3,3a,3a1,8,9,10,11-octahydro-4-oxa-9-azacycloocta[def]fluoren-2-ol hydrobromide
Iintetho ezifanayo	hydrobromide
I-Molecular Formula	C17H22BrNO3
Isisindo somzimba	368.3 g / mol
Indawo yokunyibilika	126-127ºC
InChI Key	I-DKGIHQCMWKXHHR-UHFFFAOYSA-N
imo	solid
Kubonakala	Powder
Ubomi obulicla	iiyure 16-20
Umzimba	Ichithwa ngokuthe ngqo kumanzi ashushu; i-solitle ngokunyanisekileyo, i-acetone, i-chloroform. I-sol encinane kwi-benzene, ether.
yoGcino Imeko	I-2-8 ° C, gcina isitya ngokuqinileyo kwindawo eyomileyo, ngaphandle kokukhanya.
isicelo	IGalantamine hydrobromid isetyenziselwa ukunyanga isifo sokuthoba isifo sengqondo esixhalabisayo sohlobo lwe-Alzheimer.
UXwebhu loVavanyo	iyafumaneka

 

IGalantamine Hydrobromide ingcaciso ngokubanzi

I-Galantamine inokhuphiswano kwaye iphinda ibangele i-acetylcholinesterase, ngaloo ndlela yandise uxinzelelo kunye nokunyusa isenzo se-acetylcholine (Ach).

Ukongeza, i-galantamine ligand ye-nicotinic acetylcholine receptors, enokuthi inyuse ukukhutshwa kwe-presynaptic ye-Ach kunye nokuvula ii-receptors ze-postynaptic.

Le arhente inokuphucula ukusebenza kwe-neurocognitive kwisifo se-Alzheimer esisulungekileyo nesingahambelaniyo kunye nokunciphisa iimpawu zokuqonda ezibangelwa kukuyeka ukutshaya.

 

Imbali yeGalantamine Hydrobromide powder

I-Galantamine Hydrobromide powder yindlela ye-hydrobromide yetyuwa ye-galantamine, ialkaloid yomhlaba efunyanwa ngokuxutywe okanye ngokwemvelo ukusuka kwiibhulethi kunye neentyatyambo zikaNarcissus kunye nolunye uhlobo lwendlu ye-Amaryllidaceae yosapho ene-anticholinesterase kunye nemisebenzi eyandisa i-neurocognitive.

 

I-Galantamine Hydrobromide Mechanism yesenzo

I-Galantamine yi-alkaloid ye-phenan mukomae kunye ne-reetyible, ekhuphisayo ye-acetylcholinesterase inhibitor.

Ayidibani nolwakhiwo kunye nezinye i-acetylcholinesterase inhibitors. Indlela yokusebenza kaGalantamine ecetywayo yesenzo ibandakanya ukubuyela umva kwe-acetylcholinesterase, ethintela i-hydrolysis ye-acetycholine, ekhokelela ekunyukeni kwengcinezelo ye-acetylcholine kwi-cholinergic synapses.

I-Galantamine ikwadibanisa konke kunye ne-nicotinic acetylcholine receptors kwaye inokubangela isenzo se-agonists (njenge-acetylcholine) kwezi receptors.

 

Isicelo seGalantamine Hydrobromide

I-Galanthamine Hydrobromide esetyenziselwa ikakhulu i-myasthenia gravis, inqanaba le-poliovirus quiescent level kunye ne-sequela, ikwakhona kwi-polyneuritis, funiculitis kunye nesithintelo sensorimotor esibangelwa sisifo senkqubo ye-nervous system okanye i-traumatism.

Isetyenziswe kakhulu kwisifo se-Alzheimer, sinomsebenzi oyintloko wesifo sengqondo kunye ne-dysmnesia ebangelwa ngumonakalo wengqondo.

 

I-Galantamine Hydrobromide Olunye uphando

I-Galantamine hydrobromide ichiza elichasene ne-anticholinesterase ngokusebenzisa isithintelo segazi-nengqondo, yindima yenkqubo ye-nervous system.

I-Galantamine hydrobromide ingasetyenziselwa abantwana abanesifo sokuqaqamba kwamalungu omzimba, umvandedwa wokuva ubunzima emzimbeni, iproperneuritis kunye ne-radiculitis, njl.

 

Isalathiso seGalantamine Hydrobromide Reference

• I-1, [Ukuphendula okukhulu kwe-cutaneous kwi-galantamine hydrobromide (Reminyl® kunye ne-generics)]. Schmutz JL et al. UAnn Dermatol Venereol. (2016)
• I-2, i-Galantamine-elayishwe ngokuqinileyo-lipid nanoparticles ukulungiselela ukuhanjiswa kwengqondo: ulungiselelo, umlinganiso, in vitro kunye novavanyo lwe-vivo. I-Misra S et al. Ukusetyenziswa kwesiyobisi. (2016)
• I-3, I-membrane ye-PVC, i-wire coated, kunye ne-carbon-paste ion-electrodes ezikhethiweyo zokumisela potentiometric ye-galantamine hydrobromide kulwelo lomzimba. UAdel-Haleem FM et al. Mater Sci Eng C Mater Biol Appl. (2018)
• I-4, Izifo zeParkinson. UShimohama S, Kawamata J. Ku: Akaike A, Shimohama S, Misu Y, abahleli. I-Nicotinic Acetylcholine Receptor Signaling kwi-Neuroprotection [kwi-Intanethi]. ESingapore: Springer; 2018. Isahluko 8. 2018 Aprili 4. PMID: 31314416