I-N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6)

I-N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) ividiyo

 

I-N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) Ulwazi oluSisiseko

igama	I-N-Acetyl-L-cysteine ​​ethyl ester
CAS	59587-09-6
Ukungcola	98%
Igama leKhemikhali	I-N-Acetyl-L-cysteine ​​ethyl ester I-NACET (R) -ethyl 2-acetamido-3-mercaptopropanoate
Iintetho ezifanayo	N-Acetylcysteine ​​ethylester; (R) -Methyl 2-acetaMido-3-Mercaptopropanoate -Ethyl 2-acetamido-3-mercaptopropanoate; Ethyl (2R) -2-Acetamido-3-Sulfanyl-Propanoate; (2R)--Acetamido-2-Mercaptopropanoic Acid Ethyl Ester; (3R)--Acetamido-2-Mercapto-Propionic Acid Ethyl Ester
I-Molecular Formula	C7H13NO3S
Isisindo somzimba	191.25 g / mol
Indawo yokunyibilika	197.0 ku-202.0 ° C
InChI Key	I-MSMRAGNKRYVTCX-LURJTMIESA-N
imo	solid
Kubonakala	I powder emhlophe
Ubomi obulicla	N / A
Umzimba	N / A
yoGcino Imeko	Gcina kwindawo epholileyo; Gcina isitya sivalekile kwindawo eyomileyo nenomoya owaneleyo
isicelo	I-N-Acetyl-L-cysteine ​​ethyl ester powder isetyenziselwa ukukhulisa inkumbulo, ukugxila, ubuchule bokuyila, ubukrelekrele kunye nenkuthazo.
UXwebhu loVavanyo	iyafumaneka

 

I-N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) Inkcazo ngokubanzi

I-N-Acetyl-L-cysteine ​​ethyl ester powder (NACET): i-cyophine ye-cysteine ​​yesenoveli evunyelweyo kunye neempawu ezithile ezingaqhelekanga ze-pharmacokinetic kunye namandla anokubakho e-antioxidant.

 

I-N-Acetyl-L-cysteine ​​ethyl ester Uphando ngakumbi

Uvavanyo lwakliniki olukhulu lwamva nje aluphumelelanga ukuqinisekisa iziphumo ezinokubakho ze-N-acetylcysteine ​​(NAC) ekuthinteleni izifo ezinxulumene noxinzelelo lwe-oxidative. Oku kungabangelwa kukuphazamiseka okuncinci kwe-bioavailability. Sasicinga ukuba i-esterization yeqela le-carboxyl le-NAC ukuvelisa i-N-acetylcysteine ​​ethyl ester (NACET) iya kuyonyusa kakhulu i-lipophilicity ye-NAC, ize ke iphucule kakhulu ikhemisi yayo. Kumsebenzi wangoku, sinika ingxelo ngepropathi ezimeleyo zamakhemikhali, ezezamayeza nezokulwa ii-anti-oxidant ze-NACET, ngakumbi ngokuthelekisa ngokuthe ngqo kunye ne-Ngengen yayo ye -gengener. Sifumanise ukuba i-NACET ingena ngokukhawuleza kwiigundane emva kolawulo lomlomo kodwa ifikelela kakhulu kwi-plasma. Oku kungenxa yempawu ezizodwa zeNACET: ingena ngokukhawuleza kwiiseli ekubanjiselwe ukuba iguqulwe ibe yi-NAC kunye ne-cysteine. Emva konyango ngomlomo, i-NACET (kodwa ingeyiyo i-NAC) yakwazi ukwandisa kakhulu umxholo we-glutathione uninzi lwezicubu ezivavanyiweyo, ubuchopho babandakanywa, kunye nokukhusela kwi-paracetamol inxication kwi-rat. I-NACET ikwanayo into ekhethekileyo yokuqokelelana kwii-erythrocyte zabantu apho isebenza njengomkhuseli onamandla nxamnye nomonakalo we-hydroperoxide-induction oxidative. Isifundo sethu sibonisa ukuba ukukwazi ukungena kwiiseli kunye nokuvelisa i-NAC kunye ne-cysteine, i-NACET inyuka ngokujikeleza kwe-hydrogen sulfide (H (2) S), yiyo loo nto imele umgqatswa olungileyo wokusetyenziswa komlomo njengomvelisi weH (2) S, kunye nezibonelelo ezicacileyo. ngaphezulu kwe-NAC. I-NACET inokubakho endaweni ye-NAC njenge-arhente ye-mucolytic, njenge-paracetamol antidote kunye njenge-antioxidant enxulumene ne-GSH.

 

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