I-Nicotinamide adenine dinucleotide (NAD) ipowder (53-84-9)

Ividiyo yeNicotinamide adenine dinucleotide powder

 

 

I-NAD powder (53-84-9) Ulwazi olusisiseko

igama	I-Nicotinamide adenine dinucleotide (NAD) powder
CAS	53-84-9
Ukungcola	99%
Igama leKhemikhali	I-beta-Diphosphopyridine nucleotide
Iintetho ezifanayo	IBeta-NAD NAD NAD+
I-Molecular Formula	C21H27N7O14P2
Isisindo somzimba	663.4 g / mol
Indawo yokunyibilika	I-160 ° C (320 ° F; 433 K)
InChI Key	BAWFJGJZGIEFAR-NNYOXOHSSA-N
imo	solid
Kubonakala	Powder
Ubomi obulicla	/
Umzimba	Ubuncwane bamanzi 2.14 mg / mL
yoGcino Imeko	kwisitya esingavaliweyo somoya, gcina umoya ungaphandle, ukhuselekile kubushushu, ukukhanya kunye nokufuma.
isicelo	inokunceda ukubuyela umva kweempawu zokwaluphala kunye nokunciphisa umngcipheko wezifo ezininzi ezinganyangekiyo
UXwebhu loVavanyo	iyafumaneka

 

I-NAD powder (53-84-9) Inkcazo ngokubanzi

Umgubo we-NAD, mfutshane kwi-nicotinamide adenine dinucleotide. Icoenzyme eyenzeka kwiiseli ezininzi eziphilayo kunye nemisebenzi njengesamkeli se-elektroni. I-powder ye-NAD isetyenziselwa enye i-NADH njenge-oxidizing okanye ukunciphisa i-arhente ekuphenduleni komzimba.

 

Imbali yeNicotinamide adenine dinucleotide

I-coenzyme NAD + yafunyanwa okokuqala ngoochwephesha bezinto eziphilayo baseBritane uArthur Harden kunye noWilliam John Young ngo-1906. Baye babiza into engaziwayo inoxanduva loku kwenza oku njenge coferment. Ngokuhlanjululwa okude kwaye kunzima ukusuka kwizicwili zegwele, le nto izinzileyo kubushushu yachongwa njenge-nucleotide iswekile phosphate nguHans von Euler-Chelpin. Kwi-1936, isazinzulu saseJamani u-Otto Heinrich Warburg wabonisa ukusebenza kwe-nucleotide coenzyme kudluliso lwe-hydride kwaye wachonga icandelo le-nicotinamide njengendawo yokuphendula kwakhona.

Izandulela ze-Vitamin ze-NAD + zachongwa okokuqala ngo-1938, xa uConrad Elvehjem wabonisa ukuba isibindi sinomsebenzi "wolwimi oluchasene nomnyama" ngendlela ye-nicotinamide. Emva koko, ngo-1939, wanika ubungqina bokuqala bokuba i-niacin isetyenziselwa ukuhlanganisa i-NAD +. Ekuqaleni kwee-1940, uArthur Kornberg waba ngowokuqala ukufumana i-enzyme kwindlela ye-biosynthetic. U-Lehninger uqinisekisile ukuba i-NADH idibanise iindlela ze-metabolic ezifana nomjikelo we-citric acid kunye nokuhlanganiswa kwe-ATP kwi-phosphorylation ye-oxidative. Ngo-1949, uJack Preiss noFilip Handler bafumanisa i-intermediates kunye ne-enzyme ezichaphazelekayo kwi-biosynthesis ye-NAD +; Ukuhlanganiswa kwe-salvage synthesis kwi-nicotinic acid kuthiwa yi-Preiss-Handler indlela. Ngo-1958, uCharles Brenner kunye nabo basebenza naye bafumanisa indlela ye-nicotinamide riboside kinase eya kwi-NAD.

 

I-NAD powder (53-84-9) Indlela yokusebenza

I-Nicotinamide adenine dinucleotide (NAD) ipowder ibandakanyeka kwiziphumo ze-redox, ethwele i-elektroni ukusuka ekuphenduleni komnye komnye. I-cofactor ke, ifunyenwe kwiifom ezimbini kwiiseli: I-NAD + yi-arhente yokukhupha i-oxidis- yamkela ii-elektroni kwezinye iimolekyuli kwaye iyancitshiswa. Ezi zinto zijongayo zenza i-NADH, enokusetyenziswa njengeziko lokunciphisa ukunikela ngee-elektroni. Ezi ntshukumo zodluliso lwe-elektroni zingumsebenzi ophambili weNAD. Nangona kunjalo, ikwasetyenziswa kwezinye iinkqubo zeselfowuni, ubukhulu becala luluhlu lwee-enzymes ezongeza okanye zisusa amaqela eekhemikhali kwiiproteni, kulungelelaniso lwasemva kokubhala. Ngenxa yokubaluleka kwale misebenzi, ii-enzymes ezichaphazelekayo kwimetabolism ye-NAD ziithagethi zokufumanisa iziyobisi.

 

Isicelo seNicotinamide adenine dinucleotide

I-Nicotinamide adenine dinucleotide (NAD) ipowder isebenza njengamafutha kwiinkqubo eziphambili zebhayoloji, ezifana:

1) Ukuguqula ukutya kube ngamandla

2) Ukulungiswa kweDNA eyonakalisiweyo

3) Ukuqinisa iinkqubo zokhuseleko lweeseli

4) Ukuseta iiwotshi zangaphakathi zomzimba wakho okanye isingqisho esijikelezayo

 

I-NAD powder (53-84-9) Uphando ngakumbi

Ngenxa yokuba uninzi lophando kwiNicotinamide adenine dinucleotide (NAD) powder ivela kwizifundo zezilwanyana, akukho zigqibo zicace gca zinokwenziwa malunga nokusebenza kwayo ebantwini. Nazi izibonelelo zempilo ezinokubakho zeNicotinamide adenine dinucleotide (NAD) powder:

1. Sebenzisa ii-Enzymes ezinokuKhuthaza ukuKhula kweMpilo

2. Ngamana Uncede ukukhusela iiSeli zeBongo

I-NAD + idlala indima ephambili ekuncedeni ubudala beeseli zakho zeengqondo.

Ngaphakathi kweeseli zobuchopho, i-NAD + inceda ukulawula imveliso ye-PGC-1-alpha, iprotein ebonakala ngathi iyanceda ukukhusela iiseli kuxinzelelo lwe-oxidative kunye nomsebenzi we-mitochondrial. Abaphandi bakholelwa ukuba zombini uxinzelelo lwe-oxidative kunye nokungasebenzi kakuhle kwe-mitochondrial kunxulunyaniswa nengxaki ezinxulumene nobudala ezinje ngesifo sika-Alzheimer's kunye nesifo sikaParkinson.

3. Ngamana Ngezantsi Umngcipheko weSifo seNhliziyo

Ukwaluphala yeyona nto iphambili kwisifo sentliziyo, esingoyena nobangela wokufa kwabantu ehlabathini. Inokubangela ukuba imithambo yegazi efana ne-aorta yakho iqine, iqine kwaye ingabi bhetyebhetye. Olo tshintsho lunokunyusa amanqanaba oxinzelelo lwegazi kwaye lwenze ukuba intliziyo yakho isebenze nzima.

Kwizilwanyana, ukunyusa i-NAD + kuncede utshintsho olunxulumene nobudala kwimithambo yegazi

4. Ingaphantsi komngcipheko womhlaza

Amanqanaba aphezulu e-NAD + anceda ukukhusela ngokuchasene nomonakalo weDNA kunye noxinzelelo lwe-oxidative, olunxulunyaniswa nophuhliso lomhlaza

5. Inokukhuthaza ukuguga kwemisipha esempilweni

Ukuphakamisa amanqanaba e-NAD + kuncede ukuphucula ukusebenza kwemisipha, amandla kunye nokunyamezela kwiigundane ezindala

 

Isalathiso seNicotinamide adenine dinucleotide Reference

• [1] USakuraba H, Kawakami R, Ohshima T (2005). "Okokuqala i-Archaeal Inorganic Polyphosphate / i-ATP-exhomekeke kwi-NAD Kinase, evela kwi-Hyperthermophilic Archaeon Pyrococcus horikoshii: Cloning, Expression, and Characterization". Appl. Indawo. Microbiol. 71 (8): 4352-8. ikhonkco: 10.1128 / AEM.71.8.4352-4358.2005. Isishwankathelo.
• [2] U-Katoh A, Uenohara K, Akita M, Hashimoto T (2006). "Amanyathelo okuqala kwi-Biosynthesis ye-NAD kwi-Arabidopsis Qala nge-Aspartate kwaye yenzeke kwi-Plastid". Utyalo lwePhysiol. 141 (3): 851-7. ikhonkco: 10.1104 / pp.106.081091. I-PMC 1489895. PMID 16698895.
• [3] Chen YG, Kowtoniuk WE, Agarwal I, Shen Y, Liu DR (Disemba 2009). "Uhlalutyo lwe-LC / MS lwe-RNA yeselula ityhila i-RNA enxulumene ne-NAD". UNat Chem Biol. 5 (12): 879-881. ikhonkco: 10.1038 / nchembio.235. I-PMC 2842606. PMID 19820715 (PubMed) (Umnqamlezo)
• [4] Gomes AP, Ixabiso NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA (19 ngoDisemba 2013). "Ukwehla kwe-NAD + kubangela iPseudohypoxic State iphazamise uNxibelelwano lwenyukliya-iMitochondrial ngexesha lokuguga". Iseli. 155 (7): 1624-1638. ikhonkco: 10.1016 / j.cell.2013.11.037. I-PMC 4076149. PMID 24360282.
• Yonke into ekufuneka uyazi ngeNicotinamide Riboside Chloride