I-Galantamine Hydrobromide powder (1953-04-4)

I-Galantamine hydrobromide powder yindawo ephezulu yealkaloid efunyenwe ibuchwephesha okanye ngokwemvelo ukusuka kwi-bulbs kunye neentyatyambo zikaNarcissus kunye nolunye uhlobo oluthile lwentsapho ye-Amaryllidaceae ene-anticholinesterase kunye nemisebenzi yokuphucula i-neurocognitive. I-Galantamine inokhuphiswano kwaye iphinda ibangele i-acetylcholinesterase, ngaloo ndlela yandise uxinzelelo kunye nokunyusa isenzo se-acetylcholine (Ach). Ukongeza, i-galantamine ligand ye-nicotinic acetylcholine receptors, enokuthi inyuse ukukhutshwa kwe-presynaptic ye-Ach kunye nokuvula ii-receptors ze-postynaptic. Le arhente inokuthi iphucule umsebenzi we-neurocognitive kwisifo sika-Alzheimer esithambileyo kwaye esilinganiselweyo kwaye inokunciphisa iimpawu zokuthintela ukungakwazi ukuzikhupha emzimbeni ezikhuthaza ukubuyela umsi ngokutshaya.

I-Galantamine Hydrobromide powder iyakwazi ukufumana kwi-bulb ye-leucojum a festivalum, umxholo ujikeleze i-0.1% ukuya kwi-2% kwisiseko esomileyo. Ngelixa iGalantamine Hydrobromide inomxholo ophezulu ukuya kwi-7.4% kwi-phaedranassa negistrophylla, elinye igama lesityalo iLycoris radiata. Nangona kunjalo, ezi zityalo zivela kwimithombo ebalulekileyo kwaye zikhuselwe ngurhulumente. Zingama-20 iintlobo ze-lycoris emhlabeni, kunye neentlobo ezili-16 eTshayina, ezifumana phakathi kwaye zifikelela kumazantsi oMlambo iYangtze. Izityalo eziluhlaza kule mihla ziyalinywa kwaye uninzi lwazo luyafumaneka. I-Lycoris radiata ngowona mthombo waziwayo wendalo wokukhupha i-Galantamine Hydrobromide.

Ke isebenza njani ngqo i-galantamine hydrobromide? Nangona isenzo sokulimala kwengqondo kwi-Alzheimer's (AD) asiqondwa ngokupheleleyo, kuye kwanikelwa ingxelo yokuba ii-acetylcholine ezenza imithambo-luvo ziwohloka ngaphakathi kweengqondo zezigulana ezine-Alzheimer's.

Iqondo lokulahleka kwe-cholinergic liyaqhubeka ukuhambelana nesixa sokulimala kwengqondo kunye nokuxinana kwamachaphaza amyloid (uphawu lwe-neuropathological uphawu lwe-Alzheimer's).

I-Galantamine hydrobromide ibopha i-electrosterate ukuya kwindawo esebenzayo ye-enzyme ye-cholinesterase. Ukubopha kubuye umva, ngenxa yoko kusebenza njenge-inhibitor yokhuphiswano eguqulweyo ye-cholineterase kwaye yandisa i-hydrolysis ye-endetyini acetylcholine, ke kukhula ukuqokelela kwayo kwaye yandise kwaye inike amandla kwiziphumo zayo, ezibonakaliswa kulungelelwaniso oluqhubekayo kunye nolwexesha elide kwinani le-cholinergic postynaptic membrane .

I-Galantamine hydrobromide ifunyenwe ukuba ikhuphe impembelelo ngqo kulwakhiwo oluthile lwe-CNS ene-nerve ye-cholinergic. Ukongeza, isebenza kwi-CNS ngendlela ekhanyayo, ezinokubangela impembelelo ezihambelanayo ezivela kwezinye iindawo ezinomda we-reflexogenic ..

1. I-Galanthamine Hydrobromide isetyenziswa ikakhulu kwi-myasthenia gravis, inqanaba le-poliovirus quiescent level kunye ne-sequela, ikwakhona kwi-polyneuritis, funiculitis kunye nesithinteli sensorimotor esibangelwa sisifo senkqubo ye-nervous system okanye i-traumatism.
2. I-Galanthamine Hydrobromide ikwasetyenziswa kwisifo i-Alzheimer's, inomsebenzi ophambili womba kunye nedysmnesia obangelwa ngumonakalo wobuchopho bezinto eziphilayo.

I-Galantamine iveliswa kwimithombo yendalo kunye nenkqubo yokuqamba yonke. Ezinye iindlela ezininzi zokwenziwa zikhoyo kodwa azange ziphunyezwe kwinqanaba lokuzenzela.

IAAA

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• Esona sikhokelo siphezulu se-Nootropic: Yonke into ekufuneka uyazi [amava emi-5]
• Ushwankathelo olugqibeleleyo kwiiNongezo zeNootropic iGalantamine Hydrobromide ngo-2020