I-Galantamine Hydrobromide powder (1953-04-4)

Ividiyo yeGalantamine Hydrobromide yomgubo

 

Ulwazi lweSiseko seGalantamine Hydrobromide

igama	I-Galantamine Hydrobromide powder
CAS	1953-04-4
Ukungcola	98%
Igama leKhemikhali	(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
Iintetho ezifanayo	I-Galanthamine Hydrobromide; UGalantamine HBr; UNivalin; URazadyne; Reminyl; Nivaline; Razadyne.
I-Molecular Formula	C17H22BrNO3
Isisindo somzimba	368.271 g / mol
Indawo yokunyibilika	126.5 ° C (259.7 ° F)
InChI Key	I-QORVDGQLPPAFRS-XPSHAMGMSA-N
imo	Powder
Kubonakala	Imhlophe ukuya kwi-Off-white powder
Ubomi obulicla	iiyure 7
Umzimba	Isisombululo kwi-DMSO, kungekhona emanzini
yoGcino Imeko	Okomileyo, omnyama kunye no-0 ukuya ku-4 C okwexesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).
isicelo	I-Galantamine (amagama e-Razadyne, i-Reminyl, kunye nabanye) asetyenziselwa ukunyanga ukwehla kwengqondo kwisifo se-Alzheimer esincinci ukuya kwezinye.
UXwebhu loVavanyo	iyafumaneka

 

IGalantamine Hydrobromide ingcaciso ngokubanzi

I-Galantamine i-hydrobromide powder yi-alkaloid ephakamileyo efunyenwe ngokwemvelo okanye ngokwemvelo kwiibhubhu kunye neentyatyambo zaseNarcissus kunye nezinye iindidi zeentsapho ze-Amaryllidaceae ezine-anticholinesterase kunye nemisebenzi yokuphucula i-neurocognitive. IGalantamine inokhuphiswano kwaye iphinda ibuye ibambe i-acetylcholinesterase, ngaloo ndlela yonyusa uxinzelelo kunye nokwenza ngcono isenzo se-acetylcholine (Ach). Ukongeza, i-galantamine ligam ye-nicotinic acetylcholine receptors, enokuthi inyuse ukukhutshwa kwe-Ach ye-presynaptic kunye nokuvula ii-postynaptic receptors. Le arhente inokuphucula ukusebenza kwe-neurocognitive kwisifo se-Alzheimer esisulungekileyo nesingahambelaniyo kunye nokunciphisa iimpawu zokuqonda ezibangelwa kukuyeka ukutshaya.

 

Imbali yeGalantamine Hydrobromide powder

I-Galantamine Hydrobromide powder iyakwazi ukufumana kwi-bulb ye-leucojum a festivalum, umxholo ujikeleze i-0.1% ukuya kwi-2% kwisiseko esomileyo. Ngelixa iGalantamine Hydrobromide inomxholo ophezulu ukuya kwi-7.4% kwi-phaedranassa negistrophylla, elinye igama lesityalo iLycoris radiata. Nangona kunjalo, ezi zityalo zivela kwimithombo ebalulekileyo kwaye zikhuselwe ngurhulumente. Zingama-20 iintlobo ze-lycoris emhlabeni, kunye neentlobo ezili-16 eTshayina, ezifumana phakathi kwaye zifikelela kumazantsi oMlambo iYangtze. Izityalo eziluhlaza kule mihla ziyalinywa kwaye uninzi lwazo luyafumaneka. I-Lycoris radiata ngowona mthombo waziwayo wendalo wokukhupha i-Galantamine Hydrobromide.

 

I-Galantamine Hydrobromide Mechanism yesenzo

Ke isebenza njani ngqo i-galantamine hydrobromide? Nangona isenzo sokulimala kwengqondo kwi-Alzheimer's (AD) asiqondwa ngokupheleleyo, kuye kwanikelwa ingxelo yokuba ii-acetylcholine ezenza imithambo-luvo ziwohloka ngaphakathi kweengqondo zezigulana ezine-Alzheimer's.

Iqondo lokulahleka kwe-cholinergic liyaqhubeka ukuhambelana nesixa sokulimala kwengqondo kunye nokuxinana kwamachaphaza amyloid (uphawu lwe-neuropathological uphawu lwe-Alzheimer's).

I-Galantamine hydrobromide ibopha i-electrosterate ukuya kwindawo esebenzayo ye-enzyme ye-cholinesterase. Ukubopha kubuye umva, ngenxa yoko kusebenza njenge-inhibitor yokhuphiswano eguqulweyo ye-cholineterase kwaye yandisa i-hydrolysis ye-endetyini acetylcholine, ke kukhula ukuqokelela kwayo kwaye yandise kwaye inike amandla kwiziphumo zayo, ezibonakaliswa kulungelelwaniso oluqhubekayo kunye nolwexesha elide kwinani le-cholinergic postynaptic membrane .

IGalantamine hydrobromide ifunyenwe inefuthe ngqo kwezinye izakhiwo ze-CNS ezinemithambo ye-cholinergic. Ukongeza, iyasebenza kwi-CNS ngendlela ye-reflex, enokubangela ukuba kufunyanwe iimpembelelo ezivela kwezinye iindawo ezibonisa umda.

 

Isicelo seGalantamine Hydrobromide

1. I-Galanthamine Hydrobromide isetyenziswa ikakhulu kwi-myasthenia gravis, inqanaba le-poliovirus quiescent level kunye ne-sequela, ikwakhona kwi-polyneuritis, funiculitis kunye nesithinteli sensorimotor esibangelwa sisifo senkqubo ye-nervous system okanye i-traumatism.
2. IGalanthamine Hydrobromide ikwasetyenziswa nakwisifo i-Alzheimer's, inomsebenzi ophambili wesifo sengqondo esixhalabisayo kunye nedysmnesia ebangelwa ngumonakalo wobuchopho bomzimba.

 

I-Galantamine Hydrobromide yoPhando ngakumbi

I-Galantamine iveliswa kwimithombo yendalo kunye nenkqubo yokuqamba yonke. Ezinye iindlela ezininzi zokwenziwa zikhoyo kodwa azange ziphunyezwe kwinqanaba lokuzenzela.

 

Isalathiso seGalantamine Hydrobromide Reference

• Li W, Zhou Y, Zhao N, Hao B, Wang X, Kong P. Ukuziphatha kwe-Pharmacokinetic kunye nokusebenza ngokuchanekileyo kwe-acetylcholinesterase inhibition kwi-rat kwengqondo emva kolawulo lwe-intranasal ye-galanthamine hydrobromide efakwe i-liposomes eguqukayo. I-Environ Toxicol Pharmacol. I-2012 Sep; 34 (2): 272-9. doi: 10.1016 / j.etap.2012.04.012. Epub 2012 Meyi 3. I-PubMed PMID: 22613079.
• URiemann D, uGann H, Ukunxiba uH, uMüller WE, uAldenhoff JB. Ukuchaphazeleka kwe-cholineterase inhibitor galanthamine hydrobromide kubuthongo obuqhelekileyo. Psychiatry Res. I-1994 Mar; 51 (3): 253-67. I-PubMed PMID: 8208872.
• I-Cozanitis DA. [I-Galanthamine hydrobromide: ithatha indawo ye-eserine sulphate (i-physostigmine) kunyango lweziphumo zesibeleko sezinto ezichasene ne-cholinergic]. Nouv Presse Med. Ngo-1978 ngoDisemba; 7 (45): 4152. IsiFrentshi. I-PubMed PMID: 745952.
• I-Cozanitis DA. I-Galanthamine hydrobromide, ichiza elisebenza ngokubambisa le-anticholinesterase, kunyango lweziphumo eziphambili ze-scopolamine (iHososcine). I-Anaesthesist. Ngo-1977 ngoDisemba; 26 (12): 649-50. I-PubMed PMID: 603022.
• Esona sikhokelo siphezulu se-Nootropic: Yonke into ekufuneka uyazi [amava emi-5]
• Ushwankathelo olugqibeleleyo kwiiNongezo zeNootropic iGalantamine Hydrobromide ngo-2020