I-Galantamine i-Hydrobromide powder yindlela yetyuwa ye-hydrobromide ye-galantamine, i-alkaloid ephezulu kunye ne-anticholinesterase kunye nemisebenzi yokuphucula i-neurocognitive. It is a alkaloid acetylcholinesterase inhibitor. IGalantamine inokhuphiswano kwaye iphinda ibuye ibambe i-acetylcholinesterase, ngaloo ndlela yonyusa uxinzelelo kunye nokwenza ngcono isenzo se-acetylcholine (Ach). Le arhente inokuphucula ukusebenza kwe-neurocognitive kwisifo se-Alzheimer esisulungekileyo nesingahambisiyo kwaye inokunciphisa iimpawu zokuqonda ezibangelwa kukuyeka ukutshaya.
igama | I-Galantamine Hydrobromide powder |
CAS | 1953-04-4 |
Ukungcola | 98% |
Igama leKhemikhali | (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
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Iintetho ezifanayo | I-Galanthamine Hydrobromide; UGalantamine HBr; UNivalin; URazadyne; Reminyl; Nivaline; Razadyne.
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I-Molecular Formula | C17H22BrNO3 |
Isisindo somzimba | 368.271 g / mol |
Indawo yokunyibilika | 126.5 ° C (259.7 ° F) |
InChI Key | I-QORVDGQLPPAFRS-XPSHAMGMSA-N |
imo | Powder |
Kubonakala | Imhlophe ukuya kwi-Off-white powder |
Ubomi obulicla | iiyure 7 |
Umzimba | Isisombululo kwi-DMSO, kungekhona emanzini |
yoGcino Imeko | Okomileyo, omnyama kunye no-0 ukuya ku-4 C okwexesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka). |
isicelo | I-Galantamine (amagama e-Razadyne, i-Reminyl, kunye nabanye) asetyenziselwa ukunyanga ukwehla kwengqondo kwisifo se-Alzheimer esincinci ukuya kwezinye. |
UXwebhu loVavanyo | iyafumaneka |
I-Galantamine i-hydrobromide powder yi-alkaloid ephakamileyo efunyenwe ngokwemvelo okanye ngokwemvelo kwiibhubhu kunye neentyatyambo zaseNarcissus kunye nezinye iindidi zeentsapho ze-Amaryllidaceae ezine-anticholinesterase kunye nemisebenzi yokuphucula i-neurocognitive. IGalantamine inokhuphiswano kwaye iphinda ibuye ibambe i-acetylcholinesterase, ngaloo ndlela yonyusa uxinzelelo kunye nokwenza ngcono isenzo se-acetylcholine (Ach). Ukongeza, i-galantamine ligam ye-nicotinic acetylcholine receptors, enokuthi inyuse ukukhutshwa kwe-Ach ye-presynaptic kunye nokuvula ii-postynaptic receptors. Le arhente inokuphucula ukusebenza kwe-neurocognitive kwisifo se-Alzheimer esisulungekileyo nesingahambelaniyo kunye nokunciphisa iimpawu zokuqonda ezibangelwa kukuyeka ukutshaya.
I-Galantamine Hydrobromide powder iyakwazi ukufumana kwi-bulb ye-leucojum a festivalum, umxholo ujikeleze i-0.1% ukuya kwi-2% kwisiseko esomileyo. Ngelixa iGalantamine Hydrobromide inomxholo ophezulu ukuya kwi-7.4% kwi-phaedranassa negistrophylla, elinye igama lesityalo iLycoris radiata. Nangona kunjalo, ezi zityalo zivela kwimithombo ebalulekileyo kwaye zikhuselwe ngurhulumente. Zingama-20 iintlobo ze-lycoris emhlabeni, kunye neentlobo ezili-16 eTshayina, ezifumana phakathi kwaye zifikelela kumazantsi oMlambo iYangtze. Izityalo eziluhlaza kule mihla ziyalinywa kwaye uninzi lwazo luyafumaneka. I-Lycoris radiata ngowona mthombo waziwayo wendalo wokukhupha i-Galantamine Hydrobromide.
Ke isebenza njani ngqo i-galantamine hydrobromide? Nangona isenzo sokulimala kwengqondo kwi-Alzheimer's (AD) asiqondwa ngokupheleleyo, kuye kwanikelwa ingxelo yokuba ii-acetylcholine ezenza imithambo-luvo ziwohloka ngaphakathi kweengqondo zezigulana ezine-Alzheimer's.
Iqondo lokulahleka kwe-cholinergic liyaqhubeka ukuhambelana nesixa sokulimala kwengqondo kunye nokuxinana kwamachaphaza amyloid (uphawu lwe-neuropathological uphawu lwe-Alzheimer's).
I-Galantamine hydrobromide ibopha i-electrosterate ukuya kwindawo esebenzayo ye-enzyme ye-cholinesterase. Ukubopha kubuye umva, ngenxa yoko kusebenza njenge-inhibitor yokhuphiswano eguqulweyo ye-cholineterase kwaye yandisa i-hydrolysis ye-endetyini acetylcholine, ke kukhula ukuqokelela kwayo kwaye yandise kwaye inike amandla kwiziphumo zayo, ezibonakaliswa kulungelelwaniso oluqhubekayo kunye nolwexesha elide kwinani le-cholinergic postynaptic membrane .
IGalantamine hydrobromide ifunyenwe inefuthe ngqo kwezinye izakhiwo ze-CNS ezinemithambo ye-cholinergic. Ukongeza, iyasebenza kwi-CNS ngendlela ye-reflex, enokubangela ukuba kufunyanwe iimpembelelo ezivela kwezinye iindawo ezibonisa umda.
I-Galantamine iveliswa kwimithombo yendalo kunye nenkqubo yokuqamba yonke. Ezinye iindlela ezininzi zokwenziwa zikhoyo kodwa azange ziphunyezwe kwinqanaba lokuzenzela.