I-Lorcaserin HCL powder (1431697-94-7)

I-Lorcaserin HCL powder (1431697-94-7) ividiyo

 

 

I-Lorcaserin HCL (1431697-94-7) Ulwazi olusisiseko

igama	I-LorcaserinHCL
CAS	1431697-94-7
Ukungcola	98%
Igama leKhemikhali	8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo [d] azepine hydrochloride
Iintetho ezifanayo	Lorcaserin Lorcaserin HCL Lorcaserin hydrochloride
I-Molecular Formula	C11H15Cl2N
Isisindo somzimba	232.15 g / mol
Indawo yokunyibilika	/
InChI Key	I-ITIHHRMYZPNGRC-UHFFFAOYSA-N
imo	solid
Kubonakala	Imhlophe ukuya kwi-Off-white powder
Ubomi obulicla	/
Umzimba	Ukunyibilika kwamanzi kungaphezulu kwama-400 mg / mL
yoGcino Imeko	Gcina kwiqondo lokushisa kwigumbi, kwisitya esitywiniweyo somoya, gcina umoya ungaphandle, ukhuselekile kubushushu, ukukhanya kunye nokufuma.
isicelo	I-Lorcaserin isetyenziswa ngovavanyo oluvunyiweyo ngugqirha, utshintsho lokuziphatha, kunye nenkqubo yokutya encinci yekhalori yokunceda ukunciphisa umzimba.
UXwebhu loVavanyo	iyafumaneka

 

I-Lorcaserin HCL powder Inkcazo ngokubanzi

I-Lorcaserin HCL powder ichaphazela imiqondiso yamachiza kwingqondo elawula ukuthanda ukutya. I-Lorcaserin HCL powder isetyenziswa kunye nokutya kunye nokuzivocavoca ukunyanga ukukhuluphala.

I-Lorcaserin ngamanye amaxesha isetyenziselwa ukunyanga ukukhuluphala okunokuba kunxulumene neswekile, cholesterol ephezulu, okanye uxinzelelo lwegazi oluphezulu.

 

I-Lorcaserin HCL powder (1431697-94-7) Imbali

I-Lorcaserin HCL sisiyobisi esilahlekelwa ngumzimba esiveliswe yiArena Pharmaceuticals.

 

I-Lorcaserin HCL powder Mechanism of Action

I-Lorcaserin HCL powder isebenza ngokukunceda uzive ugcwele kukutya okuncinci.

I-Lorcaserin yi-agonist ekhethiweyo ye-5-HT2C receptor agonist, kwaye kuvavanyo lwe-vitro ichiza labonisa ukukhetha okufanelekileyo kwe-5-HT2C ngaphezulu kwezinye iithagethi ezinxulumene.5-HT2C zifumaneka kuphela kwingqondo, kwaye inokufumaneka kwi-choroid plexus, icortex, hippocampus, cerebellum, amygdala, thalamus, kunye hypothalamus. Ukuvuselelwa kwee-receptors ze-5-HT2C kwi-hypothalamus kulindeleke ukuba kusebenze imveliso ye-proopiomelanocortin (POMC) kwaye ngenxa yoko kukhuthaza ukulahleka kwesisindo ngokusebenzisa i-satiety.Lolu xinzelelo luxhaswa zizilingo zeklinikhi kunye nezinye izifundo. Ngelixa kusoloko kucingelwa ukuba ii-receptors ezi-5-HT2C zinceda ukulawula ulangazelelo kunye nemozulu, kunye nokufihla kwe-endocrine, indlela echanekileyo yomgaqo wokunqwenela ukutya ayikaziwa. I-Lorcaserin ibonise ukukhetha kwe-100x ye-5-HT2C ngokuchaseneyo ne-5-HT2B receptor enxulumene, kunye nokukhethwa kwe-17x ngaphezulu kwe-5-HT2A receptor.

 

I-Lorcaserin HCL powder (1431697-94-7) Isicelo

I-Lorcaserin HCL powder isetyenziselwa ukuzivocavoca okuvunyiweyo ngugqirha, utshintsho lokuziphatha, kunye neprogram yokutya yokunciphisa ikhalori ukukunceda ukunciphisa umzimba. Isetyenziswa ngabantu abatyebe ngakumbi, njengabo batyebe kakhulu okanye baneengxaki zonyango ezinxulumene nobunzima. Ukunciphisa umzimba kunye nokukugcina kunganciphisa iingozi ezininzi zempilo eziza nokukhuluphala, kubandakanya isifo sentliziyo, isifo seswekile, uxinzelelo lwegazi kunye nobomi obufutshane. I-Lorcaserin HCL powder yeyeklasi yamachiza abizwa ngokuba yi-serotonin receptor agonists. Kucingelwa ukuba kusebenza ngokuchaphazela indawo ethile yobuchopho enceda ukulawula umdla wakho wokutya.

 

I-Lorcaserin HCL powder Ngakumbi uphando

I-Lorcaserin ayizukunyanga nayiphi na imeko yezempilo (njengesifo sentliziyo, isifo seswekile, uxinzelelo lwegazi oluphezulu).

 

I-Lorcaserin HCL powder (1431697-94-7) Reference

• [1] Ukutya okutsha iziyobisi iLorcaserin iphumelela ukuvota kwiPhaneli ye-FDA ”. webmd. Ngomhla we-10 kuCanzibe wama-2012. Kugcinwe kwindawo yokuqala nge-12 Meyi 2012.
• [2] ”Imiba ye-FDA Imbalelwano epheleleyo yeempendulo zeLorcaserin isicelo seDrug esitsha”. 23 Okthobha 2010. Kugcinwe kwindawo yokuqala nge-24 Oktobha 2010.
• [3] ”IBELVIQ kunye neBELVIQ XR Ikhasi lasekhaya leHCP”. www.yivdincm.com. Kugciniwe kwinto yoqobo ngowama-2016-06-16.
• [4] IBray, GA; UFrühbeck, G; URyan, DH; Wilding, JP (7 ngoMeyi 2016). "Ulawulo lokutyeba kakhulu". ILancet. 387 (10031): 1947-56. ikhonkco: 10.1016 / S0140-6736 (16) 00271-3. IINKCUKACHA:
• Isikhokelo sokuGqibela kweAlpha Lipoic Acid (ALA) ngo-2020