I-J147 powder (1146963-51-0)

igama	J147 powder
CAS	1146963-51-0
Ukungcola	98%
Igama leKhemikhali	2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Iintetho ezifanayo	N- (2,4-Dimethylphenyl) -2,2,2-trifluoro-N '- [(E) - (3-methoxyphenyl) methylene] acetohydrazide
I-Molecular Formula	C18H17F3N2O2
Isisindo somzimba	350.341 g / mol
Indawo yokunyibilika	177-178 ° C
InChI Key	HYMZAYGFKNNHDN-SSDVNMTOSA-N
imo	solid
Kubonakala	Imhlophe yomgubo ococekileyo omhlophe
Ubomi obulicla	I-1.5 hrs kwi-plasma kunye ne-2.5 hrs kwingqondo
Umzimba	Iinyibilika kwi-100 mM kwi-DMSO ukuya kwi-100 mM kwi-ethano
yoGcino Imeko	Gcina kwi-4 ° C
isicelo	Isiyobisi esilingayo kunye neziphumo ezixeliweyo nxamnye nesifo se-Alzheimer kunye nokwaluphala kwiimodeli zemouse zokuguga okukhawulezayo.
UXwebhu loVavanyo	iyafumaneka

Njengoko sele siphawulile apha ngasentla, i-J-147 powder sisiyobisi esilingayo. Ngamanye amagama, okwangoku ayifumaneki kumanani amakhulu kwimarike kwaye kusekho izinto ezininzi ezingekenziwa. I-J147 ibonwa njengonyango olunokwenzeka lwe-Alzheimer's kodwa inokuthengiswa njengesixhasi esijongene nokuguga.

I-J147 ibiphantsi kophuhliso ukusukela ngo-2011. Uphando malunga nokusebenza kwesiyobisi lusezantsi kakhulu. Kodwa siyayazi ukuba iyanceda ukuphinda yenze iiseli ezingqondweni zethu ngokubopha iiproteni zemochondria. Ukongeza, lonke uphando olwenziwe kwiziphumo ze-J147 lube kwimodeli zegundwane. Kude kubekho izilingo ezigcweleyo zabantu i-J147, kusekuninzi okunokubangela ukuba ungatyhileki. I-J147 synthesis isaqhubeka kwaye ichiza liyafumaneka kwi-Intanethi ukuze lithengwe.

Nangona uphando malunga nomsebenzi we-J147 njenge-Nootropics lusaza kuphuma kancinci, izazinzulu sele zikwazile ukubonisa ukuba zisebenza ngokuxhaphaza i-ATP, uhlobo lweproteyini efunyenwe kwi-mitochondria. Ngokutsho kwabaphandi, xa i-J147 yaziswa kwi-mitochondria, ii-neurons kwingqondo zazikhuselwe kwi-toxin ezihlala zihambelana nokuguga. Abaphandi bafumanise ukuba i-J147 trigger iphucula imveliso ye-ATP emzimbeni. Ichiza likwanokunceda ukuzinzisa i-mitochondria, into ebalulekileyo ekuchaseni ukuguga.

Ukubaluleka kwezi zenzo kubalulekile ngesizathu esinye. Kungenxa yokuba eyona nto ibangela uninzi lweAlzheimer, isifo sengqondo esixhalabisayo, kunye nezinye izifo zokugula kukuguga. Ukufumana indlela yokunciphisa okanye ukubuyisela umva iziphumo zokuguga kwingqondo kunokuba neziphumo ezihle kakhulu kunyango lwe-Alzheimer's. I-J147 ikwasetyenziselwa ukujolisa ekwakheni iproteni ye-beta-amyloid. Ukuqokelelwa okuphezulu kwale proteni kwizigulana zeAlzheimer kuye kwaxelwa kuphando lwangaphambili.

Kukho ubungqina obudibanisa esi sityholo sokuphazamiseka kwengqondo okuwohloka kubandakanya ne-Alzheimer's, isifo sikaParkinson nabanye. I-J147 Nootropic ijolise ekususeni ukuqokelelwa kwe-beta-amyloid plaque, yona inokunceda ukubuyisela umva okanye ukuthintela ukuqhubela phambili kweAlzheimer kunye neminye imiba yokuqonda. Eyona nto yenza ukuba i-J147 ibe sisiyobisi esithembisa kakhulu kukuba iyakwazi ukunyanga zonke iintlobo zengxaki yokuphazamiseka kwengqondo.

Okwangoku, uya kufuna unyango olwahlukileyo lokuphazamiseka kwengqondo okuhlukeneyo kwengqondo. Eyona nto ibalulekileyo, uya kufumana amayeza ka-Alzheimer's, Parkinson, nabanye. Kodwa i-J147 inokuba lonyango kuzo zonke ezi zifo. Uhlobo olunye lwamachiza anokunyanga ukuphazamiseka kwemithambo-luvo inokuba lutshintsho lomdlalo, kwaye i-J147 ikhangeleka ngathi ingayenza.

I-J147 inezibonelelo ezahlukeneyo ezinokubakho. Ichiza okwangoku liphuhliswa njengonyango lwe-Alzheimer's kodwa libonelela nangezinye izibonelelo ezifanelekileyo.

Apha:

UMeyi unokubuyisela umva ukuphazamiseka kweBongo

I-J147 ibonise isithembiso esininzi sokubuyisela umva impembelelo yokuphazamiseka kwengqondo kwi-neurodegenerative yengqondo njenge-Alzheimer's kunye nabanye. Kuvavanyo olwenziwe kwiimodeli zegundwane ukuza kuthi ga ngoku, ichiza libonise iimpembelelo ezintle ekujonganeni nale meko.

I-J147 isebenza ngokunceda iiseli ekubuyiselweni kwengqondo kwakhona, zizenze zincinci kwaye zisebenze ngakumbi kuneeseli ezindala. Nangona kunjalo, kubalulekile ukuba uqaphele ukuba akukho zilingo zomntu ezenziwe kwi-J147. Ngethemba, oko kuyakwenzeka kungekudala kodwa ichiza lisafumaneka ngokuthengiswa njengomgubo kubathengisi abakhethekileyo abakwi-Intanethi.

Ukuphucula isenzo seMitochondria kunye nokuPhila ixesha elide

I-J147 isebenza ngokubopha kwi-mitochondria, iiseli ezinoxanduva lokuvelisa amandla kwimizimba yethu. Isenzo se-J147 sinceda ukukhusela uxinzelelo lwe-oxidative kwiiseli ze-mitochondria, ezikhokelela ekusebenzeni ngcono kweseli kunye nokuphila ixesha elide.

I-J147 ikwanceda ukunciphisa i-metabolites eziyityhefu ezinokubangela ukugcwala kweseli, inkqubo leyo iiseli ezifa ngayo xa zidlula kakhulu. Oku kuvumela iiseli zakho ukuba zihlale zintsha kwaye zisempilweni ixesha elide. Ngapha koko, ezinye iindlela ezenziweyo kwizifundo zezilwanyana zabonisa ukuba ulawulo lwe-J147 kwiimpukane zeziqhamo luyolula ixesha labo lobomi nge-9.5 ukuya kwi-12.8%.

Iphucula Inkumbulo

I-J147 ikwabonakalise isithembiso esikhulu phakathi kweemodeli zeemouse zokuphucula imemori. Eli chiza lide lanceda ukuguqula imeko ebukhali yokuqonda kwengqondo kwizifundo zovavanyo ezindala ngexesha lophando.

Abaphandi bakholelwa ukuba ezi ziphumo zinokuthi ziphindaphindwe kwizifundo zabantu. Kukho ubungqina obucebisa ukuba i-J147 inokuphononongwa njengonyango olunokwenzeka kwimemori yendawo.

Ikhusela i-Neurons kwaye inceda ukukhula kweBongo

I-J147 ikwanepropathi ye-neuroprotective ethintela isenzo se-oxidative ngaphakathi kweeseli. Oku kunceda ukukhusela i-neurons kumonakalo onokwenzeka. I-J147 inokuba sisizathu sokukhula kwengqondo. I-J147 inokuphucula imeko ye-synaptic yengqondo kwingqondo, ekhokelela ekukhuleni.

Ukusukela i-J147 iseyilo ichiza lokulingwa, akukho ndlela yokwazi ithamo elifanelekileyo ukuza kuthi ga ngoku. Ayikho indlela yokwazi ukwenza i-J147. Ngaphandle koko, asibonanga naluphi na uvavanyo lweklinikhi lwe-J147 ebantwini.

Nangona kunjalo, ichiza sisixhasi esisebenza ngomlomo, oko kuthetha ukuba simele ukungeniswa emlonyeni. Kwiimvavanyo zovavanyo ze-J147 ezenziwe kwiimpuku, izifundo zovavanyo zanyangwa nge-J147 dosage ye-10 mgs ye-kilogram ubunzima bomzimba ngosuku. Oku akuthethi ukuba idosi esemgangathweni. Kungangcono ukubonisana nodokotela wakho phambi kokuqala ukusebenzisa i-J147.

I-J147 ngenene yinguqu eguqulweyo ye-curcumin, imolekyulu efumaneka kwi-turmeric. I-Curcumin kudala idityaniswa nomsebenzi ophuculweyo wengqondo. Iimolekyuli zinoxanduva lokuphucula amanqanaba e-BDNF, into ethathwe kwingqondo yeNootropic enokubaluleka ekubuyiseni ukugula kwengqondo.

Olunye lolona phando lwamva nje kwi-J147 lujonga iintshukumo zamachiza kwinqanaba leeselula. Iphepha elapapashwa ngo-2018 lamisela ukuba i-J147 isebenza ngokubopha kwiproteni kwi-mitochondria.

Intshukumo yenzelwa ingxelo yokuba inokubanamandla okuvuselela iiseli zobuchopho. Olunye uphando lwenziwe kwiimodeli zemouse malunga ne-J147 kunye namandla ayo okunyanga ukuphazamiseka kwengqondo kunye ne-Alzheimer's. Yayithembisa kakhulu.

I-Curcumin derivative J147 ifumaneka njengomgubo kumthengisi we-Wisdomepowder okhethiweyo kwi-Intanethi. Nangona kunjalo, kubalulekile ukuba unakekele ngakumbi ukuze ufumane imveliso efanelekileyo. Abathengisi be-Nootropics powder abathengise kangangexesha elithile kufuneka babe phezulu kuluhlu lwakho.

Jonga uphononongo lwabanye abasebenzisi kwakhona. Ufuna ukuthenga kubathengisi abanokuphononongwa okuninzi okuqinisekileyo kwiinyanga ezili-12 ezidlulileyo. Ixabiso le-J147 liyahluka ukusuka kumthengisi ukuya kwelinye.

• "Uvavanyo lwechiza ekujolise kulo isifo sika-Alzheimer lubonisa iimpembelelo zokulwa ukuguga" (Ukukhutshwa kweendaba). Iziko leSalk. Ngomhla we-12 ku-Novemba ngo-Novemba ka-2015.
• UJoshua Goldberg et al. I-synopase ye-mitochondrial ye-ATP yinto ekujoliswe kuyo ekwabelwana ngayo ngamachiza okwaluphala kunye nesifo sengqondo esiyingozi. Iseli yokuguga, i-2018 DOI: 10.1111 / acel.12715
• I-Oxiracetam Nootropics: Yonke into ekufuneka uyazi malunga nale Nootropic Kwintsapho yeRacetam
• Esona sikhokelo siphezulu se-Nootropic: Yonke into ekufuneka uyazi [amava emi-5]