iimveliso

Umgubo weFisetin (528-48-3)

I-Fisetin yinto eqhelekileyo ye-polyphenol ye-botanical kunye ne-flavonoid efumaneka kwizityalo ezahlukeneyo, iziqhamo kunye nemifuno kubandakanya amaqunube, ii-apile, ii-persimmon, amatswele kunye neekomkomere. I-Fisetin ithathwa njengesityalo sombala esinika iziqhamo kunye nemifuno emininzi, enje ngamaqunube, ngombala wazo kunye nokubonakala kwawo. I-Fisetin inesakhiwo semolekyuli esifana nesona sithandwa kakhulu sesityalo i-flavonoid kunye ne-Quercetin yokutya. Ngokungafaniyo neQuercetin, nangona kunjalo, i-Fisetin inokuba yi-senolytic kwaye mhlawumbi yenye yezona zinamandla ze-senolytics ezaziwayo.

Ukuvelisa: Imveliso yeBatch
ipakethe1KG / ibhegi, 25KG / igubu
Umgubo wobulumko unamandla okuvelisa nokubonelela ngobuninzi. Yonke imveliso phantsi kwemeko ye-cGMP kunye nenkqubo engqongqo yokulawula umgangatho, onke amaxwebhu okuvavanya kunye nesampuli ekhoyo.

1.Yintoni iFisetin?

2.Indlela yokusebenza yeFisetin: Isebenza njani iFisetin?

3.Kukuphi ukutya okuqulethe iFisetin?

4.Ziziphi iingenelo zeFisetin?

5.Fisetin Vs Quercetin: ngaba i-fisetin iyafana ne-quercetin?

6.Fisetin Vs Resveratrol: ngaba i-fisetin ingcono kune-resveratrol?

7.Fisetin kunye nokulahlekelwa kwesisindo

8.Ingakanani ifisetin ekufuneka ndiyithathe: Idosi yefisetin?

9.Ziziphi iziphumo ebezingalindelekanga zefisetin?

I-10.I-fisetin powder kunye ne-fisetin izongezo kwi-intanethi

 

I-Fisetin Chemical Base Information Ulwazi loLwazi

igama Umgubo weFisetin
CAS 528-48-3
Ukungcola 65%, 98%
Igama leKhemikhali 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
Iintetho ezifanayo 2- (3,4-dihydroxyphenyl) -3,7-dihydroxychromen-4-inye, 3,3 ′, 4 ′, 7-Tetrahydroxyflavone, 5-Deoxyquercetin, Natural Brown 1, CI-75620, NSC 407010, NSC 656275, I-BRN 0292829, iCotinin, 528-48-3 (anhydrous)
I-Molecular Formula C15H10O6
Isisindo somzimba 286.24
Indawo yokunyibilika 330 ° C (umhla wokugqibela)
InChI Key GYHFUROKCOMWNQ-UHFFFAOYSA-N
imo solid
Kubonakala Amandla ePowder
Ubomi obulicla /
Umzimba I-Soluble kwi-100 mM kwi-DMSO nakwi-10 mM kwi-ethanol
yoGcino Imeko -20 ° C ixesha elide
isicelo I-Fisetin sisixhobo esinamandla sokusebenza kwe-sirtuin (STAC), i-arhente yokulwa nokudumba kunye neyeza
UXwebhu loVavanyo iyafumaneka

 

I-Flavonoid polyphenols ngokuqhelekileyo isetyenziselwa iipropathi zabo ze-antioxidant. Umthombo wabo oyintloko ziziqhamo kunye nemifuno esetyenziswa rhoqo, zizigidi kwihlabathi jikelele. Ngenxa yeenzuzo zabo zempilo, i-flavonoids iye yaba zizithako eziphambili kwizongezo zokutya ezahlukeneyo, ngakumbi i-resveratrol. Uphononongo lwakutsha nje lufumene i-flavonoid entsha ebizwa ngokuba yifisetin, ekukholelwa ukuba yeyona inamandla phakathi kwezinye iiflavonoids ezisetyenziswa njengesongezelelo sokutya. I-Fisetin powder okanye izongezelelo zeFisetin ziye zanyuka kwimfuno ngenxa yeenzuzo zabo zempilo.

 

Yintoni iFisetin?

IFisetin yiflavonoid polyphenol esebenza njengebala elityheli kwizityalo. Ekuqaleni yafunyanwa ngo-1891, i-fisetin ifumaneka kwiziqhamo ezininzi kunye nemifuno efana ne-persimmon kunye namaqunube. Nangona ibikhona ixesha elide, bekukutsha nje ukuba izibonelelo zefisetin zifunyenwe kwaye zayenza yagqama xa ithelekiswa nezinye izongezo. Ngaphezu koko, yayiyinzuzo yonyango ye-fisetin powder eyakhuthaza uphando kwisihloko. Nangona ifundwe kwaye izibonelelo ze-fisetic kunye neziphumo ebezingalindelekanga ze-fisetin ziye zafezekiswa, kusekho okuninzi apho izazinzulu zingakhange zikwazi ukuyiqonda malunga ne-flavonoid.

 

Indlela yokusebenza yeFisetin: Isebenza njani iFisetin?

I-Fisetin powder isebenza ngeendlela ezininzi emzimbeni womntu. I-Fisetin isebenza ngakumbi kumanqanaba e-antioxidants emzimbeni kwaye le yenye yeenzuzo zayo ezinkulu. Ilwa neeradicals zamahhala, eziziioni ezingazinzanga eziya kuthatha inxaxheba kwiimpendulo zemichiza ezinobungozi ukulimaza umzimba. Iipropathi ze-antioxidant zeFisetin ziyivumela ukuba ithintele ezi radicals zasimahla kwaye ngenxa yoko, yehlisa uxinzelelo lwe-oxidative ophantsi kwayo umzimba.

Enye indlela yokwenza i-fisetin kukuba ivala indlela ye-NF-KB. Le ndlela ibalulekile kwimveliso kunye nokukhululwa kwe-cytokines e-pro-inflammatory kwaye ekugqibeleni, ukuvuvukala. I-NF-KB yindlela yokuvuvukala ebangela ukukhutshelwa kofuzo ukwenza iiprotheni ezivuthayo. Xa ivuliwe ngokugqithisileyo, indlela ye-NF-KB idlala indima ebalulekileyo ekuphuhliseni umhlaza, i-allergies, kunye nezifo ezizimelayo. I-Fisetin powder ivimbela le ndlela, ngoko ke, isebenza njenge-anti-inflammatory supplement.

I-Fisetin powder iphinda ivimbele isenzo sendlela ye-mTOR. Le ndlela, ifana nendlela ye-NF-KB, ibandakanyeka kuphuhliso lomhlaza, isifo seswekile, ukutyeba, kunye nezifo ze-neurodeergenerative. Indlela ye-mTOR ibangela ukuba iiseli zoyike njengoko zisokola ukuhlangabezana neemfuno zamandla zendlela, okukhokelela kumthwalo ogqithisileyo kwiiseli. Oku kuthetha ukuba iiseli zisebenza kakhulu kwaye zivelisa inkunkuma ye-metabolic kodwa akukho xesha laneleyo lokucoca inkunkuma ekhokelela ekuqokeleleni kwenkunkuma. Oku kunokuba yingozi kwimpilo yeselula kunye nokuvalwa kwale ndlela nge-fisetin supplement yindlela i-fisetin inceda ngayo ukulawula ukutyeba, isifo sikashukela kunye nomhlaza.

Ngaphandle kwezi ndlela zinkulu zesenzo, i-fisetin nayo iyakwazi ukuthintela umsebenzi we-lipid-degrading enzymes, i-lipoxygenases. Ikwanqanda i-matrix metalloproteinases okanye intsapho ye-MMP yee-enzymes. Ezi enzyme zibalulekile ukuba iiseli ezinomhlaza zikwazi ukuhlasela ezinye izicubu, nangona kunjalo, ngokusetyenziswa kwe-fisetin powder, oko akusenakwenzeka.

 

Kukuphi ukutya okuqulethe iFisetin?

I-Fisetin yi-flavone esekelwe kwisityalo ekhutshwe ngokuyinhloko kwii-apula kunye ne-strawberries. Libala lombala otyheli kunye ne-ocher kwizityalo, okuthetha ukuba uninzi lweziqhamo kunye nemifuno yalo mbala zityebile kwifisetin. I-Fisetin, kwizityalo, yenziwe kwi-amino acid phenylalanine, kwaye ukuqokelelwa kwale flavone kwizityalo kuxhomekeke kakhulu kwindawo yesityalo. Ukuba isityalo sibonakaliswe kubude obufutshane bemitha ye-UV, ngoko kukho ukwanda kwimveliso ye-fisetin. I-fisetin powder yenziwe ngokuhlukana kwe-fisetin kwimithombo yezityalo elandelayo.

 

Imithombo yezityalo Isixa seFisetin

(μg /g)

I-Toxicodendron vernicifluum 15000
Ndingathanda ipere yezinto zokukhafula kwiishethi 160
iapile 26
I-Persimmon 10.6
Itswele 4.8
Ingcambu yeLotus 5.8
Amagilebhisi 3.9
Isiqhamo 2.0
iphitshi 0.6
Netyhukhamba 0.1
tomato 0.1

 

Ziziphi iingenelo zeFisetin?

Izibonelelo zeFisetin zimbalwa, kwaye zonke zibonwe kwiimodeli zezilwanyana. Akukho phando luye lwakwazi ukumisela ngokugqibeleleyo ezi zibonelelo ebantwini njengoko uninzi lwezifundo zisakwisigaba sezonyango. Iintlobo ezahlukeneyo zefisetin ziquka:

 

Ukulwa nokuguga

Ukuguga komzimba kuphawulwa ngokunyuka komnatha kwiiseli ze-senescent, ezingasakwazi ukwahlula. Ezi seli zikhupha imiqondiso yokuvuvukala, ekhokelela kwiingxaki zokuguga ezibonwa ngokuqhelekileyo. Uninzi lweengxaki ezinxulumene nobudala zibangelwa kukudumba okunyanyekayo emzimbeni okhuthazwa ziiseli zeseli. Ukusetyenziswa kwe-fisetin powder kujoliswe kula maseli kwaye asuse emzimbeni, ngoko ke, ukunciphisa ukuvuvukala kunye nokunciphisa inkqubo yokuguga.

 

Ulawulo lwesifo seswekile

Kwiimodeli zezilwanyana, isongezelelo se-fisetin sibonakaliswe ukunciphisa amanqanaba eswekile yegazi kakhulu. Esi siphumo se-fisetin sivela kwisakhono se-flavonoid sokunyusa amanqanaba e-insulin, ukwandisa i-glycogen synthesis, kunye nokunciphisa amandla esibindi ukuqalisa i-gluconeogenesis. Ngokusisiseko, i-fisetin isebenza kuyo yonke indlela emzimbeni ekhokelela ekuveliseni i-glucose kwaye imise abo ngelixa ivula iindlela ezinokuthi zigcine okanye zisebenzise i-glucose egazini.

 

Unyango lomhlaza

Iziphumo ezichasene nomhlaza we-fisetin powder ziyahluka ngokusekelwe kuhlobo lomhlaza. Kuphononongo olwenziwa kumhlaza wedlala lengqula, i-fisetin yakwazi ukunciphisa ukukhula komhlaza ngokuthintela i-testosterone kunye ne-DHT receptors, ezibalulekileyo ekukhuleni komhlaza wedlala lesinyi. Kolunye uphononongo apho umhlaza wawufundwa ngumhlaza wemiphunga, izongezelelo ze-fisetin zakwazi ukunyusa i-antioxidants egazini eliye lancitshiswa kukusetyenziswa kwecuba. I-Fisetin nayo yakwazi ukunciphisa ukukhula komhlaza wemiphunga ngama-67 ekhulwini ngokwayo, kunye neepesenti ze-92 xa idibene neyeza le-chemotherapy. Xa isetyenziselwa umhlaza wekoloni, i-fisetin yanciphisa kakhulu ukukrala okuhambelana nomhlaza wekoloni. Uphononongo, nangona kunjalo, aluzange lukhankanye nayiphi na impembelelo ye-fisetin ekukhuleni komhlaza.

 

Neuroprotective

Xa iigundane ezidala kunye nokuncipha okunxulumene neminyaka ekuqondeni zanikwa isongezelelo se-fisetin, kukho ukuphucuka okukhulu kwizakhono zabo zokuqonda kunye nememori. Kolunye uphononongo, iimodeli zezilwanyana ziye zavezwa kwizinto ezine-neurotoxic emva koko zanikwa isongezelelo se-fisetin. Izifundo zovavanyo zifunyenwe ukuba azizange zifumane ukulahlekelwa kwememori ngenxa yokongeza. Nangona kunjalo, akwaziwa ukuba i-fisetin inokuwela umqobo wegazi-ingqondo yomntu kunye nokusebenza okufanayo kunye nesithintelo segazi-ingqondo yeempuku.

I-Fisetin ikwayi-neuroprotective ngengqiqo yokuba ikhusela ukuphuhliswa kweengxaki ze-neurodeergenerative ezifana ne-Alzheimer's ngokunciphisa ukuqokelela kweeprotheni eziyingozi kwingqondo. Ngokufanayo, iigundane ezine-ALS zibonise ukuphuculwa kokulungelelaniswa kwazo kunye nokulungelelaniswa kwemisipha emva kokunikwa i-fisetin powder. Kwakhona baye baphila ubomi obude kunoko kwakulindelekile.

 

I-Cardioprotective

Abaphandi bafunde umphumo we-fisetin powder kumanqanaba e-cholesterol eegundane ezondliwa ngokutya okunamafutha aphezulu. Amanqanaba e-cholesterol ewonke kunye ne-LDL afunyaniswe ehlile kakhulu ngelixa amanqanaba e-HDL aphantse aphinda kabini. Indlela eqikelelwayo apho i-fisetin ikhupha umzimba we-cholesterol kukholelwa ukuba yonyusa ukukhutshwa kwayo kwinyongo. I-cholesterol encitshisiweyo, ngokubanzi, inefuthe le-cardioprotective.

Zonke ezi zibonelelo ze-fisetin zikhomba ekuchaseni ukuguga kunye nobomi obude obufanele ukuba bube ngokwaneleyo ukukhuthaza izifundo zeklinikhi ezininzi ukuze ikhompawundi ivunywe ukuba isetyenziswe ngamayeza.

 

I-Fisetin Vs Quercetin: ingaba i-fisetin iyafana ne-quercetin?

I-Quercetin kunye ne-Fisetin zombini i-flavonoids yezityalo okanye i-pigments eyaziwayo ngokuchasa ukudumba kunye ne-anti-oxidant. Zombini zineempawu ezichasene nokuguga, ezizenzayo ngokucoca iiseli zencindi emzimbeni. I-Fisetin powder, nangona kunjalo, ibonakaliswe ukucima iiseli ngokunyuka kokusebenza kunye namandla kune-quercetin.

 

I-Fisetin Vs Resveratrol: ngaba i-fisetin ingcono kune-resveratrol?

I-Resveratrol yipolyphenol ekwadume kakhulu kwiipropathi zayo zokulwa ne-oxidant. Ukuthatha i-quercetin kunye ne-resveratrol kubangela umphumo we-synergistic kumzimba, nangona i-quercetin inamandla ngakumbi ekubaleni ukuvuvukala kunye nokulawula ukuxhathisa kwe-insulin. Ekubeni i-Fisetin ingcono ekwenzeni le misebenzi kune-quercetin, kunokugqitywa ukuba i-fisetin supplement ingcono kune-quercetin. iserveratrol supplements.

 

I-Fisetin kunye nokulahlekelwa kwesisindo

Abaphandi bafunde umphumo we-fisetin powder ekuqokeleleni kwamafutha emzimbeni kwaye kwafunyaniswa ukuba ivimba iindlela ezithile zokunciphisa ukutyeba okunxulumene nokutya. Ijolise kwindlela yomqondiso we-mTORC1. Le ndlela ibalulekile ekukhuleni kweeseli kunye ne-lipid synthesis, ngenxa yoko, ikhuthaza ukuqokelelwa kwamafutha emzimbeni.

 

Ingakanani ifisetin ekufuneka ndiyithathe: Idosi yefisetin?

I-Fisetin dosage ranges phakathi kwe-2 mg ukuya kwi-5 mg, ngekhilogram yobunzima, nangona kunjalo, oku akusiyo isikhokelo esicetyiswayo somlinganiselo. Akukho sincomo sithe ngqo sokusebenzisa i-fisetin, kwaye ukuthetha nengcali yezonyango kuya kunceda ekumiseleni uluhlu lwedosi ye-fisetin, engqamene neemeko zomntu. Kwesinye sezifundo eziqhutywe ngenjongo yokuvavanya umphumo we-fisetin powder kwi-inflammation ebangelwa ngumhlaza wekoloni, i-100 mg ngosuku yayifuneka ukuba ibone ukunciphisa okukhulu kokuvuvukala.

 

Ziziphi iziphumo ebezingalindelekanga zefisetin?

I-Fisetin mva nje yaba ngumxholo wezifundo ezininzi kunye neenxalenye ezahlukeneyo zophando. Lo mdla kade kwi-flavonoid uthetha ukuba uninzi lwezifundo ezenziweyo bezikwimodeli yezilwanyana okanye kwindawo yelebhu. Azikho izifundo ezininzi zomntu ezenziweyo ukumisela ngokucacileyo iziphumo ebezingalindelekanga kunye netyhefu yesongezo. Iimodeli zezilwanyana ekuvezweni kwimilinganiselo ephezulu ye-fisetin supplement ayizange ibonise nayiphi na imiphumo emibi, ebhekiselele kukhuseleko lokuncedisa.

Nangona kunjalo, kubalulekile ukukhumbula ukuba ukungabikho kwemiphumo emibi kwiimodeli zezilwanyana akuthethi ukuba umngcipheko wemiphumo emibi ebantwini awukho. Ukufikelela kweso sigqibo, izifundo ezininzi zeklinikhi kufuneka zenziwe. Kwisifundo esithile esasenziwe kwizigulane zomhlaza ukuhlola ukusebenza kwe-fisetin powder ekulawuleni iimpawu zomhlaza, zombini i-placebo kunye namaqela okulawula achaza ukungahambi kakuhle kwesisu. Ekubeni umphumo wecala wawukhona kumaqela omabini, kwaye amaqela omabini ayephantsi kwe-chemotherapy ngexesha elifanayo, kunzima ukugqiba ukuba ukusetyenziswa kwe-fisetin powder kunokubangela ukuphazamiseka kwesisu.

I-Fisetin powder ayinakuba nayo nayiphi na imiphumo emibi echazwe kodwa isebenzisana neziyobisi ezithile, okubangelwa ukuguqulwa kwemetabolism yaloo mayeza. I-Fisetin yafunyaniswa ukuba yehlisa amanqanaba eswekile yegazi kwiimodeli zezilwanyana, eluncedo kakhulu ngokwayo. Kodwa xa kuthathwa ngokubambisana namayeza achasene neswekile, i-glucose-reduction effect of both, isongezelelo kunye neziyobisi zinokugqithiswa. Oku kunokukhokelela kwiingxaki ezininzi zempilo.

I-powder ye-Fisetin i-metabolized ngesibindi, ngendlela efanayo, ukuba i-blood thinners i-metabolized. Ngenxa yoko, kucatshangelwa ukuba ezi zimbini ziza kusebenzisana kunye kunye ne-Fisetin powder iya kwandisa imiphumo ye-blood-thinning agents.

 

I-Fisetin powder kunye ne-fisetin izongezo kwi-intanethi

I-fisetin powder inokuthengwa kwi-intanethi kubakhiqizi abahlukeneyo be-fisetin powder, ngobungakanani obusekelwe kwimfuno ethile. Ukuthenga izixa zefisetin isambuku kunokuncedisa kumaxabiso ngokunjalo. Ixabiso likaFisetin alikho ngaphandle koluhlu, kwaye likuluhlu olufanayo nezinye izongezo ze-flavonoid.

Xa ujonge ukuthenga isongezelelo se-fisetin, kubalulekile ukujonga ngokucokisekileyo ngabavelisi be-fisetin powder kunye nenkqubo yabo yokuvelisa. Oku kukuqinisekisa ukuba izikhokelo zokhuseleko ezifanelekileyo kunye neeprothokholi zokuvelisa ziyalandelwa ngexesha lokuveliswa kwe-fisetin supplement. Kubalulekile ukuthenga i-fisetin powder ecocekileyo njengoko isenzela esona songezo se-fisetin. Ukuba umthengisi akalandeli iiprothokholi zokhuseleko kwi-extractions kunye ne-synthesis ye-fisetin, imveliso yokugqibela inokungcoliswa okanye ingcoliswe izithako ezinobungozi kwimpilo yabantu okanye ayinayo impembelelo kwimpilo yabantu, nantoni na. Nokuba yeyiphi na indlela, izibonelelo ze-fisetin aziyi kuba nakho ngaphandle kokuthatha isongezelelo ixesha elide.

Kuhlala kubalulekile ukujonga izithako ze-fisetin powder ezithengwayo kunye nomlinganiselo wokuxinana kwezi zithako ukuqinisekisa ukuba i-fisetin powder ecocekileyo iyathengwa. Ukuba lo mahluko awenziwanga, ngoko kukho ithuba elikhulu lokunyuka kwemiphumo emibi ye-fisetin kunye / okanye ukunciphisa izibonelelo ze-fisetin, ngokubanzi.

 

Ucaphulo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261287/

https://pubmed.ncbi.nlm.nih.gov/29275961/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780350/

https://link.springer.com/article/10.1007/s10792-014-0029-3

https://pubmed.ncbi.nlm.nih.gov/29541713/

https://pubmed.ncbi.nlm.nih.gov/18922931/

https://pubmed.ncbi.nlm.nih.gov/17050681/

https://pubmed.ncbi.nlm.nih.gov/29559385/