iimveliso
I-Pterostilbene powder (537-42-8)
2.Yintoni iPterostilbene powder?
3.Yintoni indlela yokusebenza yePterostilbene?
5.Ziziphi iingenelo zokuthatha iPterostilbene?
6.Ziziphi izibonelelo zePterostilbene eluswini?
7.Ingaba iPterostilbene ilungile kwingqondo?
8.Is iPterostilbene ilungile ekulahlekeni kobunzima
9.Pterostilbenefits ekukhuleni kweenwele
11.Pterostilbene iziphumo ebezingalindelekanga
15.Kukuphi ukutya okuqulathe iPterostilbene?
16.Ithathwe kwiyiphi iPterostil?
17.Imithombo yePterostilbenenatural
18.Ingaba iPterostilbene yiphytoestrogen
19.I-Pterostilbene ngamafutha anyibilikayo
20.Ngaba iPterostilbene yamanzi iyanyibilika?
21.Ngaba iPterostilbene iyayonyusa i-LDL?
22.Ingaba iPterostilbenelowder blood pressure?
23.Ingaba iPterostilbene iyingozi
24.Ingakanani iPterostilbene ekufuneka ndiyithathe?
25.Pterostilbenewith okanye ngaphandle kokutya?
26.Ngaba kufuneka uthathe iPterostilbene?
27.Leliphi elona xesha losuku lokuthatha iPterostilbene?
28.Zeziphi izongezo eziqulathe iPterostilbene?
29.Ingaba iPterostilbene ingcono kuneResveratrol?
30.Ngubani ongafanelekanga ukuthatha i-resveratrol
31.Ingakanani i-resveratrol ekhuselekileyo?
32.Pterostilbene kunye caffeine
33.Pterostilbene kunye nequercetin
36.Pterostilbene kunye neNicotinamide riboside
37.Ungayithenga phi iPterostilbene?
Pterostilbene powder (537-42-8) ividiyo
I-Pterostilbene kuthiwa ingcono kune-resveratrol. Bayibiza ngokuba ligazi lenamba, okanye nomthombo wobutsha. Ngaba uyafuna ukwazi ngakumbi ngePterostilbene? Nantsi i-37 FAQ ekufuneka uyazi:
1. Yintoni iPterostilbene?
I-Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) yipolyphenol eyenzeka ngokwemvelo, uhlobo lwemolekyuli eyenzeka kwizityalo. Iyingxenye yeqela le-stilbene leekhompawundi kunye neyona nto iphambili ye-antioxidant ye-blueberries. Kwizityalo, isebenza kwi-antimicrobial ekhuselayo kunye nendima ehlala i-antioxidative.
I-Pterostilbene yafunyanwa okokuqala ngo-1977 nguLangcake kunye noPryce kwaye yafundelwa iipropathi zayo ze-antioxidant kunye neenzuzo zempilo ezinokubakho.
I-Pterostilbene inxulumene neekhemikhali kwi-resveratrol, esinye isongezelelo sokutya esithandwayo; olunye uphando lucebisa ukuba lunokuba luncedo ngakumbi kwimpilo kunobudlelwane bayo obusondeleyo, ngamanye amaxesha inika ingcebiso yokuba inokuba "yi-resveratrol engcono".
Olona ncedo luphambili lwePterostilbene lunokushwankathelwa ngolu hlobo lulandelayo:
| 1 | I-Pterostilbene yinto yendalo efumaneka kubungakanani obuncinci kwimifuno kunye neziqhamo ezinje ngeblueberries. |
| 2 | I-Pterostilbene yimolekyuli encinci engcono kune-resveratrol ngokufunxa kunye nokuzinza. |
| 3 | I-Pterostilbene eyandisiweyo ubomi kwizinto ezahlukeneyo eziphilayo. |
| 4 | I-Pterostilbene inokunciphisa ukuvuvukala. |
| 5 | I-Pterostilbene inokuphucula ukulungiswa kwe-DNA. |
| 6 | I-Pterostilbene inokuvula ii-sirtuins, eziyi-enzymes ezilungisa i-DNA, iphucula imetabolism kwaye inokwandisa impilo kunye nobomi. |
| 7 | I-Pterostilbene inokuphucula ukusebenza kwengqondo kwaye inokukhusela ingqondo. |
| 8 | I-Pterostilbene inokunciphisa ukuqokelelwa kweeprotheyini, enye yezinto eziqhuba ukwaluphala. |
| 9 | I-Pterostilbene yenza i-AMPK, i-enzyme ebalulekileyo enokukhusela iiseli ekugugeni. |
| 10 | 10. I-Pterostilbene yonyusa imveliso ye-antioxidant enzymes enamandla, ikhusela iiseli ekonakalisweni kwe-oxidative. |
2. Yintoni iPterostilbene powder?
I-Pterostilbene powder yimathiriyeli ekrwada yePterostilbene enombala omhlophe.
I-Pterostilbene powder (537-42-8) Ulwazi olusisiseko
| igama | I-Pterostilbene powder |
| CAS inani | 537-42-8 |
| Ukungcola | 98% |
| Igama leKhemikhali | I-Pterostilbene （Dimethylresveratrol） |
| Iintetho ezifanayo | I-3,5-Dimethoxy-4-stilbenol, 3,5-Dimethoxy-4-hydroxy-E-stilbene |
| I-Molecular Formula | C16H16O3 |
| Isisindo somzimba | 256.3 g / mol |
| Indawo yokunyibilika | 89-92 ° C |
| InChI Key | VLEUZFDZJKSGMX-ONEGZZNKSA-N |
| imo | Powder |
| Ubomi obulicla | Umzimba |
| yoGcino Imeko | khusela ukukhanya, 2-8 ° C |
| isicelo | Ukusebenza kwangaphambili, izongezelelo zokwakha umzimba, izinto zokuthambisa |
| COA,HPLC | iyafumaneka |
| Pterostilbene
powder |
 |
3. Yintoni indlela yokusebenza yePterostilbene?
I-Pterostilbene yipolyphenol, uhlobo lwesimolekyuli esenzeka kwizityalo, ngakumbi amajikijolo amancinci kunye namandongomane. I-Blueberries ngowona mthombo utyebileyo wepterostilbene; nangona ifumaneka kwiidiliya, i-pterostilbene (ngokungafaniyo nomzala wayo) ayiphili inkqubo yokwenza iwayini.
Yintoni polyphenol? I-"Phenol" ibhekisa kwisakhiwo esithile seekhemikhali (kule meko, iqela le-hydroxyl elidityaniswe kwindandatho ye-benzene); "I-poly" ichaza nje ukuba iimolekyhule zinengaphezulu kwesinye kwisakhiwo. Omnye wemisebenzi ephambili yeepolyphenols kukunceda isityalo silwe neentsholongwane. Xa ityiwa ngabantu, i-polyphenols inokusebenza njengee-antioxidants ezinamandla.
Izazinzulu bezazi ezi zinto ukusukela ekuqaleni kwenkulungwane ye-19- uJoseph Lister, onguvulindlela wotyando lwe-antiseptic, waxela ngepropathi enye yokubulala intsholongwane ngo-1867- nangona igama elithi "polyphenol" alizange libe nokusetyenziswa kokurekhodwa kokuqala de kwangowe-1894.
Njengazo zonke iipolyphenols, abaphandi abayiqondi ngokupheleleyo indlela ipterostilbene esebenza ngayo. UGqirha Jose M. Estrela, unjingalwazi wezomzimba kwiYunivesithi yaseValencia (eSpain) oye wafunda i-pterostilbene uthi “into elungileyo kukuba i-pterostilbene iyasebenza, kodwa into embi kukuba asinako ukuzichaza ngokupheleleyo izibonelelo zempilo ezinokubakho ngolwazi esinayo. ”
4. Yintoni i Pterostilbene sebenzisa for?
I-Pterostilbene inokunceda ukukhusela kwisifo se-Alzheimer kunye nokuncipha kwengqondo ehambelana nokuguga, ngokutsho kophando olusekelwe kwizilwanyana olupapashwe kwi-Neurobiology of Aging ngo-2012. Kwiimvavanyo kwiigundane, ababhali bophando bafumanisa ukuba i-pterostilbene inokunceda ukugcina umsebenzi wokuqonda, ngokuyinxenye ngokunciphisa. ukudumba.
5. Ziziphi iingenelo zokuthatha iPterostilbene?
Izibonelelo ezininzi ze-pterostilbene kunyango kunye nothintelo lwesifo somntu ziye zabangelwa yi-antioxidant, anti-inflammatory, kunye ne-anticarcinogenic properties ezikhokelela ekusebenzeni okuphuculweyo kweeseli eziqhelekileyo kunye nokuvinjelwa kweeseli ezinobungozi.
Izifundo ezahlukeneyo zibonise i-antioxidant, i-anti-inflammatory, kunye ne-anticarcinogenic properties ye-pterostilbene, ekhokelele ekusebenzeni okuphuculweyo kweeseli eziphilileyo kunye nokuvinjelwa kweeseli ezinobungozi.
1) Izibonelelo zePterostilbene kwimpilo yentliziyo
I-Pterostilbene iye yabandakanyeka kwimpilo yentliziyo. ngophononongo oluthile olubonisa ukuba lunempembelelo yokukhusela kwi-atherosclerosis kunye nolunye lubonisa ukuba luphucula iinkalo ze-autophagy kwaye lunceda ukuchasana nefuthe le-pro-atherosclerosis ye-oxidized low-density lipoprotein kwiiseli ze-vascular endothelial. Ikwabonise usetyenziso olunokubakho ekunyangeni ukwenzakala kwe-ischemia-reperfusion.
2) Izibonelelo zePterostilbene kwi Isifo se-Alzheimer
Uphononongo lukwabonise amandla e-pterostilbene ngokunxulumene neemeko ze-neurodeergenerative ezifana nesifo se-Alzheimer. Uphononongo kwiimpuku ezinokuguga okukhawulezileyo lubonise ukuba i-pterostilbene, nakwidosi ephantsi, inefuthe elibalulekileyo ekuphuculeni amandla okuqonda.
3) I-Pterostilbene inokuphucula ukuqonda
Olunye uphononongo lucebisa ukuba i-pterostilbene ibandakanyeka kwi-neural plasticity kunye nemisebenzi ehambelana nayo yokuqonda kunye neemoto kunye nokuba iimpuku ezinikwe i-pterostilbene zisebenza ngcono kuvavanyo lwengqondo.
4) I-Pterostilbene yinto enamandla yokuchasana nokudumba
I-Pterostilbene yinto enamandla yokuchasana nokudumba kwaye inokucinezela i-NF-Kb, iprotein complex elawula ukubhalwa kwe-DNA, ukuveliswa kwe-cytokine kunye nokusinda kweeseli. Uphononongo lwakutsha nje lubonise ukuba i-pterostilbene inokunyanga i-pancreatitis ebukhali ngokunciphisa amanqanaba e-serum ye-TNF-a, i-IL-1b, kunye ne-NF-kB kwaye iyanciphisa ukuveliswa kweentlobo ze-oksijini ezisebenzayo.
I-Pterostilbene ikwanedatha ethile ecebisa ukuba inokuba luncedo ekunyangeni isifo samathambo, kwaye inikwe iipropathi zayo ezichasayo, ayothusi ke le nto. Ngelixa uphando lunqunyelwe ukuza kuthi ga ngoku malunga nesifo samathambo, uphononongo lwamagundane lucebise ukuba kunokwenzeka ukunyanga le meko.
5) I-Pterostilbene inokunceda ilahleko
Uphononongo lwakutsha nje olwenziwe kwizigulana ezine-hypercholesterolemia, zingathathi iyeza lokulwa ne-cholesterol, lafumanisa ukuba xa zongezwa ngePterostilbene, ezi zifundo zovavanyo zibonise inani elikhulu lokulahleka kobunzima. Oku kwalatha kwisibonelelo sokulahleka kwesisindo sekhompawundi yamachiza.
Olunye uphononongo olwenziwe kwiimodeli zezilwanyana ezongezwe nge-Pterostilbene powder lubonise ukonyuka okukhulu kwi-Akkermansia muciniphila yabemi emathunjini emodeli yezilwanyana. Ukubaluleka kolu hlobo kukuba kunciphisa umngcipheko wokukhuluphala, kunye nokuphucula impilo yonke yamathumbu.
6) I-Pterostilbene iphucula ukusebenza kwentliziyo
Iimpawu zePterostilbene ze-antioxidant ziluncedo ngakumbi entliziyweni, njengoko zinciphisa uxinzelelo lwe-oxidative kwilungu. Izifundo kwiimodeli zezilwanyana zibonise ukunciphisa okukhulu ukusilela kwentliziyo yemiphunga, okubangelwa luxinzelelo entliziyweni kukungasebenzi kwemiphunga.
7) I-Pterostilbene ikhusela iimpawu kumbono
Okwangoku, kukho izifundo ezininzi ezijolise kumandla ale polyphenol ekunciphiseni ukwenzeka kobumfama kwizigulana ezinesifo seswekile. Isidingo solu pho nonongo saphakanyiswa ngenxa yesinye isifundo esingqina ukuba iPterostilbene inciphisa ukuvuvukala kwi-cornea. Oku kufunyanisiweyo kukhokelele kubaphandi abanyanzela ukusetyenziswa kwePterostilbene powder kunyango lweliso elomileyo.
6. Ziziphi iingenelo zePterostilbene eluswini?
I-Pterostilbene cream ene-Pterostilbene powder yayisebenza kakhulu ekunciphiseni iimpawu zokwaluphala kwaye yenza ithoni yolusu. Imveliso yayisebenza kakuhle ekunciphiseni imibimbi kunye nemigca emihle, ukuphuculwa kwe-skin hydration elasticity kwaye ayibonisi miphumo emibi.
7. Ngaba iPterostilbene ilungile kwingqondo?
Ewe, iPterostilbene ilungile kwingqondo. I-Pterostilbene inokuphucula ukusebenza kwengqondo kwaye inokukhusela ingqondo. I-Pterostilbene inokunciphisa ukuqokelelwa kweeprotheyini, enye yezinto eziqhuba ukwaluphala. I-Pterostilbene yenza i-AMPK, i-enzyme ebalulekileyo enokukhusela iiseli ekugugeni.
8. Ngaba i-Pterostilbene ilungele ukunciphisa umzimba
I-Pterostilbene ivelise iziphumo ezilungileyo zokuncipha kobunzima kuphononongo olunye ubuncinci, kodwa izifundo ezinkulu kunye nezomelele ngakumbi ziyafuneka ukuze kuqinisekiswe ukusebenza kwayo.
Kuphononongo lwabantu abakubudala obuphakathi abane-cholesterol ephezulu, abo bebengathathi amayeza e-cholesterol balahlekelwe sisixa esincinci, kodwa esibalulekileyo, sobunzima ngelixa besongezelela nge-pterostilbene. Esi siphumo sasimangalisa, njengoko olu phononongo aluzange lwenzelwe ukulinganisa i-pterostilbene njengoncedo lokunciphisa umzimba. Esi siphumo ayikaphandwa kuphononongo olwahlukileyo.
Izifundo zeeseli kunye nezilwanyana zikwacebisa ukuba i-pterostilbene inokunceda ukuphucula ubuntununtunu kwi-insulin. I-Pterostilbene ivimba ukuguqulwa kweswekile ibe ngamafutha kwaye ithintela iiseli ezinamafutha ukuba zingaphindaphindeki.
I-Pterostilbene inokutshintsha ukwakheka kwezityalo zamathumbu, iikholoni zeentsholongwane ezihlala emathunjini kwaye zincede ukwetyisa ukutya.
Iimpuku ezondla i-pterostilbene zinezityalo ezisempilweni, kubandakanywa ukonyuka okukhulu kwe-Akkermansia muciniphila, uhlobo lwebhaktiriya ebonakala ikhusela ukutyeba, isifo seswekile, kunye nokudumba okukumgangatho ophantsi. I-A. muciniphila isandul' ukugxila kuphando lweprobiotic; izifundo zexesha elizayo ziya kucacisa ukuba kwaye ipterostilbene ikuxhasa njani ukukhula kwayo.
9. Pterostilbene iinzuzo zokukhula kweenwele
Ukutya okunempilo, okunesondlo kungundoqo kwintloko yeenwele eziphilileyo. Ukuzalisa ukutya okutyebileyo kwiiprotheyini kunye neevithamini kuya kunceda ukuphucula inkangeleko yolusu lwakho kwaye uphucule impilo yakho iyonke, kwaye kunjalo, hlala ujonge i-resveratrol okanye iPterostilbene. Ukuba kukulahleka kweenwele ogxile kuko ngoku, unokufuna ukwazisa izongezo kwindlela yakho yesiqhelo. I-Supplement edibanisa iiminerali kunye neevithamini ezondla i-scalp kwaye zinceda ukuxhasa iinwele ezibukeka zisempilweni.
Nazi ezinye izinto onokuzenza ukuze ukhulise wena kunye neenwele zakho:
-Ukuphululwa kwentloko
I-scalp massage elungileyo inokunceda ukukhulula uxinzelelo olujikeleze isithsaba sentloko, kwaye ayivakali nje kakuhle, uphando lubonisa ukuba ukuba uyenza rhoqo, unokufumana inwele ezityebileyo. Kakhulu, ukuba unengxaki ye-alopecia, ukuphululwa kwe-scalp kugxile kwifollicle yeenwele, efumaneka ngezantsi nje komphezulu wolusu. Xa ezi follicles zivuselelwe, imithambo yegazi iyanwenwa kwaye ukukhula kweenwele (okunokwenzeka) kwenzeka.
Phula iinwele zakho izihlandlo ezimbalwa ngeveki kwishawari ukunceda ukonyusa inkangeleko yeenwele zakho kwaye uncede uphumle. Okanye uyisebenzise ukuze usebenze kwiserum yeenwele zakho ozithandayo okanye igwebu ukunceda ukusasaza imveliso kunye noncedo lokufunxa kunye nokuhamba kwegazi.
-Nciphisa Uxinzelelo.
Umhlaba unokuba yindawo enzima, kwaye ngelishwa, ukuba uzifumana uphantsi koxinzelelo olukhulu, unokubona ukulahleka kweenwele ngakumbi kunesiqhelo. (Ngokungathi izinto azikho qhinga ngokwaneleyo!) Ii-stressers ziza kuzo zonke iimilo kunye nobukhulu - mhlawumbi ujongene neemeko ezinzima zokusebenza, okanye mhlawumbi uphila neengxaki zemali. Nokuba yintoni na, ukuba awufumani xesha lokuphumla ngokufanelekileyo, unokufumana iziphumo ebezingalindelekanga zomzimba.
I-telogen effluvium lolona hlobo lokulahleka kweenwele olunxulunyaniswa kakhulu noxinzelelo. Unokufumana kwakhona iAlopecia areata (ukulahleka kweenwele kwiindawo ezithile), iTrichotillomania (ukutsalwa kweenwele) kunye neAndrogenic alopecia (ukuncipha kweenwele). Qinisekisa ukuba utya kakuhle kwaye usebenze kucoceko lwakho lokulala ukukhuthaza imeko yokuhamba kunye nokuphumla okunzulu.
10. Pterostilbene ithamo
Ukongezwa kwe-pterostilbene ngenjongo yokunceda i-glucose kunye ne-lipid metabolism ithande ukuba malunga ne-20- 40mg/kg yokungeniswa ngomlomo kwiimpuku, oluqikelelwa uluhlu lwedosi yomntu:
215-430mg yomntu we-150lb
290-580mg yomntu we-200lb
365-730mg yomntu we-250lb
Iipropathi ezinokwenzeka ze-anxiolytic ze-pterostilbene zibonwa kwi-1-2mg / kg kwiimpuku, okuqikelelwa ukuba idosi yomntu:
5.5-11mg yomntu we-150lb
7.3-14.5mg yomntu we-200lb
9-18mg yomntu we-250lb
Okuphawuleka njenge-5-10mg/kg kwezi mpuku (kancinci ngaphezulu kwedosi ephindwe kabini) ayiphumelelanga ukuba neziphumo ezifanayo ze-anxiolytic, icebisa intsimbi-igophe enokuthi ithande iidosi ezisezantsi ezifumaneka ekutyeni kokutya kunedosi ephezulu ukusuka. ukongeza.
Uphononongo lwabantu olulinganiselweyo lusebenzise nokuba yi-50mg kabini ngemini okanye i-125mg kabini ngemini, kwaye ukongezwa kwembewu yoMdiliya isicatshulwa (i-100mg ngawo omabini amaxesha okudosa) ngedosi ephantsi kunokunciphisa ezinye iziphumo ezibi kwi-cholesterol ebonwa nge-pterostilbene yodwa.
11. Iziphumo ebezingalindelekanga zePterostilbene
Xa kuthelekiswa namayeza amiselweyo ukunyanga iimpawu ezifana ne-cholesterol ephezulu kunye nezinye iingxaki zempilo eziqhelekileyo, i-pterostilbene ayinakwenzeka kakhulu ukuba ibangele iziphumo ezibi (ezifana neentlungu zemisipha kunye nesicaphucaphu). Kukhuselekile ngokubanzi ukutya kokubini kunye nezongezelelo, kodwa kwiidosi eziphezulu kunokuphazamisa iziphumo zamayeza athile.
Ukuba uthatha amayeza ukunceda ukulawula i-cholesterol yakho, uxinzelelo lwegazi kunye / okanye amanqanaba eglucose yegazi, kungcono ukuthetha nogqirha wakho kuqala ngaphambi kokuba uqalise naziphi na izongezo ezintsha. Ugqirha wakho unokukunceda ukujonga indlela osabela ngayo ukuba ukhetha ukuqala ukuthatha i-pterostilbene ukuze uqiniseke ukuba idosi yakho ayifuni kulungiswa.
Nokuba ithathwa ngamaxabiso aphezulu, i-pterostilbene ifunyaniswe ukuba ayinayo ityhefu ngokubanzi. Nangona kunjalo, iidosi eziphezulu azibonakali zibonelela ngezibonelelo ezongezelelweyo, yiyo loo nto kufuneka ulandele iingcebiso zedosi, kwaye ngokophando olupapashwe kwiJenali yeToxicology, "ukubakho kwetyhefu akunakukhutshelwa ngaphandle kwiidosi eziphezulu." Yeka ukuthatha izongezelelo ze-pterostilbene ukuba ufumana isicaphucaphu, iintlungu, ii-hives okanye naziphi na iimpawu ezingaqhelekanga. Ukuba ngaba ulwalisa ukutya kwe-pterostilbene njengamaqunube, amandongomane okanye iidiliya, kufuneka ukuphephe ukutya oku kutya nokuba kuthathwa ngokuba “kusempilweni.”
12. Pterostilbene ixhala
I-Pterostilbene sisicatshulwa esivela kwi-blueberries, ngoko isebenza njenge-anti-oxidant eyomeleleyo. Ilawula okanye inceda ukulungelelanisa imiqondiso yemithambo-luvo kunye nekhemistri kwi-hippocampus, ethi yona ilawule iinkumbulo. I-Pterostilbene inceda ukubuyisela iingcinga kunye neenkumbulo njenge "zingenaxinzelelo," zikwenza uzive ukhululekile. Unokuthatha ezi zongezo zePterostilbene yonke imihla.
13. I-Pterostilbene yokuchuma
Amaqanda omfazi enziwa ngelixa yena ngokwakhe esesiswini. Njengoko loo maqanda ekhula, i-DNA yawo iba buthathaka kwaye ithambekele ngakumbi kumonakalo wechromosomal. Lo monakalo we-chromosomal ngowona nobangela uphambili wokulahleka kokukhulelwa kuwo onke amaqela obudala, kwaye umngcipheko wokuphuphuma kwesisu uyanda njengoko umntu ekhula. Ubudala yeyona nto iphambili echaphazela ukuchuma kowasetyhini.
I-Pterostilbene yi-antioxidant enamandla eye yabonwa inceda kumgangatho weqanda. Kulula kakhulu ukuyithatha kwaye ayizange ibe nengxelo yesigulane naziphi na iziphumo ebezingalindelekanga.
I-Resveratrol yinto echasayo ukuguga, i-antioxidant, i-anti-inflammatory, kunye ne-insulin-sensitizing yendalo yepolyphenolic ikhompawundi. Ubungqina obukhulayo bubonisa ukuba i-resveratrol ineempembelelo zonyango ezinokuthi zibekho kubasetyhini abangafumani bantwana abanomsebenzi ophantsi we-ovarian, i-polycystic ovary syndrome (PCOS), okanye i-endometriosis.
Ngaphandle kokusetyenziswa kwePterostilbene okanye izongezo zeResveratrol, indlela yokuphila elungileyo ilungile nasekuchumeni. Umzekelo:
-ukulala
Okukhona sifunda ngokulala, kokukhona sifumanisa ukuba iiyure ezisibhozo okanye ngaphezulu zifuneka ubusuku ngabunye ukuze ube sempilweni. Oku kuyinyani ngakumbi kumaqanda ethu. Imizimba yethu yenzelwe ukuba ivuke nelanga kwaye ilale xa kumnyama. Ukulala ngokwaneleyo ngundoqo wokulungelelaniswa kwehomoni, ethi yona ixhase ukukhula kweqanda elisempilweni. Ubuthongo bukwadlala indima ebalulekileyo ekugcineni ubunzima obuphezulu, ukukhuthaza amanqanaba afanelekileyo amandla, kunye nokunciphisa uxinzelelo.
-Lolonga
Omnye umthambo ulungile, kodwa kakhulu unokusebenza ngokuchasene nawe xa ufuna ukukhulelwa. Umzimba uneegiya ezimbini:
Ukulwa-okanye-ukubhabha
Ukutya-kunye-nenzala
Umthambo onzima ubeka umzimba kwindlela yokulwa okanye yokubhabha. Oku kuchaphazela amahomoni akho, kucinezela ukukhula kweqanda, kwaye kwenza kube nzima ukukhulelwa. Ukuzilolonga okuthambileyo ukuya kokuphakathi, cinga ukuhamba okanye i-yoga ethambileyo, gcina igazi lakho lijikeleza ngelixa ugcina umzimba wakho ukwimowudi yokutya kunye nokuzala.
14. I-Pterostilbene yezinja
Thelekisa kulwazi malunga nePterostilbene yezinja, ulwazi oluthe kratya malunga neResveratrol yezinja. Uphononongo olwenziwe ngo-2015 lwafumanisa ukuba i-resveratrol yongeza kwaye icinezela amajoni omzimba. I-Resveratrol ikhuthaza iiseli zegazi ezimhlophe ukuba zikhuphe ii-cytokines ezinokuvuvukala ngakumbi kunesiqhelo. Iiseli ezimhlophe zegazi zisebenzisa ezi cytokines ukunxibelelana enye kwenye xa kusilwa usulelo. Okukhona kukho iicytokines, kokukhona womelele amajoni omzimba.
Nangona kunjalo, i-resveratrol ngaxeshanye icinezela amajoni omzimba ngokunciphisa umsebenzi we-neutrophils. Ezi seli zimhlophe zegazi zilwa kwaye zibulale iibhaktheriya ngexesha losulelo. Ezi ziphumo ziphikisanayo zenza kube nzima ngakumbi ukumisela ukuba i-resveratrol iyalunceda ngokwenene na amajoni omzimba.
Ikhompawundi inokuthintela umhlaza, ngakumbi ikholoni kunye nomhlaza wamabele, ngokuthintela kunye nokucothisa ukukhula kweeseli zomhlaza. I-Resveratrol nayo ineempawu ze-antihypertensive, kwaye inokuthintela uxinzelelo lwegazi oluphezulu kunye ne-cholesterol. Kwakhona kucingelwa ukukhuthaza impilo ye-neurological, nangona oku kungaqinisekiswanga. Olunye uphononongo lucebisa ukuba lunokwandisa ubomi besilwanyana.
Ngelixa ezi ziphumo zibonakala zithembisa, oogqirha bezilwanyana basaphanda iziphumo ezipheleleyo ze-resveratrol kwi-immune system. Akukacaci ukuba ukulawulwa kwexesha elide lezongezelelo ze-resveratrol kubangela nayiphi na ingozi kwizinja nakwezinye izilwanyana. Uphando oluthe kratya luyafuneka ukuze kubonwe iziphumo ebezingalindelekanga zekhompawundi, hayi nje ezinjeni kodwa kuzo zonke izilwanyana.
Ukongeza, phantse zonke izifundo ezibonisa ukuba i-resveratrol inenzuzo kakhulu yaqhutywa kwiiseli ezikhuliswe, iimpukane zeziqhamo, intlanzi kunye neempuku. Nangona uphando lubonisa ukuba i-resveratrol yonyusa ubomi bezilwanyana, i-resveratrol iya kuchaphazela izinja ngokwahlukileyo. Kukho izifundo ezimbalwa kwimiphumo ye-resveratrol kwizinja.
Izifundo ezininzi zihlala zinethemba malunga neenzuzo zezempilo ze-resveratrol kuzo zombini ii-canines kunye nabantu. Nangona kunjalo, isenokungabi sisincedisi sommangaliso eminye imithombo ithi injalo.
Uninzi lwezinja ezinempilo aziyi kufuna ukuxhaswa kwe-resveratrol, ngakumbi ekubeni i-resveratrol kufuneka ilawulwe ngamanani amancinci kakhulu. Ukuba ufuna ukongeza i-resveratrol encinci kwisidlo senja yakho, cinga ngokuzondla ama-blueberries okanye amandongomane. Kokubini ukutya kuqulethe i-resveratrol eyenzeka ngokwemvelo, ukongeza kwiivithamini, iiminerali, kunye nentliziyo-enempilo ye-antioxidants.
Ungaze unikeze nayiphi na izongezo kwinja yakho ngaphandle kokuba uyalelwe ngokucacileyo ukuba wenze njalo ngugqirha wezilwanyana. Ukuba uyakholelwa ukuba inja yakho inokuzuza kwisongezelelo se-resveratrol, buza ugqirha wakho wezilwanyana malunga neenzuzo kunye neengxaki ngaphambi kokuba uthenge naziphi na izongezo okanye utshintshe ukutya kwenja yakho. Lawula kuphela izongezo kwiidosi ezicetyiswa ngugqirha wakho wezilwanyana.
15. Kukuphi ukutya okuqulathe iPterostilbene?
I-Pterostilbene ifumaneka kwi-blueberries, kunye nomxholo oqikelelweyo we-blueberry nganye eyahluka phakathi kwe-99 ng ukuya kwi-520 ng, kuxhomekeke kuhlobo lwe-blueberry. Ukubeka oku ngokwembono, i-avareji yepunnet yeblueberry inobunzima obujikeleze i-340 grams.
Ukuba utye i-punnet yonke, isixa esipheleleyo se-pterostilbene obuya kuyifumana kuphela yi-0.03 ukuya kwi-0.18 mg, kwaye ngokusekwe kwidosi esetyenziswa kwizifundo zabantu ezilinganiselweyo ze-100mg ngosuku, iya kuba sisixa esikhulu samaqunube ngosuku!
Nangona kunjalo, ukuba ujonge ukufumana ngokwendalo uhlobo lwamanqanaba e-pterostilbene anikezela ngezongezo zokutya, ke, ngenene, uya kufuna ukuthanda amaqunube, singasathethi ke ngexabiso eliphezulu lokuthenga eso siqhamo. Ngokwenyani, oku akunakwenzeka. Iidosi ezongezelelweyo zivela kwi-50 mg ukuya kwi-1,000 mg nge-capsule nganye.
I-Pterostilbene ikwafumaneka kwiialmondi, amagqabi omdiliya kunye nemidiliya, iicranberries kunye namaqunube eVaccinium anxulumeneyo, anje nge-lingonberries, iibilberries, kunye namaqunube.
16. Yintoni i Pterostilbene ithathwe kwi?
I-Pterostilbene (i-trans-3,5-dimethoxy-4-hydroxystilbene) i-stilbene compound eyakhiwe ngokufana nezinye i-stilbenes ezithandwayo ezifana ne-resveratrol okanye i-piceatannol; ithiywe ngemvelaphi yayo yokuqala efunyenweyo (i-pterocarpus genus) kodwa ikwayinxalenye yamaqunube kunye neemveliso zediliya. Yi phytoalexin (icompound eveliswa zizityalo njengokhuselo kwiiparasites kunye nezinambuzane) efana ne-resveratrol nangona inamandla ngakumbi.
Imithombo yePterostilbene ibandakanya:
| I-Pterocarpus marsupium (i-Indian Kino Tree) kunye ne-pterocarpus santalinus (i-Sandalwood) |
| Amaqunube (92-550ng/g ubunzima bomileyo) |
| Amagqabi omdiliya (Vitis vinifera) kunye namaqunube |
| Anogeissus acuminata |
| Uhlobo lweDracaena |
| I-Rheum rhaponticum (ingcambu) |
| Amandongomane (Arachis hypogaea) |
17. Pterostilbene imithombo yendalo
I-Pterostilbene ifumaneka kwiialmonds, amaqunube ahlukeneyo eVaccinium (kubandakanya amaqunube aluhlaza), amagqabi omdiliya kunye nemidiliya, kunye nePterocarpus marsupium heartwood.
18. Ngaba iPterostilbene yiphytoestrogen
Usapho lwe-stilbenes lwe-phytoestrogens lubandakanya i-reseveratrol kunye ne-pterostilbene edla ngokufumaneka kwiwayini ebomvu kunye namandongomane.
19. Ngaba iPterostilbene ngamafutha anyibilika
Ewe, lo ngomnye umahluko phakathi kwePterostilbene kunye neResveratrol kwakhona.Ngaphandle kwamaqela e-methoxy i-Resveratrol ayikho njenge-lipophilic (i-oyile-enyibilikayo) njenge-pterostilbene, ngoko ke ukuthathwa kweselula kungaphantsi kakhulu kune-pterostilbene - i-pterostilbene inokuthatyathwa nge-lipid yeseli. -Umaleko ngokulula ngokulula.
20. Ngaba iPterostilbene yamanzi iyanyibilika?
IPterostilbene ayinyibiliki ngokwenyani (emanzini) kunye nekhompawundi eneasidi ebuthathaka kakhulu (esekwe kwipKa yayo). I-Pterostilbene inokufumaneka kumdiliya oqhelekileyo kunye newayini yediliya, eyenza ukuba i-pterostilbene ibe yi-biomarker enokubakho ekusetyenzisweni kwezi mveliso zokutya.
21. Ngaba iPterostilbene iyayonyusa iLDL?
Ewe, iPterostilbene yonyusa i-LDL xa isetyenziswa kwi-monotherapy. I-Pterostilbene inciphisa uxinzelelo lwegazi kubantu abadala kwi-250 mg / ngosuku. Kubonakala ngathi kukho amandla okunciphisa ubunzima kumaqela amancinci athile nge-pterostilbene.
22. Ngaba Pterostilbene uxinzelelo lwegazi oluphantsi?
Uhlobo lwe-pterostilbene, i-compound efunyenwe ngokwemvelo kwi-blueberries, iyanciphisa uxinzelelo lwegazi kubantu abadala, ngokweziphumo zovavanyo lwekliniki olunikezelwe ngoSeptemba 20 kwi-American Heart Association's 2012 Scientific Sessions on High Blood Pressure Research eWashington, DC.
I-randomized, i-double-blind-blind, i-placebo-controlled controlled study yenziwa yi-University of Mississippi School of Pharmacy kunye nabaphandi beSikolo seMedicine ukuba i-pterostilbene (tero-STILL-bean), iphucula impilo ye-cardiovascular.
Abaphandi bavavanya isithako kwizigulane ze-80 ezine-cholesterol ephezulu (i-cholesterol epheleleyo ye-200 okanye enkulu kunye / okanye i-LDL ye-cholesterol ye-100 okanye ngaphezulu). Kabini yonke imihla kangangeeveki ezintandathu ukuya kwezisibhozo, abathathi-nxaxheba bafumana nokuba kuphezulu (125 mg) iidosi zepterostilbene, ezisezantsi (50 mg) iidosi zepterostilbene, pterostilbene (50 mg) enesicatshulwa somdiliya (100 mg), okanye indawo ye-placebo, utshilo uDaniel M. URiche, umphandi oyintloko wolu phando. Abaphandi bavavanya uxinzelelo lwegazi lwezigulane, ubunzima bomzimba kunye negazi lipids ekuqaleni nasekupheleni kokuthatha inxaxheba kwabo kwisifundo.
"Sifumene uxinzelelo lwegazi oluncitshisiweyo lwe-systolic kunye ne-diastolic kwizigulana ezifumene idosi ephezulu ye-pterostilbene kunye nokunciphisa uxinzelelo lwegazi lwe-systolic kwizigulana ezifumene idosi ephantsi ye-pterostilbene ngesicatshulwa somdiliya," utshilo uRiche, unjingalwazi oncedisayo kwi-pharmacy practice kunye neyeza. UM iziko lezonyango eJackson.
Abathathi-nxaxheba kwiqela eliphezulu le-pterostilbene (i-250 mg ngosuku) bazuze ukunciphisa okukhulu kwixinzelelo lwegazi xa kuthelekiswa ne-placebo: i-7.8 mmHg kwi-systolic BP (p ngaphantsi kwe-0.01) kunye ne-7.3 mmHg kwi-diastolic BP (p ngaphantsi kwe-0.001).
23. Ngaba iPterostilbene iyingozi
I-Pterostilbene ithathwa njengekhuselekile kwaye ayinazo iziphumo ebezingalindelekanga zibalulekileyo ukuya kuthi ga kwidosi ye-250 mg ngosuku. Abanye abantu basenokuba baye banyusa i-cholesterol ye-LDL xa bethatha i-pterostilbene; Isicatshulwa sembewu yomdiliya siyasigatya esi siphumo kwaye sinokudibana kakuhle nesongezo septerostilbene.
Okwangoku akukho zifundo malunga nokhuseleko lwe-pterostilbene kubantwana okanye kwabasetyhini abakhulelweyo okanye abancancisayo. Ngenxa yokuba le khompawundi iqhele ukufunyanwa ekutyeni kwaye ithathwa njengesempilweni, iidosi ezincinci zepterostilbene kufuneka zikhuseleke nakubani na; nangona kunjalo, isilumkiso siyacetyiswa kwiidosi eziphezulu.
Thetha nogqirha wakho ngaphambi kokuba unike i-pterostilbene kubantwana okanye uzithathele ngokwakho ukuba ukhulelwe okanye uncancisa.
24. Ingakanani iPterostilbene ekufuneka ndiyithathe?
IPterostilbene ikhuselekile ngokubanzi ukuba isetyenziswe ebantwini kwiidosi ukuya kuthi ga kwi-250 mg ngosuku. I-Pterostilbene inyamezeleke kakuhle kwi-dosing kabini yonke imihla
25. Pterostilbene ngokutya okanye ngaphandle?
Ngokophononongo olokuqala oluyilwe kakuhle uthelekiso lwe-pterostilbene kulingo lwabantu olulawulwayo olunoluhlu lwedosi. Kubonakala ngathi akukho siphumo esithe ngqo se-pterostilbene kumanyathelo e-hepatic okanye umsebenzi wezintso.
Akukho unxulumano olungalindelekanga lwe-pterostilbene kunye ne-ADR yesisu (kunye okanye ngaphandle kokutya) okanye ukurhawuzelelwa njengoko zombini ii-ADR ezixeliweyo zenzeke kumlinganiselo ophantsi kuphela kwi-placebo nakumaqela ethamo eliphezulu.
26. Ngaba kufuneka uthathe iPterostilbene?
Ulingo lomntu lubonise ukuba i-pterostilbene ikhuselekile ukuya kuthi ga kwi-dose ye-250 mg ngosuku. Yiphose kumxube into yokuba iqhele ukufumaneka ekutyeni, kwaye kuyacaca ukuba i-pterostilbene ikhuselekile ngokubanzi ukuba ingasetyenziswa. Gcina ukhumbula, nangona kunjalo, ukuba eli chiza liphakamisa inqanaba le-cholesterol 'embi' kubasebenzisi.
27. Leliphi elona xesha losuku lokuthatha iPterostilbene?
Abantu banokubuza "Ndingathatha nini i-resveratrol, i-pterostilbene, i-curcumin kunye ne-quercetin ngesiphumo esifanelekileyo? ”
Kukhethwa ukuba isetyenziswe ekuseni, okanye ngokuhlwa, kodwa hayi emini. Yidla ngamanzi, kunye nesidlo esincinci (isidlo sakusasa).
28. Zeziphi izongezo eziqulathe Pterostilbene?
Njengoko abantu benikela ingqalelo ngakumbi nangakumbi kwimpilo, imfuno yabantu yezongezo iyanda imihla ngemihla. Izongezelelo zePterostilbene yenye yazo, ethandwa kakhulu ngabantu.
Esona sithako siphambili sePterostilbene isongezelelo ngokuqinisekileyo ngumgubo wePterostilbene, unokusetyenziselwa ukwenza iintlobo ezahlukeneyo, kubandakanya icapsule, iipilisi, isiselo…
I-Pterostilbene njengemolekyuli ye-methylated stilbene, inesakhiwo esifanayo ne-antioxidant resveratrol. I-Pterostilbene kunye ne-resveratrol zabelana ngezibonelelo ezininzi ezifanayo, kubandakanya ukulwa noxinzelelo lwe-oxidative, kodwa i-pterostilbene ibonakaliswe ukuba inokufumaneka okuphezulu kwe-bioavailability. Ngamanye amazwi, i-pterostilbene kukholelwa ukuba ifunxwe kwaye isetyenziswe ngumzimba ngokulula ngakumbi kune-phytonutrients efanayo, sesinye sezizathu zokuba isanda kubamba ingqalelo yabaphandi bezempilo.
29. Ngaba iPterostilbene ingcono kuneResveratrol?
1). Yintoni iResveratrol
Resveratrol yinxalenye yeqela leekhompawundi ezibizwa ngokuba ziipolyphenols. Bacingelwa ukuba basebenze njenge-antioxidants, ukukhusela umzimba kumonakalo onokukubeka emngciphekweni ophezulu kwizinto ezifana nomhlaza kunye nesifo senhliziyo. I-Resveratrol ixhasa impilo ye-cardiovascular, ukukhusela i-antioxidant, i-glucose metabolism, ibhalansi ephilileyo yokuvuvukala, kunye nokunye. I-Pterostilbene ngoku itshatshelelwe njengeyona ndlela inamandla ne-bioavailability ephezulu.
I-Resveratrol powder (501-36-0) ulwazi olusisiseko
| igama | I-Resveratrol powder |
| CAS inani | 501-36-0 |
| Ukungcola | 98% |
| Igama leKhemikhali | Resveratrol |
| Iintetho ezifanayo | 5 - [(1E) -2- (4-Hydroxyphenyl) ethenyl] -1,3-benzenediol; iTrans-Resveratrol; (E) -5- (p-Hydroxystyryl) i-resorcinol; (E) -Ukuhlaziywa kwakhona; Ukuhamba-3,4 ', 5-Trihydroxystilbene; |
| I-Molecular Formula | C14H12O3 |
| Isisindo somzimba | 228.24 g / mol |
| Indawo yokunyibilika | 243-253 ° C |
| InChI Key | I-LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| imo | Powder |
| Ubomi obulicla | kwizifundo, cebisa ubomi behafu ukuya kuthi ga kwiiyure eziyi-1.6 |
| yoGcino Imeko | khusela ukukhanya, 2-8 ° C |
| isicelo | Ubuncinci be-wayini ye wayini, edibene nokuncitshiswa kwe-serum lipid kunye nokuthintela ukuhlanganiswa kweplatelet. I-Resveratrol sisithinteli esithile se-COX-1, kwaye ikwathintela nomsebenzi we-hydroperoxidase ye-COX-1. Kuboniswe ukuthintela iziganeko ezinxulumene nokuqaliswa kwe-tumor, ukukhuthaza kunye nokuqhubela phambili. |
| Umfanekiso wepakethi |  |
| COA,HPLC | iyafumaneka |
2). Pterostilbene vs Resveratrol
-Ukuthelekiswa kwe-Bioavailability kunye neeNzuzo zeMpilo
Phantse kumashumi amabini eminyaka eyadlulayo, kwafunyaniswa ukuba i-resveratrol yanciphisa inkqubo yokuguga kwamaselula kwigwele. Kwi-2003, iNjingalwazi yeSikolo sezoNyango saseHarvard uDavid Sinclair, PhD, wafumanisa ukuba i-resveratrol isebenze i-gene yokuphila ixesha elide ebizwa ngokuba yi-SIRT1 kunye neklasi yesiphumo se-sirtuin proteins.
Emva koko, indlela efanayo yaphononongwa kwaye yafunyanwa iyinyani kwiimpuku. Uphando kwi-resveratrol emva koko lwajikela kwiziphumo zalo kwimpilo yabantu. I-Resveratrol yafunyanwa ukuxhasa impilo ye-cardiovascular, ukukhusela i-antioxidant, i-glucose metabolism, ibhalansi ephilileyo yokuvuvukala, kunye nokunye. Njengoko iziphumo zolu phando zixeliwe, abantu baba nomdla ngakumbi ekuseleni iwayini ebomvu ene-resveratrol kunye nokuthatha izongezo ze-resveratrol.
Nangona kunjalo, eminye yemiqobo emikhulu yokuvuna izibonelelo ze-resveratrol ebantwini ibonakala ngathi yi-bioavailability elinganiselweyo kunye nokupheliswa ngokukhawuleza emzimbeni. Kodwa loo miqobo inokoyiswa yinkomponi esele iphawuleka mva nje.
Malunga neminyaka eyi-10 emva kokufunyaniswa ukuba i-resveratrol yenza i-gene yokuphila ixesha elide, abaphandi baqala ukuthatha umdla kumzala wakhe we-molecular, pterostilbene. Nangona ikhoyo kwindawo ephezulu yeeblueberries kunewayini ebomvu, i-pterostilbene iphantse yafana kulwakhiwo lweekhemikhali kwi-resveratrol.
Uphononongo lokuqala lokhuseleko lomntu lwe-pterostilbene lwapapashwa ngo-2013, kwaye uphando luye lwaqina ukusukela ngoko. I-Pterostilbene ngoku itshatshelelwe njengeyona ndlela inamandla ye-resveratrol. Kuthiwa ibonelela ngazo zonke izibonelelo ezaziwa ngaphambili ze-resveratrol kodwa nge-bioavailability ephezulu. Ngaba la mabango ayinyaniso? Funda kuthelekiso oluneenkcukacha zezi khompawundi zomzala zimbini.
-Umahluko kuLwakhiwo
I-Resveratrol kunye ne-pterostilbene zombini zizityalo ezivele ngokwendalo. I-Resveratrol igxile kwiintsuba zediliya kunye newayini ebomvu, kodwa iye yabekwa yodwa kwiingcambu ze-knotweed yaseJapan. I-Pterostilbene igxile ikakhulu kumaqunube, kodwa ifunyenwe ngamanqam amancinci, iidiliya kunye nekoko.
I-Resveratrol kunye ne-pterostilbene ziwela kwiklasi yeekhompawundi ezibizwa ngokuba yi-stilbenes. Ezi khompawundi phenolic ziquka amakhonkco amabini anevumba elimnandi kunye namaqela hydroxyl (-OH). I-Resveratrol kunye ne-pterostilbene zifana kakhulu kwisakhiwo, kodwa ngomzuzu omnye-kodwa ubalulekile-umahluko. I-Resveratrol inamaqela amathathu e-hydroxyl, ngelixa i-pterostilbene inenye kuphela. Amanye amaqela amabini e-hydroxyl atshintshwa ngamaqela e-methoxy (O-CH3) kwi-pterostilbene.
Umahluko kwinani lamaqela e-hydroxyl ubalulekile kuba uphembelela ukuba i-compound ikhawuleza kangakanani i-metabolized kwaye ikhutshwe emzimbeni. Amaqela amathathu e-hydroxyl kwi-resveratrol akhawulezisa ukususwa kwe-molecule, eyenza kube nzima ukufikelela kunye nokugcina amanqanaba axabisekileyo e-resveratrol egazini.
Ngeqela elinye kuphela le-hydroxyl kwi-molecule nganye, i-pterostilbene iyakwazi ukuqhubeka nokujikeleza ixesha elide. Umahluko omncinci kulwakhiwo wenza ukuba i-pterostilbene ibe ne-lipophilic ngakumbi. I-Pterostilbene inokudlula ngokulula kwiinwebu zeseli-iyenza ifumaneke ngakumbi ukuxhasa iindlela zeselula.
Zombini i-resveratrol kunye ne-pterostilbene ngokwendalo zenzeka ngeendlela ezimbini: i-cis kunye ne-trans. Ii-transforms zizinzile kwaye zininzi ngokwendalo. Uphononongo lucebisa ukuba kuzo zombini i-resveratrol kunye ne-pterostilbene, ii-transforms ziphezulu kwiifom ze-cis ngokwemigaqo yebhayoloji.
-Bioavailability kunye neHalf-life
Iindaba ezimnandi malunga ne-resveratrol kunye ne-pterostilbene zezokuba zombini zifunxwa ngokulula emva kokuthatha ngomlomo, kwaye ziyakwazi nokuwela umqobo wegazi-buchopho. Iindaba ezimbi zezokuba zenziwa i-metabolism ngokukhawuleza. Ixesha labo lokujikeleza lifutshane.
Izinga lokufunxa i-resveratrol ukusuka kwi-lumen yamathumbu malunga neepesenti ze-75, kodwa i-metabolism yayo ekhawulezayo kwisibindi iphumela kwi-bioavailability yomlomo kuphela malunga neepesenti ze-1. Kungenxa yokuba isibindi sivelisa i-resveratrol conjugates-ikakhulukazi i-glucuronides kunye ne-sulfates. Kuphononongo lwe-bioavailability yabantu, amavolontiya anempilo e-15 ngamnye athatha i-capsule ye-500 mg ye-trans-resveratrol. Iisampulu zegazi ezithathwe emva kwe-dosing zibonise ukuba i-resveratrol yamahhala imele kuphela i-0.28 yepesenti ye-resveratrol epheleleyo ekujikelezeni, kunye nezinye ziquka i-conjugated glucuronides okanye i-sulfates.
Uphononongo lukwabonise ukuba i-resveratrol yayihlala ixesha elifutshane-ukugxininiswa kwayo kwanda malunga neyure enye emva kokuthatha. Eso siphumo sasifana nophononongo lwangaphambili, olwafumanisa ukuba isiqingatha sobomi be-trans-resveratrol sasiyiyure enye ukuya kweyesithathu emva kwedosi enye.
Xa ikhompawundi ine-bioavailability ephantsi kangaka kunye nesiqingatha sobomi obufutshane, kunzima ukugcina ugxininiso kumjikelezo. Olunye uphononongo lwafumanisa ukuba nangona abantu bathatha i-150 mg ye-trans-resveratrol amaxesha amathandathu ngosuku, basenayo i-plasma concentrations ephantsi.
Olunye uthelekiso olukhankanyiweyo lwe-resveratrol kunye ne-pterostilbene kukuba i-bioavailability yomlomo ye-resveratrol yipesenti ezingama-20 kuphela, ngelixa i-pterostilbene ifikelela kwi-80 ekhulwini. Kodwa kubalulekile ukuqaphela ukuba ezi pesenti zibhekisa kwitotali edityanisiweyo ye-resveratrol kunye ne-resveratrol sulfate, kunye ne-pterostilbene kunye ne-pterostilbene sulfate. Kubaluleke ngakumbi ukuqaphela ukuba ezi pesenti zivela kuphononongo olwaqhutywa kwiimpuku kunokuba lube ngabantu.
Olunye uthelekiso olusoloko lukhankanywa kukuba isiqingatha sobomi be-pterostilbene siphindwe kasixhenxe kunolo lwe-resveratrol. Le statistical ivela kwizifundo ezimbini: Omnye uxele ukuba i-resveratrol inesiqingatha sobomi bemizuzu eyi-14, kwaye enye yaxela ukuba i-pterostilbene inesiqingatha sobomi bemizuzu eyi-105. Kwakhona, olu yayiluphononongo lwangaphambili olwaqhutywa hayi ebantwini kodwa kwimivundla, iimpuku, kunye neempuku.
Kushiyeke imibuzo emininzi engaphendulwanga. Asazi ukuba i-metabolites edibeneyo ye-resveratrol kunye ne-pterostilbene inomsebenzi we-biological kwinqanaba le-tissue (kukho ubungqina bomsebenzi, nangona ngaphantsi kwe-resveratrol yamahhala). Kwakhona, akwaziwa ukuba idatha ye-bioavailability kwi-pterostilbene evela kwizifundo zezilwanyana inokuguqulelwa ebantwini.
Abaphandi abaninzi kunye noogqirha bathatha idatha encinci esinayo ukuza kuthi ga ngoku malunga nokubakho kwe-pterostilbene kunye nokusebenza nayo. Ngokusekwe kuphononongo olukhankanywe ngasentla, i-pterostilbene ifumene udumo lokuba yeyona ndlela inamandla kunye ne-bioavailable ye-resveratrol.
-Ukuthelekiswa kweeNzuzo zeMpilo
I-Resveratrol iphandiwe ngokubanzi. Izifundo zovavanyo zibonisa ukuba i-resveratrol imodareyitha iindlela ezininzi zeemolekyuli kwinqanaba leselula. Isebenzisana, umzekelo, kunye neendlela zeselula ezinxulumene nebhalansi yokuvuvukala okunempilo, i-apoptosis, kunye ne-autophagy. Ikwasebenzisana neendlela ezinxulumene nokuguga kunye nokuphila ixesha elide, njenge-telomeres kunye ne-cell senescence.
Ngaphandle kwe-bioavailability ephantsi, kukho ubungqina obuninzi bokukwazi kwe-resveratrol ukukhuthaza impilo ebantwini. Izilingo ezihleliweyo, ezilawulwayo zibonise ukuba i-resveratrol supplementation isekela ukulawulwa kobunzima obunempilo, i-metabolism yeswekile yegazi, i-cardiovascular function, i-mood, ibhalansi ephilileyo yokuvuvukala kunye noxinzelelo lwe-oxidative. Izibonelelo zempilo zeResveratrol nazo zibonakalisiwe kwezinye izifundo ezininzi, kunye nohlalutyo lwemeta.
Xa kuziwa kwi-pterostilbene, ubungqina buninzi kakhulu. Ngaphandle kophononongo lokhuseleko olupapashwe ngo-2013, kubekho amalingo ambalwa kakhulu aqhutywe ebantwini. Kwakukho uphononongo olunye, olwenziwa kwiYunivesithi yaseMississippi kubantu abadala abangama-80, olwafumanisa ukuba i-pterostilbene ixhasa uxinzelelo lwegazi olusempilweni kunye ne-lipid metabolism.
Uninzi lophando kwi-pterostilbene lukwinqanaba lovavanyo kunye nenqanaba lokuqala. Abaphandi baye bafumanisa ukuba i-pterostilbene ixhasa iindlela ezininzi zeselula ezifana ne-resveratrol-kubandakanya ukuxhasa ukhuseleko lwe-antioxidant kunye neendlela zokulungelelanisa ezibandakanyekayo kwi-balance inflammatory balance, apoptosis, kunye ne-autophagy. Uninzi lweengcali ziyavuma ukuba iindlela zemolekyuli zepterostilbene kufuneka zithathelwe ingqalelo zilingana nezo ze-resveratrol.
30. Ngubani ongafanele athathe i-resveratrol
Izigulane ezinokuphazamiseka kwegazi, ezinokubangela ukopha, kufuneka zijongwe ngugqirha ngelixa uthatha le mveliso. Abantu abatyandwayo kufuneka bayeke ukuthatha i-resveratrol kwiiveki ezimbini ngaphambi kotyando kwaye bangayithathi iiveki ezimbini emva kotyando ukunciphisa umngcipheko wokuphuma kwegazi.
Musa ukuthatha izongezo ze-resveratrol okanye izixa ezigqithisileyo zokutya zendalo ezine-resveratrol ngelixa ukhulelwe okanye uncancisa. Kukho ukunqongophala kophando kule ndawo ukubonisa ukhuseleko. I-Resveratrol kufuneka iphetshwe ebantwaneni.
I-Resveratrol inomsebenzi omncinci we-estrogenic kwaye kude kube ngaphezulu kwaziwe, abasetyhini abanomhlaza kunye nezinye iimeko ezinobuthathaka be-estrogen kufuneka bafune iingcebiso zonyango ngaphambi kokuthatha i-resveratrol.
I-Resveratrol inciphisa umsebenzi we-enzymes echaphazelekayo kwi-metabolism yeziyobisi kodwa ingaba inefuthe elibalulekileyo ebantwini ayizange ifundwe.
31. Ingakanani i-resveratrol ekhuselekileyo?
Izongezelelo ze-Resveratrol zikhuselekile xa zithathwa ngomlomo kwiidosi ukuya kuthi ga kwi-1500 mg yonke imihla ukuya kwiinyanga ezi-3. Amanani aphezulu ukuya kwi-2000-3000 mg imihla ngemihla asetyenziswe ngokukhuselekileyo kwiinyanga ze-2-6. Kodwa la mayeza aphezulu kunokwenzeka ukuba abangele ukuphazamiseka kwesisu.
32. Pterostilbene kunye caffeine
I-caffeine yi-methylxanthine efumaneka kwiimbotyi zekofu, kwiimbotyi zekoko kunye nakwiti. Uphando lubonisa ukuba i-caffeine yinto evuselela ingqondo eyandisa ukuphaphama, ukuphaphama, ukuqaphela, imemori yokusebenza, kunye nomsebenzi wemoto.
Kukho imveliso eyikhompawundi enelungelo elilodwa lomenzi ebophelela i-caffeine kunye ne-pterostilbene enamandla ye-antioxidant. Ukubophelela ikofu kunye ne-pterostilbene kunciphisa kakhulu izinga lokufunxa kwe-caffeine eyandisa isiqingatha sobomi bayo kunye nokuhambisa ukuya kuthi ga kwi-30% yesiphumo esipheleleyo ngelixa kuncitshiswa iimpawu eziqhelekileyo ze-caffeine.
33. I-Pterostilbene ene-quercetin
1) Yintoni i-quercetin kunye neenzuzo zayo
I-Quercetin yi-pigment yesityalo (i-flavonoid). Ifumaneka kwizityalo ezininzi nasekutyeni, njengewayini ebomvu, itswele, iti eluhlaza, iiapile namaqunube.
I-Quercetin ine-antioxidant kunye ne-anti-inflammatory effects enokunceda ukunciphisa ukudumba, ukubulala iiseli zomhlaza, ukulawula iswekile yegazi, kunye nokunceda ukukhusela isifo senhliziyo.
I-Quercetin isetyenziswa kakhulu kwiimeko zentliziyo kunye nemithambo yegazi kunye nokuthintela umhlaza. Ikwasetyenziselwa isifo samathambo, usulelo lwesinyi, kunye nesifo seswekile, kodwa abukho ubungqina obuqinileyo bezenzululwazi bokuxhasa uninzi lolu setyenziso. Akukho bungqina bulungileyo bokuxhasa ukusebenzisa i-quercetin kwi-COVID-19.
2) Pterostilbene vs Quercetin
Kukho iklasi ekhethekileyo ye-antioxidant compounds ebizwa ngokuba yi-flavonoids okanye i-polyphenols, ngoko ke ukutya ukutya okutyebileyo kwiziqhamo kwaye ngakumbi imifuno kunokuhamba indlela ende ekugcineni usempilweni.
I-Quercetin kunye ne-pterostilbene zimbini ezifana ne-flavonoids. Nangona kunjalo, ngenxa yokuba ezi antioxidants zifumaneka kwimilinganiselo emincinci kuphela ekutyeni okumbalwa kwaye amandla omzimba wakho wokufunxa kwimo yawo yendalo imbi okanye ayanelanga, amandla akho okufumana inzuzo alinganiselwe.
Nge-Quercetin kunye ne-Pterostilbene ifomula ephucukileyo, sebenzisa ubuchwephesha bokufundisa ukunyusa ukufumaneka kwe-bioavailability ye-compounds kangangezihlandlo ezingama-20. Ngefomula ekhethekileyo, unokufumana:
I-1) Ixhasa ukhuseleko lwakho lwendalo kwizisongelo zonyaka.
2) Ixhasa impilo yemiphunga kunye ne-bronchial tract.
3) Ixhasa ukuveliswa kwe-mitochondria entsha kwingqondo yakho kunye nemisipha.
I-4) Ixhasa impendulo ephilileyo, eqhelekileyo yomzimba.
I-5) Inceda ukukhusela iiseli kunye nezicubu kumonakalo omkhulu wamahhala.
6) Ixhasa impendulo esele iqhelekile yokuvuvukala.
I-7) Yongeza ukusebenza kwengqondo emva koxinzelelo olukhulu lomzimba.
8) Ixhasa ukuguga kwamaselula okunempilo.
9) Inceda ukukhusela kwi-lipid peroxidation kwiiseli zakho kunye nezicubu.
10) Ixhasa impilo ye-metabolic.
34. Pterostilbene vs berberine
I-Berberine yikhompawundi ye-bioactive enokuthi itsalwe kwizityalo ezininzi ezahlukeneyo, kuquka neqela lezihlahla ezibizwa ngokuba yiBerberis. I-HCL yifom ye-hydrochloride ye-Berberine, inombolo ye-CAS yi-633-65-8.
Ngokobuchwephesha, yeyodidi lweekhompawundi ezibizwa ngokuba ziialkaloids. Inombala otyheli, kwaye ihlala isetyenziswa njengedayi.
IBerberine inembali ende yokusetyenziswa kumayeza emveli aseTshayina, apho yayisetyenziselwa ukunyanga izifo ezahlukeneyo.
Ngoku, isayensi yanamhlanje iqinisekisile ukuba inezibonelelo ezintle kwiimfuno ezahlukeneyo zempilo.
I-Pterostilbene yinto efumaneka kubungakanani obuncinci kumaqunube. Ngobungakanani obukhulu, inokuphucula ukuvakalelwa kwe-insulin (R, R, R), kwaye inokuphucula uhlobo lwe-2 yeswekile (R, R).
Kanye njenge-metformin, i-pterostilbene inokuphinda isebenze i-AMPK (R). Enyanisweni, i-pterostilbene isebenze i-AMPK esele ikwinqanaba le-50 micromolar, ngelixa i-metformin iphumelele umphumo kwi-dose ephezulu ye-2 millimolar (R).
35. I-Pterostilbene kunye ne-NMN
1) Yintoni i-NMN
I-NMN imele i-nicotinamide mononucleotide, imolekyuli eyenzeka ngokwemvelo kuzo zonke iintlobo zobomi. Kwinqanaba le-molecular, yi-ribo-nucleotide, eyona yunithi yesiseko ye-nucleic acid RNA. Ngokwesakhiwo, i-molecule yenziwe liqela le-nicotinamide, i-ribose kunye neqela le-phosphate. I-NMN isandulela esithe ngqo semolekyuli eyimfuneko i-nicotinamide adenine dinucleotide (NAD+) kwaye ithathwa njengenxalenye ephambili yokunyusa amanqanaba e-NAD+ kwiiseli.
I-NMN powder (1094-61-7) ulwazi olusisiseko
| igama | Umgubo we-NMN |
| CAS inani | 1094-61-7 |
| Ukungcola | 99% |
| Igama leKhemikhali | I-beta-Nicotinamide mononucleotide |
| Iintetho ezifanayo | I-3-Carbamoyl-1- [5-O- (hydroxyphosphinato) -β-D-ribofuranosyl] pyridinium |
| I-Molecular Formula | C11H15N2O8P |
| Isisindo somzimba | 334.221 g / mol |
| Indawo yokunyibilika | > 96 ° C |
| InChI Key | I-DAYLJWODMCOQEW-TURQNECASA-N |
| imo | Powder |
| Ubomi obulicla | / |
| yoGcino Imeko | I-Hygroscopic, -20˚C Ifreezer, phantsi kwe-Inert atmosphere |
| isicelo | I-Nicotinamide mononucleotide ("NMN", "NAMN", kunye ne "β-NMN") yi-nucleotide ethathwe kwi-ribose kunye ne-nicotinamide. |
| COA,HPLC | iyafumaneka |
| Umgubo we-NMN |  |
2) I-Pterostilbene ene-NMN
Ukudibanisa i-pterostilbene kunye ne-NMN (i-nicotinamide mononucleotide) ingaba yi-duo enamandla yokunciphisa inkqubo yokuguga. I-NMN yisandulela se-NAD+, i-coenzyme ebalulekileyo efunekayo kuyo yonke iseli emzimbeni. Ukuncipha kumanqanaba e-NAD + kukhokelela ekonyukeni kwenkqubela phambili yokuguga kunye nesifo.
Zombini i-pterostilbene kunye ne-NMN zi-activators ze-sirtuins, intsapho yeeprotheni ezilawula impilo yeselula kunye ne-mitochondrial kunye nokulawula inkqubo yokuguga. Ukonyuka komsebenzi we-sirtuin, ngakumbi i-SIRT1, inxulunyaniswe nokwandiswa kwexesha lokuphila kwigwele kunye nezilwanyana. Ngenxa yobukho bayo obuphezulu be-bioavailability, i-pterostilbene inokuba yinto eyomeleleyo ye-sirtuin activator kune-resveratrol.
Ukudibanisa i-pterostilbene kunye ne-NMN kunokonyusa ukusebenza kwe-NMN kuba ii-activators ze-sirtuin kunye nee-boosters ze-NAD+ zisebenza kunye. Njengoko i-pterostilbene inyusa umsebenzi we-sirtuin, ukongeza i-NMN ivumela i-molecule yangaphambili ukuba yenze umsebenzi wayo ophambili wokunyusa amanqanaba e-NAD+.
Ngokusisiseko, i-NMN kunye ne-pterostilbene zisebenza ngokubambisana ukuphucula impilo ye-mitochondrial kunye nokucothisa inkqubo yokuguga, njengoko i-NMN inyusa amanqanaba e-NAD+ kwaye zombini iikhompawundi zisebenzisa ii-sirtuins.
36. I-Pterostilbene kunye ne-Nicotinamide riboside
1) Yintoni Nicotinamide riboside(NR)
Nicotinamide riboside lilungu losapho lwevithamin B3, ekwaquka iniacin kunye neniacinamide. Ifumaneka kwiziqhamo, imifuno, inyama, nobisi.
INicotinamide riboside iyatshintshwa emzimbeni ibe yikhemikhali ebizwa ngokuba yiNAD+. Umzimba udinga i-NAD + ukuze iinkqubo ezininzi zisebenze ngokuqhelekileyo. Amanqanaba aphantsi anokubangela iingxaki zempilo. Ukuthatha i-nicotinamide riboside kunokunceda ukunyusa amanqanaba aphantsi e-NAD+.
Abantu basebenzisa i-nicotinamide riboside kwiziphumo zokulwa nokuguga, i-cholesterol ephezulu, uxinzelelo lwegazi oluphezulu, isifo se-Alzheimer, ukutyeba, kunye nezinye iinjongo ezininzi, kodwa abukho ubungqina obulungileyo besayensi bokuxhasa oku kusetyenziswa.
Sukubhida i-nicotinamide riboside kunye ne-niacin, i-niacinamide, okanye i-NADH. Ezi zonke ziyazalana kodwa azifani.
2) Pterostilbene nge Nicotinamide riboside(NR)
Ezinye izongezo zokutya zinePterostilbene kunye neNicotinamide Riboside(NR). INicotinamide riboside isandulela senicotinamide adenine dinucleotide(NAD+). Ukuba uthatha iPterostilbene ngeNicotinamide Riboside “NR” (Uphononongo), unokufuna ukuphinda uqwalasele. Ingcali ye-NR uDkt Charles Brenner wachaza kwi-Twitter ngaphambili.
37. Ukuthenga phi Pterostilbene?
I-Wisepowder njengomvelisi othe ngqo, unikezela ngeyona nto ingcono kakhulu ye-Pterostilbene powder ukusuka kwigram-KG-Ton ukuxhasa iimfuno zabathengi abahlukeneyo.
