iimveliso

I-Olivetol powder (500-66-3)

IOlivetol yinto evele ngokwendalo. Ifumaneka kwiindidi ezithile zeelayisen kwaye inokukhutshwa ngokulula. I-5-Pentylresorcinol ikwaveliswa linani lezinambuzane, nokuba zi-pheromone, repellent okanye antiseptic. Isityalo se-cannabis ngaphakathi sivelisa i-olivetolic acid (i-OLA) ehambelana noko, neyayicingelwa ukuba isityalo sisebenzisa ukuguqula imeko yemveliso yengqondo ye-tetrahydrocannabinol (THC).

Ukuvelisa: Imveliso yeBatch
ipakethe1KG / ibhegi, 25KG / igubu
Umgubo wobulumko unamandla okuvelisa nokubonelela ngobuninzi. Yonke imveliso phantsi kwemeko ye-cGMP kunye nenkqubo engqongqo yokulawula umgangatho, onke amaxwebhu okuvavanya kunye nesampuli ekhoyo.

I-Olivetol powder (500-66-3) ividiyo

 

 

I-Olivetol powder (500-66-3) Ulwazi olusisiseko

igama I-Olivetol (3,5-hydroxypentylbenzene) ipowder
CAS 500-66-3
Ukungcola 98%
Igama leKhemikhali IOlivetol
Iintetho ezifanayo I-3,5-Dihydroxyamylbenzene; I-5-n-Amylresorcinol; I-5-n-Pentylresorcinol; I-1,3-Dihydroxy-5-pentylbenzene; I-5-Pentyl-1,3-benzenediol;
I-Molecular Formula C11H16O2
Isisindo somzimba 180.2435
Indawo yokunyibilika 46-48 ° C (i-lit.).
InChI Key I-IRMPFYJSHJGOPE-UHFFFAOYSA-N
imo ziqinile
Kubonakala umbala omfusa ukukhanya kwekristalu emdaka
Ubomi obulicla /
Umzimba I-soluble emanzini (ngokuyinxalenye engachazwanga), chloroform, kunye ne-methanol.
yoGcino Imeko Kwigumbi lokugcina elomileyo nelingeneyo; kude nelanga; uphephe umlilo; uphephe ukufuma.
isicelo I-Olivetol i-biosynthesized yi-polyketide-synthase-uhlobo reaction evela kwi-hexanoyl-CoA kunye nee-molecule ezintathu ze-malonyl-CoA yi-aldol condensation ye-tetraketide intermediate.
UXwebhu loVavanyo iyafumaneka

 

I-Olivetol powder (500-66-3) Inkcazo ngokubanzi

I-Olivetol yayisetyenziswa njengemolekyuli yetemplate kwindlela yokuqulunqwa kwepolymer (MIP). Isetyenziswe njenge-inhibitor ye (S) -mephenytoin 4'-hydroxylase yomsebenzi weCYP2C19 ephindaphindiweyo.

I-Olivetol isetyenziswa ngeendlela ezahlukeneyo ukuvelisa ii-analog zokwenziwa ze-THC.full cation efunekayo] Enye indlela enjalo kukuphendula kwe-olivetol kunye ne-pulegone. EPiHKAL, uAlexander Shulgin uxela indlela ecekeceke yokuvelisa imveliso efanayo ngokuzisa i-olivetol yokusabela kunye neoyile eyimfuneko yeorenji apho kukho iphosphoryl chloride.

Indlela yokwakheka kwe-THC ngokwayo iqulathe indlela yokuphendula phakathi kwe-olivetol kunye ne-Δ2-carene oxide

 

I-Olivetol powder (500-66-3) Imbali

I-Olivetol i-biosynthesised yi-polyketide synthase-type reaction evela kwi-hexanoyl-CoA kunye neemolekyuli ezintathu ze-malonyl-CoA yi-aldol condensation ye-tetraketide ephakathi. Ngo-2009, uTaura et al. ikwazile ukwenza uhlobo lwe-PKS yohlobo lwe-olivetol synthase (OLS) evela kwi-Cannabis sativa. Le PKS yiprotein ye-homodimeric equlathe i-385 amino acid polypeptide enobunzima beemolekyuli ezingama-42,585 Da ezinokulandelelana okuphezulu (60-70%) isazisi sokutyala ii-PKS's.

 

Isicelo se-Olivetol powder (500-66-3) Isicelo

1, Isetyenziswe njengeshishini lamayeza.

I-2, Isetyenziswe njengePhakathi yeOrganic.

I-3, isetyenziswe njengokumiselwa kwe-lipopolysaccharides, i-carrageenan kunye ne-sialic acid.

 

I-Olivetol powder (500-66-3) Olunye uphando

Ukuvelisa, ukubangaba, kunye / okanye ukuhambisa ioli yomnquma akukho mthethweni kulo naliphi na ilizwe; nangona kunjalo, e-United States, yi-DEA ejonge phambili.

 

I-Olivetol powder (500-66-3) Reference

  • Kumano, T., et al: Bioorg. IMed. Imichiza, 16, 8117 (2008), Appendino, G., et al .: J. Nat. Imveliso., 71, 1427 (2008), Sampietro, D., et al: Ukutya Chem., 115, 1170 (2009),
  • . Jiang R, et al. I-Cannabidiol sisithinteli esinamandla semisebenzi yokuvuselela ye-cytochrome P450 2C19. Iziyobisi Metab Pharmacokinet. Ngo-2013; 28 (4): 332-8.
  • . Yamaori S, et al. I-Cannabidiol, i-phytocannabinoid ephambili, njenge-inhibitor enamandla ye-atypical ye-CYP2D6. Iidiski zeMachiza yeziyobisi. Ngo-2011 i-Nov; 39 (11): 2049-56.

 

Amanqaku aKhanyayo