iimveliso

I-Alpha-lipoic Acid powder (1077-28-7)

I-Alpha-lipoic acid / thioctic acid powder yichemical efana ne-vitamin ebizwa ngokuba yi antioxidant Igwele, isibindi, izintso, isipinatshi, ibroccoli, kunye neetapile yimithombo elungileyo yealpha-lipoic acid / thioctic acid. Ikwenziwe elebhu ukuba isetyenziswe njengeyeza. I-alpha-lipoic acid / thioctic acid ixhaphakileyo ithathwa ngumlomo wesifo seswekile kunye neempawu ezinxulumene nemithambo-luvo yesifo seswekile kubandakanya ukutsha, iintlungu, kunye nokuqaqamba emilenzeni nasezingalweni. Inikwa kwakhona njengenaliti emthanjeni (nge-IV) kwezi zinto zisetyenziswayo. Imithamo ephezulu ye-alpha-lipoic acid / thioctic acid yamkelwe eJamani kunyango lweempawu ezinxulumene nemithambo-luvo.

Ukuvelisa: Imveliso yeBatch
ipakethe1KG / ibhegi, 25KG / igubu
Umgubo wobulumko unamandla okuvelisa nokubonelela ngobuninzi. Yonke imveliso phantsi kwemeko ye-cGMP kunye nenkqubo engqongqo yokulawula umgangatho, onke amaxwebhu okuvavanya kunye nesampuli ekhoyo.

I-alpha-lipoic Acid powder Base Ulwazi

 

igama I-alpha-lipoic Acid powder
CAS 1077-28-7
Ukungcola 98%
Igama leKhemikhali (+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-valeric Acid; (+/-) -Alpha-lipoic Acid / Thioctic acid; (RS) -cy-Lipoic Acid
Iintetho ezifanayo I-DL-Alpha-lipoic Acid / iThioctic acid; ILiposan; Lipothion; NSC 628502; NSC 90788; IProtogen A; IThioctan;
I-Molecular Formula C8H14O2S2
Isisindo somzimba 206.318 g / mol
Indawo yokunyibilika Ngowe-60-62 ° C
InChI Key I-AGBQKNBQESQNJD-UHFFFAOYSA-N
imo solid
Kubonakala Ukukhanya okuLuhlaza kokuHheli
Ubomi obulicla Imizuzu engama-30 ukuya kwiyure enye
Umzimba I-soluble kwiChloroform (ngokuthe ngcembe), i-DMSO (ngokuthe nkcwe), Methanol (ngokuthe nkcwe)
yoGcino Imeko Okomileyo, omnyama kunye no-0 ukuya ku-4 C okwexesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).
isicelo Isikhuseli se-fat-metabolism.
UXwebhu loVavanyo iyafumaneka
IAlfa-lipoic Acid
Umfanekiso womgubo
Uluphuzi Ophuzi

 

Yintoni ialpha-lipoic acid?

I-alpha-lipoic acid yi-antioxidant ephuma kwi-caprylic acid. Amanye amagama ayo yi-ALA, i-lipoic acid, iBiletan, iLipoicin, iThioctan, njl.njl. Yindibaniselwano ye-organosulfur kwaye iveliswa emzimbeni wabantu nakwizilwanyana. Imveliso yayo ivela kwi-octanoic acid kunye necysteine ​​njengomthombo wesalfure. Yinto ebalulekileyo kwimetabolism ye-aerobic emzimbeni. Ikho kwiseli nganye kwaye inceda ukudala amandla kwi-glucose.

Inemisebenzi emininzi yeselula kunye neemolekyuli, ngenxa yamandla ayo okulwa ne-antioxidant. Isenzo sokulwa ne-alpha-lipoic acid sikhulise umdla waso wokusebenzisa njengesongezo sesondlo. Isetyenziswa njengesixhobo sonyango. Inokuba lunyango olunokwenzeka kwisifo seswekile, ukwehla kobunzima, i-neuropathy ebangelwe sisifo seswekile, ukuphilisa amanxeba, ukuphucula imeko zolusu, njl.

I-alpha-lipoic acid powder inesiqingatha sobomi semizuzu engama-30 ukuya kwiyure enye. Iyanyibilika kancinci kwi-chloroform, i-dimethyl sulfoxide (i-DMSO), kunye ne-methanol. Inokufumaneka kwisipinatshi, igwele, ibroccoli, iitapile, inyama efana nesibindi kunye nezintso.

Elona dosi liphezulu linokuthathwa ngumntu omdala ngemini ngama-2400mg.

 

Isebenza njani iAlpha-lipoic Acid?

I-alpha-lipoic acid ineempawu zokulwa ne-antioxidant. Kuthetha ukuba inokulwa ngokubonakalayo ngokuchasene neeradicals simahla emzimbeni kwaye icothise izehlo ezinje ngokuguga kweseli kunye nokunceda ukugcina iiseli ezisempilweni.

Iveliswa kwi-mitochondria kwaye isebenza njenge-cofactor ebalulekileyo yokuphula i-enzymes kunye nezondlo. Ikwahlaziya ii-ion zentsimbi kunye nokunciphisa ifom ye-oxidized yezinye i-antioxidants ezinje nge-vitamin C, i-Vitamin E, kunye ne-glutathione. IAlpha-lipoic acid iyimfuneko ekulawuleni iintlobo zeoksijini ezisebenzayo.

IAlfa-lipoic acid ikwakhuthaza inkqubo yokhuseleko ye-antioxidant. Yenza oku ngokusebenzisa i-Nrf-2-mediated antioxidant expression expression. Ikwahlengahlengisa imfuza efuna iproxisome proliferator ukuze isebenze.

I-alfa-lipoic acid ikwathintela inyukliya kappa B. Ivula iprotein kinase (AMPK) esebenzayo ye-AMP kwimisipha yamathambo kwaye ibangela iintshukumo ezahlukeneyo zemetabolic.

Zimbini iindlela ze-alpha-lipoic acid. Zidibene ne-lipoic acid (LA) kunye ne-dihydrolipoic acid (DHLA). I-DHLA iveliswa kwimitochondria equkethe iiseli emzimbeni. Oku kunokwenzeka nge-nicotinamide adenine dinucleotide hydrogen (NADH) kunye ne-lipoamide dehydrogenase. Ezi zinto zimbini zinceda kule ndlela yokuguqula.

Kwiiseli ezingenayo i-mitochondria, i-alpha-lipoic acid inokuncitshiswa ibe yi-DHLA ngokusebenzisa i-nicotinamide adenine dinucleotide phosphate (NADPH). Eli nyathelo lincediswa yi-glutathione kunye ne-thioredoxin ukunciphisa.

IAlfa-lipoic acid inepropathi eyahlukileyo eyenza ukuba yahluke kwi-glutathione. Ngelixa kuphela uhlobo olwehlisiweyo lwe-glutathione yi-antioxidant, zombini iindlela ezincitshisiweyo kunye nezingancitshiswanga ze-alpha-lipoic acid zinamandla e-antioxidants.

I-alpha-lipoic acid ikwabandakanyeka ekulungiseni iiproteni ze-oxidized kwaye inokunceda kulawulo lokukhutshelwa kwemfuza.

I-Alpha-lipoic acid ineepropathi ezichasayo. Iyeka i-kappa B kinase, i-enzyme eyenza ukuba i-NF-kB isebenze, into eguqula ii-cytokines ezivuthayo [1].

 

Imbali yeAlpha-lipoic Acid

I-alpha-lipoic acid yafunyanwa ngo-1937 ngu-Snell. Ngelo xesha, oosonzululwazi babefunda uhlobo lweebhaktiriya ezazisebenzisa incindi yeetapile xa zivelisa. Ngomnyaka we-1, yahlukaniswa nguReed. Ukusetyenziswa kokuqala kweklinikhi kwaqala eJamani ngo-1951 ukunyanga ityhefu ngenxa yamakhowa okusweleka.

Ulwazi malunga nokusetyenziswa kwe-alpha-lipoic acid kunye nokusebenza kwayo alukagqitywa. Ukusetyenziswa kwayo kunyango akuqinisekiswanga yi-FDA okwangoku. Kodwa kule minyaka idlulileyo, ifumene ukuthandwa njengesongezelelo.

 

Zithini iziphumo ebezingalindelekanga zealpha-lipoic acid?

Njengoninzi lwamayeza, i-alpha-lipoic acid nayo ineziphumo ebezingalindelekanga.

Ezinye zeempembelelo eziqhelekileyo ze-alpha-lipoic acid zi:

  • intloko ebuhlungu
  • Ukuguquka
  • I sizathu
  • Ukuvutha
  • Hypersensitivity
  • Intloko yokukhanya
  • Ishukela eliphantsi kwegazi
  • Ukugqithisa isikhumba
  • Ukufakwa ngaphakathi

Iziphumo ze-alfa-lipoic acid yomgubo koomama abakhulelweyo nabancancisayo awaziwa. Kuyacetyiswa ukuba uphephe ukusebenzisa oku xa ukhulelwe okanye uncancisa.

 

Zeziphi izibonelelo zeAlpha-lipoic Acid?

Kukho izibonelelo ezininzi ze-alpha-lipoic acid. Bazi:

 

Iziphumo kwizifo ze-Alzheimer's

I-alpha-lipoic acid powder inokubangela ukulibazisa ukuqala okanye ukunciphisa ukuhamba kwesifo se-neurodegenerative. Kwenziwa isifundo kwizigulana ezisithoba ezinesifo i-Alzheimer's. I-600mg ye-Alpha-lipoic acid yanikwa yonke imihla iinyanga ezili-12 [2]. Kwakunakho ukuzinzisa ukuqonda kwezi zigulana. Ipropathi yayo ye-antioxidant inokucothisa imeko kwaye inokuthi isebenze njengearhente yokhuselo.

 

Iziphumo kwiSwekile

I-alpha-lipoic acid inokunceda ukunciphisa amanqanaba eswekile yegazi kwizigulana ezinesifo seswekile. Kuba iipropathi zayo zokulwa ne-antioxidant zinokuphelisa ii-radicals simahla emzimbeni, inokunceda ukunyanga umonakalo kwiiseli ezibangelwa sisifo seswekile. Inokuphucula ukunganyangeki kwe-insulin kubantu abanesifo seswekile. Inokuthintela ukusweleka kweeseli ze-beta kwaye isenokuphucula ukuthathwa kweglucose kwaye icothise iingxaki zesifo seswekile, ngakumbi isifo seswekile isifo sengqondo [3].

 

Iziphumo kwiStroke

I-alpha-lipoic acid inezakhono ze-neuroprotective. Izenzo zayo zokulwa ne-antioxidant zinokunceda ekwandeni kwe-neuron kwingqondo ethe yafumana ukubetha. Uphononongo olwenziwe kwiigundane ezine-ischemic stroke ezanikwa i-alpha-lipoic acid yabonisa ukuphucuka kwimeko yazo [4]. Yiyo loo nto inokunceda ukuphucula imeko yezigulana ezibethwa sistroke.

 

Iziphumo zokuguga

I-alpha-lipoic acid powder nayo inokunceda ekunciphiseni ukuguga kwesikhumba. I-alfa-lipoic acid inokubonelela nge-elektron enye kulusu olonakalisayo nolugulayo olubangela isithako esisebenzayo kunye nokuzidibanisa. Ngale ndlela inokuyeka ukuguga kwaye inokugcwalisa indima yecandelo le-antioxidant elinesiphene [5]. Oku kunokunceda ngokuchasene nomonakalo obangelwe zizinto ezahlukeneyo.

 

Iziphumo kwiTyhefu yeMercury kunye neAutism

I-alpha-lipoic acid ingadlulisa isithintelo segazi-lobuchopho. Isenokusetyenziselwa ukukhupha i-mercury eqhotyoshelwe kwiiseli zobuchopho kwimeko yetyhefu ye-mercury [6]. Inokuhlanganisa i-mercury ebotshiweyo egazini ukusuka apho ezinye ii-chelator ezinje nge-dimercaptosuccinic acid (DMSA) okanye i-methylsulfonylmethane (MSM) inokuhambisa i-mercury ngokukhuselekileyo kwizintso kwaye ikhutshelwe ngaphandle kumchamo. Njengoko i-DMSA okanye i-MSM ingakwazi ukuwela isithintelo segazi-ngengqondo, ukusebenzisa i-alpha-lipoic acid kunye ne-DMSA kunokunceda ekususeni ngokukhuselekileyo i-mercury. Oku kunokunceda ekunyangeni i-autism njengabantwana be-autistic banamanqanaba aphezulu e-mercury kwiingqondo zabo xa kuthelekiswa nesiqhelo. Nangona kunjalo, izifundo ngokubhekisele koku zikhawulelwe.

 

Iziphumo kwiAnemia

Kwaqhutywa isifundo kwizigulana ezinesifo sezintso esine-anemia apho i-alpha-lipoic acid yanikwa abaguli [7]. Ibonakalise ukuba inamandla njenge-erythropoietin ekonyuseni amanqanaba e-hemoglobin ngaphandle kweziphumo eziyingozi. Yiyo loo nto inokunceda ukunyanga i-anemia ebangelwa kukungaphumeleli kwinqanaba le-renal. Inokuba luncedo kwezoqoqosho.

 

Iziphumo njenge-Antioxidant

Kuba i-alpha-lipoic acid powder iyi-antioxidant, inezibonelelo ezininzi kwaye inokunceda kwiintlobo ezininzi zeemeko emzimbeni.

 

Iziphumo kwi-Neurotoxicity ngenxa yoTywala

Utywala bunokubangela ukuphazamiseka kwemithambo-luvo ngenxa yoxinzelelo lwe-oxidative. I-Alpha-lipoic acid inokunceda ekunyangeni i-neurotoxicity ngenxa yotywala. Inokuthintela i-protein oxidation eyenzeka kwi-ethanol intake [8].

 

Iziphumo ekulahlekeni kobunzima

I-alpha-lipoic acid inokuba sisongezo esifanelekileyo ekuncedeni ukunciphisa umzimba kubantu abatyebe kakhulu kwaye batyebe kakhulu [9]. Ineziphumo ebezingalindelekanga ezingaphantsi xa kuthelekiswa namanye amayeza okunciphisa umzimba kwaye inee-antioxidants ezinokunceda ekugcineni umntu esempilweni.

 

Ukungqinelana

Akukho zifundo zininzi ngokuchasene ne-alpha-lipoic acid. Nangona kunjalo, abanye abaguli abaneemeko ezithile kufuneka balumke ngaphambi kokusebenzisa le nto kwaye babonane nogqirha ngaphambi kokuba bayisebenzise.

Ezinye zeemeko zezi:

  • Isifo sesibindi
  • Ukusetyenziswa ngokweqile kotywala
  • Isifo se-thyroid
  • Ukuswela ityamine

 

Ukudibana kweziyobisi neAlpha-lipoic Acid

Akukho lwazi lungako malunga nokusebenzisana kwe-alpha-lipoic acid kunye nezinye iziyobisi. Kodwa amanye amayeza angcono ukuba aphetshwe ngolu ncediso.

Amanye ala machiza ngala:

Iziyobisi ze-Hypoglycemic -Alfa-lipoic ineswekile yegazi yokunciphisa amandla. Ngamanye amaxesha kunokubangela i-insulin autoimmune syndrome, ekhokelela kwi-hypoglycemia. Ke ukuyisebenzisa ngamachiza e-hypoglycemic kunokubangela i-hypoglycemia ekhawulezayo enokuba yingozi.

Amayeza e-thyroid -Alpha-lipoic acid inokuhlisa amanqanaba ehomoni ye-thyroid. Ukubeka iliso ngokufanelekileyo kuyafuneka xa kusetyenziswa i-levothyroxine.

 

Ungayithenga phi iAlpha-lipoic Acid ngo-2021?

Ungathenga i-alpha-lipoic acid powder ngokuthe ngqo kwinkampani yomenzi wealpha-lipoic acid. Itholakala ngokukhanya okuqinileyo okuluhlaza ukuya kumgubo omthubi. Ipakishwe kwiphakheji ye-1 kg ngepakethi nganye kunye ne-25kg kwigubu ngalinye. Nangona kunjalo, oku kungatshintshwa ngokweemfuno zomthengi.

Ifuna ukugcinwa kubushushu obungu-0 ukuya ku-4 ° C kwixesha elifutshane kunye -20 ° C ixesha elide. Ifuna indawo ebandayo, emnyama, neyomileyo yokugcina ukuze kuthintelwe ukuba iphendulwe ngamanye amachiza kwindalo esingqongileyo. Le mveliso yenziwe ngezona zinto zilungileyo zilandela iiprotocol ezifanelekileyo.

 

Izalathiso zikhankanyiwe

  1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). IAlfa-lipoic acid ineziphumo ezichasayo ezichasayo kwi-lipopolysaccharide-evuselelekileyo iiseli ze-mesangial nge-inhibition yenyukliya factor kappa B (NF-κB). Ukuvutha, 38(2), 510-519.
  2. IHager, K., Kenklies, M., McAfoose, J., Engel, J., kunye neMünch, G. (2007). I-α-lipoic acid njengonyango olutsha lwesifo se-Alzheimer-Uhlalutyo olulandelayo lweenyanga ezingama-48. Kwi Ukuphazamiseka kwi-Neuropsychiatric Indlela yokuDibanisa(iphepha 189-193). Isipringi, eVienna.
  3. U-Laher, mna (2011). Iswekile kunye ne-alpha-lipoic acid. Imida kwi-pharmacology, 2, 69.
  4. Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Unyango lwe-alpha-lipoic acid luyi-neurorestorative kwaye lukhuthaza ukubuyiswa kokusebenza emva kokubethwa ziigundane. Ingqondo yemolekyuli, 8(1), 1-16.
  5. UKim, K., uKim, uJ., UKim, uH, no-Sung, uGY (2021). Iziphumo ze-α-Lipoic Acid kuPhuhliso lweZikhumba zoLuntu eziLingana zisebenzisa iModeli yePump-Skin-on-a-Chip. I-International Journal ye-Molecular Sciences, 22(4), 2160.
  6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Ukuqonda kwi-alpha-lipoic kunye ne-dihydrolipoic acids njengezithembiso ezithembisayo zoxinzelelo lwe-oxidative kunye ne-chelators ezinokubakho kwi-mercury toxicology. Ijenali ye-biochemistry engaphiliyo, 195, 111-119.
  7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Indima ye-alpha-lipoic acid kulawulo lwe-anemia kwizigulana ezinesifo esinganyangekiyo sezintso eziphantsi kwe-hemodialysis. Ijenali yamanye amazwe ye-nephrology kunye nesifo sokuhlaziya, 6, 161.
  8. UPirlich, M., Kiok, K., uSandig, uG., ULochs, uH, noGrune, uT. (2002). I-Alpha-lipoic acid ithintela i-ethanol-indased protein oxidation kwimouse ye-hippocampal ye-HT22 yeeseli. Iincwadi zeeuroscience, 328(2), 93-96.
  9. I-Kucukgoncu, S., Zhou, E., Lucas, KB, kunye neTek, C. (2017). I-Alpha-lipoic acid (ALA) njengesongezelelo sokunciphisa umzimba: iziphumo ezivela kuhlalutyo lwe-meta-lwezilingo ezilawulwa ngokungahleliwe. UPhononongo lokuTyeba kakhulu, 18(5), 594-601.

 

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