I-Oleoylethanolamide (i-OEA): Isiyobisi esilahlekelwe sisisindo esinceda ukuba kulawulwe ukutya.

Yintoni iOleoylethanolamide (OEA)?

Uleoylethanolamide (OEA) sisilawuli sendalo sobunzima, i-cholesterol kunye nokutya. Imetabolite yenziwe ngamanani amancinci kumathumbu amancinci. Imolekyuli yendalo inoxanduva lokuziva ugcwele emva kokuba uthathe ukutya. I-Oleoylethanolamide incedisa kulawulo lwamafutha omzimba ngokuzibophelela kwi-Peroxisome proliferator-activated receptor alpha (PPAR-Alpha). Le metabolite yendalo iphucula ukutyeba komzimba kunye nokwazisa ingqondo yakho ukuba uthathe ukutya okwaneleyo kwaye kufuneka uyeke ukutya. I-Oleoylethanolamide ikwonyusa inkcitho yeekhalori ezinxulumene nokungasebenzi.

Usebenza njani u-Oleoylethanolamide (OEA)?

I-Oleoylethanolamide (OEA) Mechanism yesenzo

I-Oleoylethanolamide (OEAimisebenzi njenge isilawuli somdla. I-Oleoylethanolamide ilawula ukutya kwakho xa kuthumela imiqondiso kwingqondo ikwazisa ukuba ugcwele, kwaye lixesha lokuba uyeke ukutya. Ngenxa yoko, uthatha ukutya okuncinci yonke imihla, kwaye umzimba wakho uyema ukupakisha ubunzima obungakumbi kwixesha elide.

I-Oleoylethanolamide (OEA) (111-58-0) Uveliswa kwaye uhanjiselwe amathumbu amancinci asuka kwi-oleic acid evela kukutya. Ukutya okunamafutha aphezulu kunokunqanda ukuveliswa kwe-Oleoylethanolamide kwithumbu elincinci.

I-Oleoylethanolamide isezantsi ukutya okufunxa ngokuvuselela ukujikeleza kwengqondo ye-histamine, i-oxytocin ye-homeostatic, kunye neendlela ze-hedonic dopamine. Kuyabonakala ukuba i-Oleoylethanolamide inokuthi ikwazi ukufaka umqondiso we-CB1R, onokuthi ukuba ukhuthaziwe ungakhokelela ekutyeni kokutya. I-Oleoylethanolamide iyanciphisa ukuthuthwa kwe-lipid kwii-adipocytes zokuthoba ubunzima bamanqatha.

I-OEA ikwasebenza ukukhuthaza into eyaziwa ngokuba yi-PPAR kwaye kwangaxeshanye kunciphisa ukugcinwa kwamafutha kunye nokunyusa ukutshiswa kwamafutha. Nanini na xa usitya, amanqanaba e-OEA akhuphuka kwaye inkanuko yakho iwe phantsi. Oku kuyenzeka kuba iimvakalelo zengqondo ezihambelana nengqondo yakho zazisa ukuba ubulela ngokupheleleyo kwi-PPAR-α. I-PPAR-α yinto eyamkela i-ligand-activated receptor ebandakanyeka kumandla endlela yokuhambisa ekhaya kunye nokubonisa uhlobo lwe-lipid metabolism.

I-Oleoylethanolamide (OEA) ibonisa zonke iimpawu ezichaza isatiety factor ezibandakanya:

• Ukuthintela ukondla ngokwandisa ixesha lokuphumla phakathi kwesidlo esinye kwisidlo esilandelayo;
• Ukuveliswa kwayo kulawulwa ngokufumaneka kwezakha mzimba
• Amanqanaba ayo ahamba ngokuguquguquka kwesekethe.

IziBonelelo ze-Oleoylethanolamide (OEA)

Izibonelelo ze-Oleoylethanolamide kunye neziphumo zokunciphisa umzimba zibandakanya;

i. Ukunciphisa inkanuko evuselelayo yehomoni eyaziwa ngokuba yiGhrelin

Inaliti etyhutyha-tyhutyha ye-OEA enikwa iintonga ebezila ukutya imini enye azange ibe nefuthe kwi-hormone ye-ghrelin ngaphakathi kwemizuzu eli-120, kodwa emva kweeyure ezi-6 kwabakho ukwehla okumangalisayo kule hormone ngama-40 ukuya kuma-50 epesenti. Nangona kunjalo, i-Oleoylethanolamide yayingenaziphumo kukugxininiswa kolu lonwabo lwenkanuko ekhuthaza iihomoni kwizitya ezondisiweyo. Oku kucebisa ukuba isongezelelo se-OEA sisebenza kakuhle ukunciphisa amanqanaba e-ghrelin ukuba athathwe ngaphambi kokutya.

ii. Ukunyusa izinga lokulahleka kwamafutha omzimba

Ii-receptor ze-βeta-adrenergic receptors zisebenza ukukhuthaza ukunciphisa umzimba kunye nokukhuthaza i-βeta3-adrenergic receptor ikhuthaza ukwehla kokutya kunye nokunyuka kwamafutha kumadlala. I-receptor yenza oko ngokunyusa iiprotheni ezingafakwanga kubandakanya i-UCP1.

Ngenxa yoko, ukulawulwa ngokudibeneyo kwe-ag3 agonist kunye ne-oleoylethanolamide yenaliti yenaliti kubonakala ngathi kuyasebenza ekunciphiseni ukutya okutya kunye nokusebenza ngokufanelekileyo ekunciphiseni ubunzima bamafutha obunxulunyaniswa nokunyuka kwenkcitho yamandla. Ukunyuka kwamanqanaba e-UCP1 kunye ne-PPARcy (ekucingelwa ukubonisa ukunyuka kwenkcitho yamandla) kwenzeka kuzo zombini izicwili ezimdaka nezimhlophe ze-adipose ecaleni kwezincedisi ze-mitochondrial biomarkers.

I-OEA ke ibonakala iphucula iziphumo ze-mitochondrial metabolism kunye ne-thermogenic vitendo kwiringi kuzo zombini izicwili ezinombala omdaka kunye nomhlophe, kwithamo ye-oleoylethanolamide efanayo njengoko isetyenziselwa ukulawula umdla.

iii. Ukuthoba amaNqanaba e-Peptide YY (Ukuphakama-kwehomoni yeHome)

Inaliti ye-5mg / kg ye-Oleoylethanolamide kwiirandi zibangele ukwehla okuxhomekeke kwi-hormone peptide YY eveliswa emathunjini kwimeko yokutya kunye nokutya.

Ngaba i-Oleoylethanolamide (i-OEA) inceda uLawulo lweAtyala?

Ewe. I-Oleoylethanolamide isongezelelo sokunciphisa umzimba sinceda ukuba lawula ukutya ngokwenza i-PPAR isebenze ngaloo ndlela kunciphisa ukugcinwa kwamafutha kunye nokunyusa ukutshiswa kwamafutha. Xa uthatha izidlo zakho, amanqanaba e-Oleoylethanolamide ayakhuphuka kwaye iphango lakho lokutya lincinci xa kuthunyelwa imiqondiso kwingqondo yakho ikwazisa ngengqondo ukuba wanelisekile.

Kukho izifundo zenzululwazi ezininzi ezingqina oku. Ngo-2004, umzekelo, abaphandi baseDenmark bafunda iimpuku ezazingafakwanga ukutya ngosuku olunye. Babanike i-OEA kwaye baqonda ukuba isixa sokutya abasithathileyo sehle nge-15.5%. Ngamagama alula, i-Oleoylethanolamide (OEA) icima isitshisi sendlala kwi-CNS (i-Central Nervous System).

I-Oleoylethanolamide (OEA) Umthamo

Isithamo sedosi ye-oleoylethanolamide yecephe enye eyi-200mg xa ithathwe ngaphandle kwendibaniselwano. Xa zidityaniswa nezinye izongezo zokunciphisa umzimba, idosi ye-OEA kufuneka yehliswe ibe phakathi kwe-100mg kunye ne-150mg.

Kucetyiswa ukuba uthathe i-oleoylethanolamide ukongeza kwimizuzu engama-30 ngaphambi kwesidlo sangokuhlwa okanye isidlo sakusasa; Uya kuziva waneliseke ngakumbi ngexesha lakho lokutya kwaye ugqibile ukuthatha ukutya okuncinci.

Uphando lubonisa ukuba unokuthoba okanye unyuse imithamo yemihla ngemihla ngokwamanqanaba omzimba. Umzekelo, ukuba une-150lb, unokuthatha i-100mg. Umntu we-200lb unokuthatha i-150mg kwaye umntu we-250lb unokuthatha i-180mg yesongezelelo.

I-Oleoylethanolamide (OEA) Iziphumo zeSide

Iziphumo ezibi ze-Oleoylethanolamide inokuba yinkxalabo enkulu phakathi kwabavelisi abongezayo abafuna ukubandakanya esi sithako sinamandla kwifomula yabo yokulahleka kwesisindo.

Emva koqwalaselo olunzulu lwayo yonke idatha yesayensi ekhoyo, i-FDA yase-US (uLawulo lokuTya nokuTya iziyobisi) ayinangxaki malunga nokhuseleko lwale molekyuli yendalo. I-RiduZone yayingumgubo wokuqala we-OEA ukuphawulwa ngo-2015.

I-OEA yi-oleic acid metabolite kunye nenxalenye yesidlo semihla ngemihla. Kukhuseleke ngokupheleleyo ukuthatha isongezelelo se-Oleoylethanolamide kuba akukho ziphumo zibi zichaziweyo ukuza kuthi ga ngoku.

I-Oleoylethanolamide (OEA) Thenga

Ungafumana i-oleoylethanolamide yokuthenga kwiivenkile ezininzi ezikwi-Intanethi nakwiziyobisi. Kuya kufuneka kodwa ulumke kuba ayingabo bonke abathengisi abanyanisekile. Qiniseka ukuba ufunda uphononongo lwabo lwe-oleoylethanolamide ukuze wazi ukuba ayintoni amava abathengi babo bangaphambili.

Ngaba uyazibuza ukuba ungayifumana phi i-oleoylethanolamide? Sukuba nexhala; ungathenga i-oleoylethanolamide online apha kwiwebhusayithi yethu. Siphindaphindekile kwaye sinamava OEA Umthengisi kwaye sinakho ukuhambisa iOleoylethanolamide (OEA) e-USA nakwamanye amazwe aliqela kwihlabathi liphela. Inkqubo yethu yoku-odola ilula kodwa ikhuselekile ngokupheleleyo kwaye ikhuselekile. Sikwanikezela ngeemveliso zethu kwiipakethe ezitywinwe ngokuqinileyo kunye ezintle ukuqinisekisa ukhuseleko kunye nokuthintela nakuphi na ukungcoliseka.

Isiqendu ngo:

UGqirha Liang

Umququzeleli, ubunkokheli bobunkokheli kwinkampani; I-PhD ifunyenwe kwiYunivesithi yaseFudan kwi-organic chemistry. Ngaphezulu kweminyaka esithoba yamava kwicandelo lokudibanisa izinto eziphilayo. Amava atyebileyo kwi-chemistry yokudibanisa, amayeza ekhemesti kunye nokwenziwa kwesiko kunye nolawulo lweprojekthi.

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